SPNS2 Downregulation Induces EMT and Promotes Colorectal Cancer Metastasis via Activating AKT Signaling Pathway

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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Colorectal cancer statistics, 2020

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Visualizing and interpreting cancer genomics data via the Xena platform

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Hepatic lipids promote liver metastasis

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Spinster homolog 2 in cancers, its functions and mechanisms

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AKT as a Therapeutic Target for Cancer

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Akt in cancer: Mediator and more

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Roles of sphingosine-1-phosphate signaling in cancer

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The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma

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Epithelial Mesenchymal Transition in Tumor Metastasis

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Re-evaluating the role of FOXOs in cancer

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Emerging roles of lipid metabolism in cancer metastasis

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Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

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Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC

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Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis

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Downregulation of MicroRNA-644a Promotes Esophageal Squamous Cell Carcinoma Aggressiveness and Stem Cell–like Phenotype via Dysregulation of PITX2

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Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium

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Targeting metastasis-initiating cells through the fatty acid receptor CD36

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Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances

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Quantification of sphingosine 1-phosphate by validated LC-MS/MS method revealing strong correlation with apolipoprotein M in plasma but not in serum due to platelet activation during blood coagulation

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Intracellular sphingosine kinase 2–derived sphingosine-1-phosphate mediates epidermal growth factor–induced ezrin-radixin-moesin phosphorylation and cancer cell invasion

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Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

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Systematic review of surgical management of synchronous colorectal liver metastases

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Export of sphingosine-1-phosphate and cancer progression

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Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells

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K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5

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Molecular mechanisms of epithelial–mesenchymal transition

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Critical Role of Spns2, a Sphingosine-1-Phosphate Transporter, in Lung Cancer Cell Survival and Migration

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The DNA methylation-regulated miR-193a-3p dictates the multi-chemoresistance of bladder cancer via repression of SRSF2/PLAU/HIC2 expression

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EMT is the dominant program in human colon cancer

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Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition

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Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

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The Paradox of Akt-mTOR Interactions

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Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis

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An Epithelial-Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

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Site-specific Phosphorylation of the p65 Protein Subunit Mediates Selective Gene Expression by Differential NF-κB and RNA Polymerase II Promoter Recruitment

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The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

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Dysplasia-Carcinoma Transition Specific Transcripts in Colonic Biopsy Samples

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Akt, FoxO and regulation of apoptosis

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DNA Methylation-regulated miR-193a-3p Dictates Resistance of Hepatocellular Carcinoma to 5-Fluorouracil via Repression of SRSF2 Expression

(2011) Kelong Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

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Experimentally Derived Metastasis Gene Expression Profile Predicts Recurrence and Death in Patients With Colon Cancer

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Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a

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