Antibody and B-cell immune responses against Bordetella pertussis following infection and immunization
出版年份 2023 全文链接
标题
Antibody and B-cell immune responses against Bordetella pertussis following infection and immunization
作者
关键词
-
出版物
JOURNAL OF MOLECULAR BIOLOGY
Volume -, Issue -, Pages 168344
出版商
Elsevier BV
发表日期
2023-11-04
DOI
10.1016/j.jmb.2023.168344
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Immunogenicity and safety of BPZE1, an intranasal live attenuated pertussis vaccine, versus tetanus–diphtheria–acellular pertussis vaccine: a randomised, double-blind, phase 2b trial
- (2023) Cheryl Keech et al. LANCET
- Impact of pregnancy on polyfunctional IgG and memory B cell responses to Tdap immunization
- (2023) Martin Taton et al. VACCINE
- Effect of immunization during pregnancy and pre-existing immunity on diphtheria-tetanus-acellular pertussis vaccine responses in infants
- (2023) Aapo Knuutila et al. Emerging Microbes & Infections
- Systems serology-based comparison of antibody effector functions induced by adjuvanted vaccines to guide vaccine design
- (2023) Carolin Loos et al. npj Vaccines
- Induction of bronchus-associated lymphoid tissue is an early life adaptation for promoting human B cell immunity
- (2023) Rei Matsumoto et al. NATURE IMMUNOLOGY
- Long-Term Analysis of Pertussis Vaccine Immunity to Identify Potential Markers of Vaccine-Induced Memory Associated With Whole Cell But Not Acellular Pertussis Immunization in Mice
- (2022) Kelly L. Weaver et al. Frontiers in Immunology
- BCG-induced trained immunity enhances acellular pertussis vaccination responses in an explorative randomized clinical trial
- (2022) Joshua Gillard et al. npj Vaccines
- Pregnancy enables antibody protection against intracellular infection
- (2022) John J. Erickson et al. NATURE
- How aging impacts vaccine efficacy: known molecular and cellular mechanisms and future directions
- (2022) Judy Chen et al. TRENDS IN MOLECULAR MEDICINE
- Long-lived plasma cells accumulate in the bone marrow at a constant rate from early in an immune response
- (2022) Marcus James Robinson et al. Science Immunology
- The whole-cell pertussis vaccine imposes a broad effector B-cell response in mouse heterologous prime-boost settings
- (2022) Viviana Valeri et al. JCI Insight
- The role of bactericidal and opsonic activity in immunity against Bordetella pertussis
- (2022) Pascal Blanc et al. Expert Review of Vaccines
- Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination
- (2022) Evi van Schuppen et al. Nature Communications
- Responses to an acellular pertussis booster vaccination in children, adolescents, and young and older adults: A collaborative study in Finland, the Netherlands, and the United Kingdom
- (2021) Pauline Versteegen et al. EBioMedicine
- Göttingen Minipigs as a Model to Evaluate Longevity, Functionality, and Memory of Immune Response Induced by Pertussis Vaccines
- (2021) Céline Vaure et al. Frontiers in Immunology
- Memory B cells and plasma cells: The differentiative continuum of humoral immunity
- (2021) Michael P. Cancro et al. IMMUNOLOGICAL REVIEWS
- Pertussis Toxin Promotes Pulmonary Hypertension in an Infant Mouse Model of Bordetella pertussis Infection
- (2021) Karen M Scanlon et al. JOURNAL OF INFECTIOUS DISEASES
