Exploring the heterogeneous transcriptional response of the CNS to systemic LPS and Poly(I:C)

Breaking down the cellular responses to type I interferon neurotoxicity in the brain

(2023) Barney Viengkhou et al.   Frontiers in Immunology

Antithymocyte Globulin Inhibits CD8+ T Cell Effector Functions via the Paracrine Induction of PDL-1 on Monocytes

(2023) Dragan Copic et al.   Cells

Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood–brain barrier

(2023) Phetcharawan Lye et al.   Fluids and Barriers of the CNS

IFNAR signaling of neuroectodermal cells is essential for the survival of C57BL/6 mice infected with Theiler’s murine encephalomyelitis virus

(2023) Melanie Bühler et al.   Journal of Neuroinflammation

Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease

(2023) Monika Piwecka et al.   Nature Reviews Neurology

Type I interferon shapes brain distribution and tropism of tick-borne flavivirus

(2023) Nunya Chotiwan et al.   Nature Communications

Comparison of methods and resources for cell-cell communication inference from single-cell RNA-Seq data

(2022) Daniel Dimitrov et al.   Nature Communications

The astroglial and stem cell functions of adult rat folliculostellate cells

(2022) Patrick A. Fletcher et al.   GLIA

Brainstem ADCYAP1+ neurons control multiple aspects of sickness behaviour

(2022) Anoj Ilanges et al.   NATURE

Molecular and spatial signatures of mouse brain aging at single-cell resolution

(2022) William E. Allen et al.   CELL

Single-Cell Transcriptomics Identifies Brain Endothelium Inflammatory Networks in Experimental Autoimmune Encephalomyelitis

(2022) Antoine Philippe Fournier et al.   Neurology-Neuroimmunology & Neuroinflammation

The immune-inflammatory response of oligodendrocytes in a murine model of preterm white matter injury: the role of TLR3 activation

(2021) Marta Boccazzi et al.   Cell Death & Disease

Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age

(2021) Niamh McGarry et al.   BRAIN BEHAVIOR AND IMMUNITY

Next generation of immune checkpoint inhibitors and beyond

(2021) Julian A. Marin-Acevedo et al.   Journal of Hematology & Oncology

Integrated intra‐ and intercellular signaling knowledge for multicellular omics analysis

(2021) Dénes Türei et al.   Molecular Systems Biology

Extraction of nuclei from archived postmortem tissues for single-nucleus sequencing applications

(2021) Malosree Maitra et al.   Nature Protocols

Differences in fatigue-like behavior in the lipopolysaccharide and poly I:C inflammatory animal models

(2021) Catherine G. Foster et al.   PHYSIOLOGY & BEHAVIOR

Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells

(2021) Junji Xing et al.   Nature Communications

Mouse primary microglia respond differently to LPS and poly(I:C) in vitro

(2021) Yingbo He et al.   Scientific Reports

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

The molecular mechanism of RIG‐I activation and signaling*

(2021) Daniel Thoresen et al.   IMMUNOLOGICAL REVIEWS

Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model

(2021) Elena Puris et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Neuroinflammatory astrocyte subtypes in the mouse brain

(2021) Philip Hasel et al.   NATURE NEUROSCIENCE

RNF213 and GUCY1A3 in Moyamoya Disease: Key Regulators of Metabolism, Inflammation, and Vascular Stability

(2021) Yohei Mineharu et al.   Frontiers in Neurology

Inflammation Induces Changes in the Functional Expression of P-gp, BCRP, and MRP2: An Overview of Different Models and Consequences for Drug Disposition

(2021) Sonia Saib et al.   Pharmaceutics

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons

(2020) Corina Nagy et al.   NATURE NEUROSCIENCE

Interferon-induced Protein-44 and Interferon-induced Protein 44-like restrict replication of Respiratory Syncytial Virus

(2020) D. C. Busse et al.   JOURNAL OF VIROLOGY

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

(2020) Anna Ciesielska et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge

(2020) Anat Shemer et al.   IMMUNITY

Single-cell RNA sequencing reveals the diversity of the immunological landscape following CNS infection by a murine coronavirus

(2020) Amber R. Syage et al.   JOURNAL OF VIROLOGY

Maternal immune activation in mice disrupts proteostasis in the fetal brain

(2020) Brian T. Kalish et al.   NATURE NEUROSCIENCE

muscat detects subpopulation-specific state transitions from multi-sample multi-condition single-cell transcriptomics data

(2020) Helena L. Crowell et al.   Nature Communications

PKR: A Kinase to Remember

(2019) Shunit Gal-Ben-Ari et al.   Frontiers in Molecular Neuroscience

Influence of poly(I:C) variability on thermoregulation, immune responses and pregnancy outcomes in mouse models of maternal immune activation

(2019) Flavia S. Mueller et al.   BRAIN BEHAVIOR AND IMMUNITY

Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration

(2019) Carla Ribeiro Alvares Batista et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A key anti-viral protein, RSAD2/VIPERIN, restricts the release of measles virus from infected cells

(2019) Cheyne Kurokawa et al.   VIRUS RESEARCH

Interplay between inflammation and neural plasticity: Both immune activation and suppression impair LTP and BDNF expression

(2019) Maria Teresa Golia et al.   BRAIN BEHAVIOR AND IMMUNITY

Toll-like receptors in the pathogenesis of neuroinflammation

(2019) V. Kumar   JOURNAL OF NEUROIMMUNOLOGY

Cell Type Specific Expression of Toll-Like Receptors in Human Brains and Implications in Alzheimer’s Disease

