Spinster homolog 2 reduces malignancies of glioblastoma via PTEN/PI3K/AKT pathway

Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate

(2023) Hongwen Chen et al.   CELL

Profile of sphingolipid-related genes and its association with prognosis highlights sphingolipid metabolism in oral cancer

(2021) Gabriel da Silva et al.   Cancer Biomarkers

Sphingosine-1-phosphate transporter spinster homologue 2 is essential for iron-regulated metastasis of hepatocellular carcinoma

(2021) Min Li et al.   MOLECULAR THERAPY

SPNS2 enables T cell egress from lymph nodes during an immune response

(2021) Martyna Okuniewska et al.   Cell Reports

SPNS2 Downregulation Induces EMT and Promotes Colorectal Cancer Metastasis via Activating AKT Signaling Pathway

(2021) Lei Lv et al.   Frontiers in Oncology

The Glioma Stem Cell Model in the Era of Single-Cell Genomics

(2020) Mario L. Suvà et al.   CANCER CELL

Stories of spinster with various faces: from courtship rejection to tumor metastasis rejection

(2019) Yoshiro Nakano   JOURNAL OF NEUROGENETICS

Mining TCGA database for genes of prognostic value in glioblastoma microenvironment

(2018) Di Jia et al.   Aging-US

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

(2018) Tathiane M. Malta et al.   CELL

S1P transporter SPNS2 regulates proper postnatal retinal morphogenesis

(2018) Chao Fang et al.   FASEB JOURNAL

Sphingosine 1-phosphate stimulates eyelid closure in the developing rat by stimulating EGFR signaling

(2018) Ganlan Bian et al.   Science Signaling

Adult Glioblastoma

(2017) Brian M. Alexander et al.   JOURNAL OF CLINICAL ONCOLOGY

Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth

(2016) Baoli Hu et al.   CELL

Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

(2015) Michael S. Donoviel et al.   FASEB JOURNAL

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

(2015) Jeanette E. Eckel-Passow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells

(2014) Leyre Brizuela et al.   Molecular Oncology

Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling

(2014) Feng Hu et al.   NEURO-ONCOLOGY

Critical Role of Spns2, a Sphingosine-1-Phosphate Transporter, in Lung Cancer Cell Survival and Migration

(2014) Eric Bradley et al.   PLoS One

Spinster Homolog 2 (Spns2) Deficiency Causes Early Onset Progressive Hearing Loss

(2014) Jing Chen et al.   PLoS Genetics

An Epithelial-Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

(2012) L. A. Byers et al.   CLINICAL CANCER RESEARCH

Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network

(2012) Masayuki Nagahashi et al.   FASEB JOURNAL

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

(2012) Shigetomo Fukuhara et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of Sphingosine-1-Phosphate Transporter Spns2 in Immune System Function

(2012) A. Nijnik et al.   JOURNAL OF IMMUNOLOGY

Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells

(2012) Yu Hisano et al.   PLoS One

Increased Microglia/Macrophage Gene Expression in a Subset of Adult and Pediatric Astrocytomas

(2012) Jane R. Engler et al.   PLoS One

Acetylation of sphingosine kinase 1 regulates cell growth and cell-cycle progression

(2011) Hongyang Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

(2009) Anne-Marie Bleau et al.   Cell Stem Cell

The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

(2008) A. Kawahara et al.   SCIENCE