- Evaluation of Anti-PT Antibody Response after Pertussis Vaccination and Infection: The Importance of Both Quantity and Quality
- (2021) Alex-Mikael Barkoff et al. Toxins
- Highly Sensitive Flow Cytometry Allows Monitoring of Changes in Circulating Immune Cells in Blood After Tdap Booster Vaccination
- (2021) Annieck M. Diks et al. Frontiers in Immunology
- B-Cell Immunophenotyping to Predict Vaccination Outcome in the Immunocompromised - A Systematic Review
- (2021) Annieck M. Diks et al. Frontiers in Immunology
- Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19
- (2021) Anna H. E. Roukens et al. NATURE IMMUNOLOGY
- 1183. Serum Bactericidal Activity Induced by Live Attenuated Pertussis Vaccine BPZE1 is Comparable to Boostrix™
- (2021) Cheryl A Keech et al. Open Forum Infectious Diseases
- Influence of immune aging on vaccine responses
- (2020) Claire E. Gustafson et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Live attenuated pertussis vaccine BPZE1 induces a broad antibody response in humans
- (2020) Ang Lin et al. JOURNAL OF CLINICAL INVESTIGATION
- Intranasal immunization with outer membrane vesicle pertussis vaccine confers broad protection through mucosal IgA and Th17 responses
- (2020) René H. M. Raeven et al. Scientific Reports
- Profiling avidity of antibodies elicited by vaccination using enzyme-linked immunosorbent assay-based elution – Insights into a novel experimental and analytical approach
- (2020) Bahaa Abu-Raya et al. VACCINE
- Acellular Pertussis Vaccines Induce Anti-pertactin Bactericidal Antibodies Which Drives the Emergence of Pertactin-Negative Strains
- (2020) Elodie Lesne et al. Frontiers in Microbiology
- Update on Transplacental Transfer of IgG Subclasses: Impact of Maternal and Fetal Factors
- (2020) Toby Clements et al. Frontiers in Immunology
- Factors That Influence the Immune Response to Vaccination
- (2019) Petra Zimmermann et al. CLINICAL MICROBIOLOGY REVIEWS
- National Outbreak of Pertussis in England, 2011–2012: A Case-control Study Comparing 3-Component and 5-Component Acellular Vaccines With Whole-cell Pertussis Vaccines
- (2019) Carlos F A Carvalho et al. CLINICAL INFECTIOUS DISEASES
- The effectiveness of maternal pertussis vaccination in protecting newborn infants in Brazil: A case-control study
- (2019) Eder Gatti Fernandes et al. VACCINE
- The evolving nature of Bordetella pertussis in Ontario, Canada, 2009-2017: strains with shifting genotypes and pertactin-deficiency.
- (2019) Raymond S.W. Tsang et al. CANADIAN JOURNAL OF MICROBIOLOGY
- Association of Pertussis Toxin with Severe Pertussis Disease
- (2019) Karen Scanlon et al. Toxins
- Remembrance of Things Past: Long-Term B Cell Memory After Infection and Vaccination
- (2019) Anna-Karin E. Palm et al. Frontiers in Immunology
- Reactivating Immunity Primed by Acellular Pertussis Vaccines in the Absence of Circulating Antibodies: Enhanced Bacterial Control by TLR9 Rather Than TLR4 Agonist-Including Formulation
- (2019) Floriane Auderset et al. Frontiers in Immunology
- Techniques to Study Antigen-Specific B Cell Responses
- (2019) Jim Boonyaratanakornkit et al. Frontiers in Immunology
- Controlled human infection with Bordetella pertussis induces asymptomatic, immunising colonisation
- (2019) H de Graaf et al. CLINICAL INFECTIOUS DISEASES
- The Effect of Timing of Tetanus-Diphtheria-Acellular Pertussis Vaccine Administration in Pregnancy on the Avidity of Pertussis Antibodies
