In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g

Innate immune evasion strategies of SARS-CoV-2

(2023) Judith M. Minkoff et al.   NATURE REVIEWS MICROBIOLOGY

Structural insights into the activity regulation of full-length non-structural protein 1 from SARS-CoV-2

(2023) Ying Wang et al.   STRUCTURE

SARS-CoV-2 NSP1 induces mRNA cleavages on the ribosome

(2023) Yann Tardivat et al.   NUCLEIC ACIDS RESEARCH

Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal

(2022) Prateek Kumar et al.   RSC Advances

Artesunate induces substantial topological alterations in the SARS-CoV-2 Nsp1 protein structure

(2022) Arun Bahadur Gurung et al.   JOURNAL OF KING SAUD UNIVERSITY SCIENCE

Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells

(2022) Hannah M. Burgess et al.   GENES & DEVELOPMENT

Parsing the role of NSP1 in SARS-CoV-2 infection

(2022) Tal Fisher et al.   Cell Reports

Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

(2022) Mohammad Afsar et al.   eLife

Synergistic interactions of repurposed drugs that inhibit Nsp1, a major virulence factor for COVID-19

(2022) Hung-Teh Kao et al.   Scientific Reports

Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography

(2022) Alberto Borsatto et al.   eLife

Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation

(2021) Christopher P. Lapointe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression

(2021) Ke Zhang et al.   Science Advances

Mechanisms of Coronavirus Nsp1-Mediated Control of Host and Viral Gene Expression

(2021) Keisuke Nakagawa et al.   Cells

SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis

(2021) Yaara Finkel et al.   NATURE

The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression

(2021) Aaron S. Mendez et al.   Cell Reports

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

(2020) Matthias Thoms et al.   SCIENCE

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

(2020) Abhik K. Banerjee et al.   CELL

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

(2020) Katharina Schubert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a human 48S translational initiation complex

(2020) Jailson Brito Querido et al.   SCIENCE

Structure of nonstructural protein 1 from SARS-CoV-2.

(2020) Lauren K. Clark et al.   JOURNAL OF VIROLOGY

Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA

(2020) Shuai Yuan et al.   MOLECULAR CELL

Structural characterization of nonstructural protein 1 from SARS-CoV-2

(2020) Cameron Semper et al.   iScience

A conserved region of nonstructural protein 1 from alphacoronaviruses inhibits host gene expression and is critical for viral virulence

(2019) Zhou Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rethinking Drugs from Chemistry to Therapeutic Opportunities: Pixantrone beyond Anthracyclines

(2016) Pierantonio Menna et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Toward the mechanism of eIF4F-mediated ribosomal attachment to mammalian capped mRNAs

(2016) Parimal Kumar et al.   GENES & DEVELOPMENT

Mitoxantrone, More than Just Another Topoisomerase II Poison

(2015) Benny J. Evison et al.   MEDICINAL RESEARCH REVIEWS

Structure of mammalian eIF3 in the context of the 43S preinitiation complex

(2015) Amedee des Georges et al.   NATURE

Emerging roles for RNA degradation in viral replication and antiviral defense

(2015) Emma Abernathy et al.   VIROLOGY

Initiation of Translation by Cricket Paralysis Virus IRES Requires Its Translocation in the Ribosome

(2014) Israel S. Fernández et al.   CELL

Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29

(2013) Yaser Hashem et al.   CELL

Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit

(2013) Yaser Hashem et al.   NATURE

Severe Acute Respiratory Syndrome Coronavirus Protein nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation

(2012) K. G. Lokugamage et al.   JOURNAL OF VIROLOGY

A Common Strategy for Host RNA Degradation by Divergent Viruses

(2012) M. M. Gaglia et al.   JOURNAL OF VIROLOGY

Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems

(2012) Yutaka Muto et al.   Wiley Interdisciplinary Reviews-RNA

Structural analysis of an eIF3 subcomplex reveals conserved interactions required for a stable and proper translation pre-initiation complex assembly

(2011) Anna Herrmannová et al.   NUCLEIC ACIDS RESEARCH

Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit

(2011) Margarita Muhs et al.   NUCLEIC ACIDS RESEARCH

SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

(2011) Cheng Huang et al.   PLoS Pathogens

Bypassing of stems versus linear base-by-base inspection of mammalian mRNAs during ribosomal scanning

(2010) Irina S Abaeva et al.   EMBO JOURNAL

The RNA Recognition Motif of Eukaryotic Translation Initiation Factor 3g (eIF3g) Is Required for Resumption of Scanning of Posttermination Ribosomes for Reinitiation on GCN4 and Together with eIF3i Stimulates Linear Scanning

(2010) L. Cuchalova et al.   MOLECULAR AND CELLULAR BIOLOGY

Nucleases: diversity of structure, function and mechanism

(2010) Wei Yang   QUARTERLY REVIEWS OF BIOPHYSICS

A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein

(2009) Wataru Kamitani et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

(2008) K. Narayanan et al.   JOURNAL OF VIROLOGY