Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1

(2020) Jasenko Zivanov et al.   IUCrJ

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

(2020) Canrong Wu et al.   Acta Pharmaceutica Sinica B

Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes

(2020) Varun Bhaskar et al.   Cell Reports

A TRIM32-AMBRA1-ULK1 complex initiates the autophagy response in atrophic muscle cells

(2019) Martina Di Rienzo et al.   Autophagy

LYAR suppresses interferon-β induction by targeting phosphorylated IRF3

(2019) Cha Yang et al.   JOURNAL OF VIROLOGY

Visualizing late states of human 40S ribosomal subunit maturation

(2018) Michael Ameismeier et al.   NATURE

Lso2 is a conserved ribosome-bound protein required for translational recovery in yeast

(2018) Yinuo J. Wang et al.   PLOS BIOLOGY

Origin and evolution of pathogenic coronaviruses

(2018) Jie Cui et al.   NATURE REVIEWS MICROBIOLOGY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination

(2017) Yong Hu et al.   JOURNAL OF VIROLOGY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae

(2017) André Heuer et al.   eLife

Recent developments in the CCP-EM software suite

(2017) Tom Burnley et al.   Acta Crystallographica Section D-Structural Biology

TRIM23 mediates virus-induced autophagy via activation of TBK1

(2017) Konstantin M. J. Sparrer et al.   Nature Microbiology

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

SARS and MERS: recent insights into emerging coronaviruses

(2016) Emmie de Wit et al.   NATURE REVIEWS MICROBIOLOGY

DelPhi Web Server: A Comprehensive Online Suite for Electrostatic Calculations of Biological Macromolecules and Their Complexes

(2016) Subhra Sarkar et al.   Communications in Computational Physics

Intracellular detection of viral nucleic acids

(2015) Konstantin MJ Sparrer et al.   CURRENT OPINION IN MICROBIOLOGY

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex

(2015) Jose L. Llácer et al.   MOLECULAR CELL

Structural basis for stop codon recognition in eukaryotes

(2015) Alan Brown et al.   NATURE

Structure of mammalian eIF3 in the context of the 43S preinitiation complex

(2015) Amedee des Georges et al.   NATURE

Structure of a human translation termination complex

(2015) Sarah Matheisl et al.   NUCLEIC ACIDS RESEARCH

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

(2015) Carmela Sidrauski et al.   eLife

Human cell growth regulator Ly-1 antibody reactive homologue accelerates processing of preribosomal RNA

(2014) Naoki Miyazawa et al.   GENES TO CELLS

Cryoelectron Microscopic Structures of Eukaryotic Translation Termination Complexes Containing eRF1-eRF3 or eRF1-ABCE1

(2014) Anne Preis et al.   Cell Reports

Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29

(2013) Yaser Hashem et al.   CELL

Attenuation of Mouse Hepatitis Virus by Deletion of the LLRKxGxKG Region of Nsp1

(2013) Lin Lei et al.   PLoS One

Identification of Residues of SARS-CoV nsp1 That Differentially Affect Inhibition of Gene Expression and Antiviral Signaling

(2013) Andrew R. Jauregui et al.   PLoS One

Severe Acute Respiratory Syndrome Coronavirus Protein nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation

(2012) K. G. Lokugamage et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp1 Facilitates Efficient Propagation in Cells through a Specific Translational Shutoff of Host mRNA

(2012) T. Tanaka et al.   JOURNAL OF VIROLOGY

Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus

(2012) P. C. Y. Woo et al.   JOURNAL OF VIROLOGY

Structural basis of highly conserved ribosome recycling in eukaryotes and archaea

(2012) Thomas Becker et al.   NATURE

Measles Virus C Protein Interferes with Beta Interferon Transcription in the Nucleus

(2011) K. M. J. Sparrer et al.   JOURNAL OF VIROLOGY

SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

(2011) Cheng Huang et al.   PLoS Pathogens

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Alphacoronavirus Transmissible Gastroenteritis Virus nsp1 Protein Suppresses Protein Translation in Mammalian Cells and in Cell-Free HeLa Cell Extracts but Not in Rabbit Reticulocyte Lysate

(2010) C. Huang et al.   JOURNAL OF VIROLOGY

Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses

(2009) Y. Tohya et al.   JOURNAL OF VIROLOGY

A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein

(2009) Wataru Kamitani et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

(2008) K. Narayanan et al.   JOURNAL OF VIROLOGY