- (2019) Bahaa Abu-Raya et al. Frontiers in Immunology
- A genetically inactivated two-component acellular pertussis vaccine, alone or combined with tetanus and reduced-dose diphtheria vaccines, in adolescents: a phase 2/3, randomised controlled non-inferiority trial
- (2018) Sirintip Sricharoenchai et al. LANCET INFECTIOUS DISEASES
- Molecular and cellular signatures underlying superior immunity against Bordetella pertussis upon pulmonary vaccination
- (2018) R H M Raeven et al. Mucosal Immunology
- The Biology of IgG Subclasses and Their Clinical Relevance to Transplantation
- (2018) Nicole M. Valenzuela et al. TRANSPLANTATION
- Whole-cell or acellular pertussis vaccination in infancy determines IgG subclass profiles to DTaP booster vaccination
- (2018) Saskia van der Lee et al. VACCINE
- Bordetella pertussis isolates vary in their interactions with human complement components
- (2018) Charlotte Brookes et al. Emerging Microbes & Infections
- Robust Humoral and Cellular Immune Responses to Pertussis in Adults After a First Acellular Booster Vaccination
- (2018) Saskia van der Lee et al. Frontiers in Immunology
- Whole-Cell or Acellular Pertussis Primary Immunizations in Infancy Determines Adolescent Cellular Immune Profiles
- (2018) Saskia van der Lee et al. Frontiers in Immunology
- Boosting Teenagers With Acellular Pertussis Vaccines Containing Recombinant or Chemically Inactivated Pertussis Toxin: A Randomized Clinical Trial
- (2018) Geraldine Blanchard Rohner et al. CLINICAL INFECTIOUS DISEASES
- Antibody persistence after vaccination of adolescents with monovalent and combined acellular pertussis vaccines containing genetically inactivated pertussis toxin: a phase 2/3 randomised, controlled, non-inferiority trial
- (2018) Punnee Pitisuttithum et al. LANCET INFECTIOUS DISEASES
- Detection of opsonizing antibodies directed against a recently circulating Bordetella pertussis strain in paired plasma samples from symptomatic and recovered pertussis patients
- (2018) Elise S. Hovingh et al. Scientific Reports
- The establishment of resident memory B cells in the lung requires local antigen encounter
- (2018) S. Rameeza Allie et al. NATURE IMMUNOLOGY
- Burden of Children Hospitalized With Pertussis in Canada in the Acellular Pertussis Vaccine Era, 1999–2015
- (2018) Bahaa Abu-Raya et al. Journal of the Pediatric Infectious Diseases Society
- Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice withBordetella pertussis
- (2017) Mieszko M. Wilk et al. JOURNAL OF IMMUNOLOGY
- Live Attenuated Pertussis Vaccine BPZE1 Protects Baboons Against Bordetella pertussis Disease and Infection
- (2017) Camille Locht et al. JOURNAL OF INFECTIOUS DISEASES
- An update of the global burden of pertussis in children younger than 5 years: a modelling study
- (2017) Karene Hoi Ting Yeung et al. LANCET INFECTIOUS DISEASES
- Effectiveness of Vaccination During Pregnancy to Prevent Infant Pertussis
- (2017) Roger Baxter et al. PEDIATRICS
- A high seroprevalence of antibodies to pertussis toxin among Japanese adults: Qualitative and quantitative analyses
- (2017) Takumi Moriuchi et al. PLoS One
- What Is Wrong with Pertussis Vaccine Immunity?
- (2017) Dimitri A. Diavatopoulos et al. Cold Spring Harbor Perspectives in Biology
- What Is Wrong with Pertussis Vaccine Immunity?
