Prioritizing Cardiovascular Disease-Associated Variants Altering NKX2-5 and TBX5 Binding through an Integrative Computational Approach

Disease-associated non-coding variants alter NKX2-5 DNA-binding affinity

(2023) Edwin G. Peña-Martínez et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Integrating functional scoring and regulatory data to predict the effect of non-coding SNPs in a complex neurological disease

(2023) Daniela Felício et al.   Briefings in Functional Genomics

Role of non‐coding variants in cardiovascular disease

(2023) Katayoun Heshmatzad et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Transcription factor protein interactomes reveal genetic determinants in heart disease

(2022) Barbara Gonzalez-Teran et al.   CELL

CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart

(2022) Zachary L. Robbe et al.   GENES & DEVELOPMENT

ChIP-Atlas 2021 update: a data-mining suite for exploring epigenomic landscapes by fully integrating ChIP-seq, ATAC-seq and Bisulfite-seq data

(2022) Zhaonan Zou et al.   NUCLEIC ACIDS RESEARCH

Machine Learning Prediction of Non-Coding Variant Impact in Human Retinal cis-Regulatory Elements

(2022) Leah S. VandenBosch et al.   Translational Vision Science & Technology

Epidemiology of cardiovascular disease in Europe

(2021) Nick Townsend et al.   Nature Reviews Cardiology

Variants in a cis-regulatory element of TBX1 in conotruncal heart defect patients impair GATA6-mediated transactivation

(2021) Xuechao Jiang et al.   Orphanet Journal of Rare Diseases

AtheroSpectrum Reveals Novel Macrophage Foam Cell Gene Signatures Associated With Atherosclerotic Cardiovascular Disease Risk

(2021) Chuan Li et al.   CIRCULATION

Prioritization of regulatory variants with tissue-specific function in the non-coding regions of human genome

(2021) Shengcheng Dong et al.   NUCLEIC ACIDS RESEARCH

ReMap 2022: a database of Human, Mouse, Drosophila and Arabidopsis regulatory regions from an integrative analysis of DNA-binding sequencing experiments

(2021) Fayrouz Hammal et al.   NUCLEIC ACIDS RESEARCH

LDlinkR: An R Package for Rapidly Calculating Linkage Disequilibrium Statistics in Diverse Populations

(2020) Timothy A. Myers et al.   Frontiers in Genetics

Cardiovascular Diseases in Sub-Saharan Africa Compared to High-Income Countries: An Epidemiological Perspective

(2020) Matthew Fomonyuy Yuyun et al.   Global Heart

Global reference mapping of human transcription factor footprints

(2020) Jeff Vierstra et al.   NATURE

The contribution of non-coding regulatory elements to cardiovascular disease

(2020) Diego Villar et al.   Open Biology

Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction

(2020) Jan Hendrik van Weerd et al.   eLife

Allele-specific NKX2-5 binding underlies multiple genetic associations with human electrocardiographic traits

(2019) Paola Benaglio et al.   NATURE GENETICS

Exploring Shared Susceptibility between Two Neural Crest Cells Originating Conditions: Neuroblastoma and Congenital Heart Disease

(2019) Alessandro Testori et al.   Genes

The Global Burden of Cardiovascular Diseases and Risk Factors

(2019) George A. Mensah et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability

(2016) Elisabeth M. Lodder et al.   AMERICAN JOURNAL OF HUMAN GENETICS

gkmSVM: an R package for gapped-kmer SVM

(2016) Mahmoud Ghandi et al.   BIOINFORMATICS

LS-GKM: a new gkm-SVM for large-scale datasets

(2016) Dongwon Lee   BIOINFORMATICS

Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis

(2016) Yen-Sin Ang et al.   CELL

Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis

(2016) Luis Luna-Zurita et al.   CELL

The Genetics of Transcription Factor DNA Binding Variation

(2016) Bart Deplancke et al.   CELL

Role of non-coding sequence variants in cancer

(2016) Ekta Khurana et al.   NATURE REVIEWS GENETICS

Genome-wide compendium and functional assessment of in vivo heart enhancers

(2016) Diane E. Dickel et al.   Nature Communications

Non-coding genetic variants in human disease: Figure 1.

(2015) Feng Zhang et al.   HUMAN MOLECULAR GENETICS

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

The MEME Suite

(2015) Timothy L. Bailey et al.   NUCLEIC ACIDS RESEARCH

Art27 Interacts with GATA4, FOG2 and NKX2.5 and Is a Novel Co-Repressor of Cardiac Genes

(2014) Daniel R. Carter et al.   PLoS One

Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways

(2014) Benoit Ballester et al.   eLife

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Signaling and Transcriptional Networks in Heart Development and Regeneration

(2013) B. G. Bruneau   Cold Spring Harbor Perspectives in Biology

Crystal Structure of the Human NKX2.5 Homeodomain in Complex with DNA Target

(2012) Lagnajeet Pradhan et al.   BIOCHEMISTRY

Genetics of Human Cardiovascular Disease

(2012) Sekar Kathiresan et al.   CELL

Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease

(2012) Scott Smemo et al.   HUMAN MOLECULAR GENETICS

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Differential Role of Nkx2-5 in Activation of the Atrial Natriuretic Factor Gene in the Developing versus Failing Heart

(2011) S. A. Warren et al.   MOLECULAR AND CELLULAR BIOLOGY

Dinucleotide Weight Matrices for Predicting Transcription Factor Binding Sites: Generalizing the Position Weight Matrix

(2010) Rahul Siddharthan   PLoS One

Cooperative interaction ofNkx2.5andMef2ctranscription factors during heart development

(2008) Joshua W. Vincentz et al.   DEVELOPMENTAL DYNAMICS