Intranasal immunization with outer membrane vesicle pertussis vaccine confers broad protection through mucosal IgA and Th17 responses

The Role of Mucosal Immunity in Pertussis

(2019) Luis Solans et al.   Frontiers in Immunology

Antibody Specificity Following a Recent Bordetella pertussis Infection in Adolescence Is Correlated With the Pertussis Vaccine Received in Childhood

(2019) René H. M. Raeven et al.   Frontiers in Immunology

LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice

(2019) E. Valli et al.   Scientific Reports

Controlling pertussis: how can we do it? A focus on immunization

(2018) Federico Martinón-Torres et al.   Expert Review of Vaccines

Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant

(2018) Wei Shi et al.   IMMUNOLOGY LETTERS

Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters

(2018) Ricardo da Silva Antunes et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of a thermostable spray dried outer membrane vesicle pertussis vaccine for pulmonary immunization

(2018) Gaurav Kanojia et al.   JOURNAL OF CONTROLLED RELEASE

IL-17-dependent SIgA-mediated protection against nasal Bordetella pertussis infection by live attenuated BPZE1 vaccine

(2018) Luis Solans et al.   Mucosal Immunology

Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting TRM cells

(2018) Aideen C. Allen et al.   Mucosal Immunology

Detection of opsonizing antibodies directed against a recently circulating Bordetella pertussis strain in paired plasma samples from symptomatic and recovered pertussis patients

(2018) Elise S. Hovingh et al.   Scientific Reports

The establishment of resident memory B cells in the lung requires local antigen encounter

(2018) S. Rameeza Allie et al.   NATURE IMMUNOLOGY

Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice withBordetella pertussis

(2017) Mieszko M. Wilk et al.   JOURNAL OF IMMUNOLOGY

Protective effects of in vivo -expressed autotransporters against Bordetella pertussis infection

(2017) Koichiro Suzuki et al.   MICROBIOLOGY AND IMMUNOLOGY

Molecular and cellular signatures underlying superior immunity against Bordetella pertussis upon pulmonary vaccination

(2017) R HM Raeven et al.   Mucosal Immunology

What Is Wrong with Pertussis Vaccine Immunity?

(2017) Nicolas Burdin et al.   Cold Spring Harbor Perspectives in Biology

Safety Profile and Immunologic Responses of a Novel Vaccine Against Shigella sonnei Administered Intramuscularly, Intradermally and Intranasally: Results From Two Parallel Randomized Phase 1 Clinical Studies in Healthy Adult Volunteers in Europe

(2017) Odile Launay et al.   EBioMedicine

Outer membrane vesicles: an attractive candidate for pertussis vaccines

(2016) Daniela F Hozbor   Expert Review of Vaccines

Characterization of the immune response induced by pertussis OMVs-based vaccine

(2016) D. Bottero et al.   VACCINE

Immunological Signatures after Bordetella pertussis Infection Demonstrate Importance of Pulmonary Innate Immune Cells

(2016) René H. M. Raeven et al.   PLoS One

Bordetella pertussis outer membrane vesicle vaccine confers equal efficacy in mice with milder inflammatory responses compared to a whole-cell vaccine

(2016) René H. M. Raeven et al.   Scientific Reports

Biosynthetically engineered lipopolysaccharide as vaccine adjuvant

(2015) Afshin Zariri et al.   Expert Review of Vaccines

Immunoproteomic Profiling of Bordetella pertussis Outer Membrane Vesicle Vaccine Reveals Broad and Balanced Humoral Immunogenicity

(2015) René H. M. Raeven et al.   JOURNAL OF PROTEOME RESEARCH

Antiviral B cell and T cell immunity in the lungs

(2015) Christopher Chiu et al.   NATURE IMMUNOLOGY

The emerging role of resident memory T cells in protective immunity and inflammatory disease

(2015) Chang Ook Park et al.   NATURE MEDICINE

Roads to the development of improved pertussis vaccines paved by immunology

(2015) Jolanda Brummelman et al.   Pathogens and Disease

Importance of (antibody-dependent) complement-mediated serum killing in protection againstBordetella pertussis

(2014) Jeroen Geurtsen et al.   Expert Review of Vaccines

Nonhuman Primate and Human Challenge Models of Pertussis

(2014) T. J. Merkel et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular Signatures of the Evolving Immune Response in Mice following a Bordetella pertussis Infection

(2014) René H. M. Raeven et al.   PLoS One

Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model

(2013) J. M. Warfel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CpG-containing oligodeoxynucleotide adjuvant for acellular pertussis vaccine improves the protective response againstBordetella pertussis

(2013) Catpagavalli Asokanathan et al.   Human Vaccines & Immunotherapeutics

Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine

(2013) Pádraig J. Ross et al.   PLoS Pathogens

Re-emergence of pertussis: what are the solutions?

(2012) Romina Libster et al.   Expert Review of Vaccines

Bordetella pertussis infection induces a mucosal IL-17 response and long-lived Th17 and Th1 immune memory cells in nonhuman primates

(2012) J M Warfel et al.   Mucosal Immunology

Oligosaccharide conjugates of Bordetella pertussis and bronchiseptica induce bactericidal antibodies, an addition to pertussis vaccine

(2011) J. Kubler-Kielb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Outer membrane vesicles obtained from Bordetella pertussis Tohama expressing the lipid A deacylase PagL as a novel acellular vaccine candidate

(2011) Cristian J.A. Asensio et al.   VACCINE

Nasal vaccine innovation

(2010) Inderjit Jabbal-Gill   JOURNAL OF DRUG TARGETING

Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin

(2009) David J. M. Lewis et al.   PLoS One

Protective activity of the Bordetella pertussis BrkA autotransporter in the murine lung colonization model

(2008) Nico Marr et al.   VACCINE

Outer membrane vesicles as acellular vaccine against pertussis

(2008) Roy Roberts et al.   VACCINE