- (2017) Nicolas Burdin et al. Cold Spring Harbor Perspectives in Biology
- Influence of maternal vaccination against diphtheria, tetanus, and pertussis on the avidity of infant antibody responses to a pertussis containing vaccine in Belgium
- (2017) Raïssa Nadège Caboré et al. Virulence
- InvestigatingBordetella pertussiscolonisation and immunity: protocol for an inpatient controlled human infection model
- (2017) Hans de Graaf et al. BMJ Open
- Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface
- (2017) Elise S. Hovingh et al. PLoS Pathogens
- Protection against Pertussis in Humans Correlates to Elevated Serum Antibodies and Memory B Cells
- (2017) Valentina Marcellini et al. Frontiers in Immunology
- Maternal microchimerism is prevalent in cord blood in memory T cells and other cell subsets, and persists post-transplant
- (2017) Sami B. Kanaan et al. OncoImmunology
- Novel Analysis of Immune Cells from Nasal Microbiopsy Demonstrates Reliable, Reproducible Data for Immune Populations, and Superior Cytokine Detection Compared to Nasal Wash
- (2017) Simon P. Jochems et al. PLoS One
- Impact of age and vaccination history on long-term serological responses after symptomatic B. pertussis infection, a high dimensional data analysis
- (2017) Inonge van Twillert et al. Scientific Reports
- A novel high-throughput assay to quantify the vaccine-induced inhibition of Bordetella pertussis adhesion to airway epithelia
- (2016) Elisa Zanaboni et al. BMC MICROBIOLOGY
- Sustained Effectiveness of the Maternal Pertussis Immunization Program in England 3 Years Following Introduction
- (2016) Gayatri Amirthalingam et al. CLINICAL INFECTIOUS DISEASES
- Pertussis: Microbiology, Disease, Treatment, and Prevention
- (2016) Paul E. Kilgore et al. CLINICAL MICROBIOLOGY REVIEWS
- Germinal Center B Cell Dynamics
- (2016) Luka Mesin et al. IMMUNITY
- Complex Antigens Drive Permissive Clonal Selection in Germinal Centers
- (2016) Masayuki Kuraoka et al. IMMUNITY
- Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination
- (2016) Ali H Ellebedy et al. NATURE IMMUNOLOGY
- Pertussis specific cell-mediated immune responses ten years after acellular pertussis booster vaccination in young adults
- (2016) Kirsi Gröndahl-Yli-Hannuksela et al. VACCINE
- Immunological Signatures after Bordetella pertussis Infection Demonstrate Importance of Pulmonary Innate Immune Cells
- (2016) René H. M. Raeven et al. PLoS One
- Poor memory B cell generation contributes to non-protective responses to DTaP vaccine antigens in otitis-prone children
- (2015) S. Basha et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Risk Factors Associated With Infant Deaths From Pertussis: A Case-Control Study
- (2015) Kathleen Winter et al. CLINICAL INFECTIOUS DISEASES
- Impaired NK Cell Responses to Pertussis and H1N1 Influenza Vaccine Antigens in Human Cytomegalovirus-Infected Individuals
- (2015) Carolyn M. Nielsen et al. JOURNAL OF IMMUNOLOGY
- Bordetella pertussisAdenylate Cyclase Toxin Blocks Induction of Bactericidal Nitric Oxide in Macrophages through cAMP-Dependent Activation of the SHP-1 Phosphatase
- (2015) Ondrej Cerny et al. JOURNAL OF IMMUNOLOGY
- Complement evasion by Bordetella pertussis: implications for improving current vaccines
- (2015) Ilse Jongerius et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Pertussis Resurgence Associated with Pertactin-Deficient and Genetically Divergent Bordetella Pertussis Isolates in Israel
- (2015) Ellen Bamberger et al. PEDIATRIC INFECTIOUS DISEASE JOURNAL
- Immunization of pregnant women against pertussis: The effect of timing on antibody avidity
- (2015) Bahaa Abu Raya et al. VACCINE
- What to do about pertussis vaccines? Linking what we know about pertussis vaccine effectiveness, immunology and disease transmission to create a better vaccine: Graphical Abstract Figure.