(2019) Henriette R. Frederiksen et al.   Biomed Research International

Poly(I:C) source, molecular weight and endotoxin contamination affect dam and prenatal outcomes, implications for models of maternal immune activation

(2019) H.M. Kowash et al.   BRAIN BEHAVIOR AND IMMUNITY

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

(2019) Leslie Kirby et al.   Nature Communications

Interferon-Independent Innate Responses to Cytomegalovirus

(2019) Caroline L. Ashley et al.   Frontiers in Immunology

ISG15 in antiviral immunity and beyond

(2018) Yi-Chieh Perng et al.   NATURE REVIEWS MICROBIOLOGY

Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning

(2018) Matthias Weider et al.   Nature Communications

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures

(2018) Carole Sousa et al.   EMBO REPORTS

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

PDGFRβ Cells Rapidly Relay Inflammatory Signal from the Circulatory System to Neurons via Chemokine CCL2

(2018) Lihui Duan et al.   NEURON

The molecular details of cytokine signalling via the JAK/STAT pathway

(2018) Rhiannon Morris et al.   PROTEIN SCIENCE

The functional and inflammatory response of brain endothelial cells to Toll-Like Receptor agonists

(2018) Rebecca H. Johnson et al.   Scientific Reports

Type I interferon pathway in CNS homeostasis and neurological disorders

(2017) Thomas Blank et al.   GLIA

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment

(2016) Thomas Blank et al.   IMMUNITY

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain

(2016) B. B. Lake et al.   SCIENCE

Multiple functions of USP18

(2016) Nadine Honke et al.   Cell Death & Disease

Poly(ADP-ribose) polymerase-13 and RNA regulation in immunity and cancer

(2015) Tanya Todorova et al.   TRENDS IN MOLECULAR MEDICINE

DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation

(2015) Hiroyuki Oshiumi et al.   Cell Reports

Phospholipid transfer protein (PLTP) deficiency impaired blood–brain barrier integrity by increasing cerebrovascular oxidative stress

(2014) Ting Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The different effects of LPS and poly I:C prenatal immune challenges on the behavior, development and inflammatory responses in pregnant mice and their offspring

(2014) Dany Arsenault et al.   BRAIN BEHAVIOR AND IMMUNITY

Antiviral Activity of Human OASL Protein Is Mediated by Enhancing Signaling of the RIG-I RNA Sensor

(2014) Jianzhong Zhu et al.   IMMUNITY

IFITM-Family Proteins: The Cell's First Line of Antiviral Defense

(2014) Charles C. Bailey et al.   Annual Review of Virology

SOCS3, a Major Regulator of Infection and Inflammation

(2014) Berit Carow et al.   Frontiers in Immunology

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Monocyte chemoattractant protein-1 and the blood–brain barrier

(2013) Yao Yao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mx Proteins: Antiviral Gatekeepers That Restrain the Uninvited

(2013) J. Verhelst et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Protocol to Isolate a Large Amount of Functional Oligodendrocyte Precursor Cells from the Cerebral Cortex of Adult Mice and Humans

(2013) Eva María Medina-Rodríguez et al.   PLoS One

Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction

(2012) Jian Ye et al.   BMC BIOINFORMATICS

Oligodendroglia are limited in type I interferon induction and responsiveness in vivo

(2012) Parul Kapil et al.   GLIA

A single intraperitoneal injection of endotoxin in rats induces long-lasting modifications in behavior and brain protein levels of TNF-α and IL-18

(2012) Paola Bossù et al.   Journal of Neuroinflammation

HERC6 Is the Main E3 Ligase for Global ISG15 Conjugation in Mouse Cells

(2012) Diede Oudshoorn et al.   PLoS One

CXCR3 ligands: redundant, collaborative and antagonistic functions

(2011) Joanna R Groom et al.   IMMUNOLOGY AND CELL BIOLOGY

Poly(I:C) promotes TNFα/TNFR1-dependent oligodendrocyte death in mixed glial cultures

(2011) Andrew J Steelman et al.   Journal of Neuroinflammation

Oligodendrocyte Progenitors Reversibly Exit the Cell Cycle and Give Rise to Astrocytes in Response to Interferon- 

(2011) D. C. Tanner et al.   JOURNAL OF NEUROSCIENCE

Toll-like receptors 2 and 3 agonists differentially affect oligodendrocyte survival, differentiation, and myelin membrane formation

(2011) Malika Bsibsi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Inflammation-mediated changes in drug transporter expression/activity: implications for therapeutic drug response

(2011) Alexander M Cressman et al.   Expert Review of Clinical Pharmacology

Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic neurodegeneration

(2010) Robert Field et al.   BRAIN BEHAVIOR AND IMMUNITY

Comparison of anorexia, lethargy, and fever induced by bacterial and viral mimetics in rats

(2009) Nicola Hopwood et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Gamma Interferon Signaling in Oligodendrocytes Is Critical for Protection from Neurotropic Coronavirus Infection

(2009) G. I. Parra et al.   JOURNAL OF VIROLOGY

Tumor Necrosis Factor   Mediates Lipopolysaccharide-Induced Microglial Toxicity to Developing Oligodendrocytes When Astrocytes Are Present

(2008) J. Li et al.   JOURNAL OF NEUROSCIENCE