- (2015) Shelly Bolotin et al. Pathogens and Disease
- Waning and aging of cellular immunity toB. pertussis
- (2015) Inonge van Twillert et al. Pathogens and Disease
- Review of the neutrophil response toBordetella pertussisinfection
- (2015) Joshua C. Eby et al. Pathogens and Disease
- TheBordetella pertussis Bps polysaccharide enhances lung colonization by conferring protection from complement-mediated killing
- (2014) Tridib Ganguly et al. CELLULAR MICROBIOLOGY
- Pertussis-Specific Memory B-Cell and Humoral IgG Responses in Adolescents after a Fifth Consecutive Dose of Acellular Pertussis Vaccine
- (2014) Maja Jahnmatz et al. Clinical and Vaccine Immunology
- Pertussis Pathogenesis--What We Know and What We Don't Know
- (2014) E. L. Hewlett et al. JOURNAL OF INFECTIOUS DISEASES
- Effectiveness of maternal pertussis vaccination in England: an observational study
- (2014) Gayatri Amirthalingam et al. LANCET
- Rapid development of broadly influenza neutralizing antibodies through redundant mutations
- (2014) Leontios Pappas et al. NATURE
- Bordetella pertussis pathogenesis: current and future challenges
- (2014) Jeffrey A. Melvin et al. NATURE REVIEWS MICROBIOLOGY
- Age Related Differences in Dynamics of Specific Memory B Cell Populations after Clinical Pertussis Infection
- (2014) Inonge van Twillert et al. PLoS One
- B-cell responses after intranasal vaccination with the novel attenuated Bordetella pertussis vaccine strain BPZE1 in a randomized phase I clinical trial
- (2014) Maja Jahnmatz et al. VACCINE
- Humoral and B-cell memory responses in children five years after pertussis acellular vaccine priming
- (2014) Maria Carollo et al. VACCINE
- Affinity Enhancement of Antibodies: How Low-Affinity Antibodies Produced Early in Immune Responses Are Followed by High-Affinity Antibodies Later and in Memory B-Cell Responses
- (2014) H. N. Eisen Cancer Immunology Research
- Differential T- and B-Cell Responses to Pertussis in Acellular Vaccine-Primed versus Whole-Cell Vaccine-Primed Children 2 Years after Preschool Acellular Booster Vaccination
- (2013) Rose-Minke Schure et al. Clinical and Vaccine Immunology
- Differential activation of CD57-defined natural killer cell subsets during recall responses to vaccine antigens
- (2013) Matthew J. White et al. IMMUNOLOGY
- Optimization of a human IgG B-cell ELISpot assay for the analysis of vaccine-induced B-cell responses
- (2013) Maja Jahnmatz et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Immune Responses to Pertussis Vaccines and Disease
- (2013) K. M. Edwards et al. JOURNAL OF INFECTIOUS DISEASES
- Infection with 2009 H1N1 Influenza Virus Primes for Immunological Memory in Human Nose-Associated Lymphoid Tissue, Offering Cross-Reactive Immunity to H1N1 and Avian H5N1 Viruses
- (2013) W. H. Mahallawi et al. JOURNAL OF VIROLOGY
- Waning Immunity to Pertussis Following 5 Doses of DTaP
- (2013) S. Y. Tartof et al. PEDIATRICS
- Genome-Wide Gene Expression Analysis of Bordetella pertussis Isolates Associated with a Resurgence in Pertussis: Elucidation of Factors Involved in the Increased Fitness of Epidemic Strains
- (2013) Audrey J. King et al. PLoS One
- Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model
- (2013) J. M. Warfel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Characteristics of Severe Bordetella pertussis Infection Among Infants
- (2013) E. L. Murray et al. Journal of the Pediatric Infectious Diseases Society
- Unexpectedly Limited Durability of Immunity Following Acellular Pertussis Vaccination in Preadolescents in a North American Outbreak
- (2012) Maxwell A. Witt et al. CLINICAL INFECTIOUS DISEASES
- Association of Childhood Pertussis With Receipt of 5 Doses of Pertussis Vaccine by Time Since Last Vaccine Dose, California, 2010
- (2012) Lara K. Misegades et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- California Pertussis Epidemic, 2010
- (2012) Kathleen Winter et al. JOURNAL OF PEDIATRICS
- Immunity to the respiratory pathogen Bordetella pertussis
- (2012) R Higgs et al. Mucosal Immunology
- Waning Protection after Fifth Dose of Acellular Pertussis Vaccine in Children
- (2012) Nicola P. Klein et al. NEW ENGLAND JOURNAL OF MEDICINE
- Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection
- (2012) T. Onodera et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differences in avidity of IgG antibodies to pertussis toxin after acellular pertussis booster vaccination and natural infection
- (2012) Alex-Mikael Barkoff et al. VACCINE
- Differences of IgG antibody avidity after an acellular pertussis (aP) booster in adolescents after a whole cell (wcP) or aP primary vaccination
- (2012) M. Prelog et al. VACCINE
- Immunization of Teenagers with a Fifth Dose of Reduced DTaP-IPV Induces High Levels of Pertussis Antibodies with a Significant Increase in Opsonophagocytic Activity
- (2011) Audun Aase et al. Clinical and Vaccine Immunology
- BapC autotransporter protein is a virulence determinant of Bordetella pertussis
- (2011) Mojtaba Noofeli et al. MICROBIAL PATHOGENESIS
- Bordetella pertussis Autotransporter Vag8 Binds Human C1 Esterase Inhibitor and Confers Serum Resistance
- (2011) Nico Marr et al. PLoS One
- Serum IgA Responses against Pertussis Proteins in Infected and Dutch wP or aP Vaccinated Children: An Additional Role in Pertussis Diagnostics
- (2011) Lotte H. Hendrikx et al. PLoS One
- Induction of Bordetella pertussis-specific immune memory by DTPa vaccines
- (2011) Sandra Morel et al. VACCINE
- Impact of infant and preschool pertussis vaccinations on memory B-cell responses in children at 4 years of age
- (2011) Lotte H. Hendrikx et al. VACCINE
- Different IgG-subclass distributions after whole-cell and acellular pertussis infant primary vaccinations in healthy and pertussis infected children
- (2011) Lotte H. Hendrikx et al. VACCINE
- Enhanced memory B-cell immune responses after a second acellular pertussis booster vaccination in children 9 years of age
- (2011) Lotte H. Hendrikx et al. VACCINE
- Pertussis serology: assessment of IgG anti-PT ELISA for replacement of the CHO cell assay*
- (2010) TINE DALBY et al. APMIS
- A Live, AttenuatedBordetella pertussisVaccine Provides Long-Term Protection against Virulent Challenge in a Murine Model
- (2010) Ciaran M. Skerry et al. Clinical and Vaccine Immunology
- Pertactin Is Required for Bordetella Species To Resist Neutrophil-Mediated Clearance
- (2010) C. S. Inatsuka et al. INFECTION AND IMMUNITY
- NK Cells as Effectors of Acquired Immune Responses: Effector CD4+ T Cell-Dependent Activation of NK Cells Following Vaccination
- (2010) A. Horowitz et al. JOURNAL OF IMMUNOLOGY
- Antibody responses to pertussis toxin display different kinetics after clinical Bordetella pertussis infection than after vaccination with an acellular pertussis vaccine
- (2010) T. Dalby et al. JOURNAL OF MEDICAL MICROBIOLOGY
- Clinical Characteristics and Outcomes of Neonatal Pertussis: A Comparative Study
- (2010) Luis A. Castagnini et al. JOURNAL OF PEDIATRICS
- Interactions between Bordetella pertussis and the complement inhibitor factor H
- (2010) Hanne Amdahl et al. MOLECULAR IMMUNOLOGY
- The Bps polysaccharide of Bordetella pertussis promotes colonization and biofilm formation in the nose by functioning as an adhesin
- (2010) Matt S. Conover et al. MOLECULAR MICROBIOLOGY
- Impaired long-term maintenance and function of Bordetella pertussis specific B cell memory
- (2010) Rachel M. Stenger et al. VACCINE
- Identifying long-term memory B-cells in vaccinated children despite waning antibody levels specific for Bordetella pertussis proteins
- (2010) Lotte H. Hendrikx et al. VACCINE
- Long-term presence of memory B-cells specific for different vaccine components
- (2009) A.M. Buisman et al. VACCINE
- Pathology and Pathogenesis of FatalBordetella pertussisInfection in Infants
- (2008) Christopher D. Paddock et al. CLINICAL INFECTIOUS DISEASES
- Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
- (2008) Jens Wrammert et al. NATURE
- Differences of humoral and cellular immune response to an acellular pertussis booster in adolescents with a whole cell or acellular primary vaccination
- (2008) Nikolaus Rieber et al. VACCINE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started