Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Chemical intervention of influenza virus mRNA nuclear export

(2020) Matthew Esparza et al.   PLoS Pathogens

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

(2020) Matthias Thoms et al.   SCIENCE

SARS coronavirus protein nsp1 disrupts localization of Nup93 from the nuclear pore complex

(2019) Garret N. Gomez et al.   Biochemistry and Cell Biology

Structural basis for influenza virus NS1 protein block of mRNA nuclear export

(2019) Ke Zhang et al.   Nature Microbiology

Mechanisms of nuclear mRNA export: A structural perspective

(2019) Yihu Xie et al.   TRAFFIC

Integrative structure and functional anatomy of a nuclear pore complex

(2018) Seung Joong Kim et al.   NATURE

A Nuclear Export Block Triggers the Decay of Newly Synthesized Polyadenylated RNA

(2018) Agnieszka Tudek et al.   Cell Reports

The role of TREX in gene expression and disease

(2016) C. G. Heath et al.   BIOCHEMICAL JOURNAL

Influenza virus mRNA trafficking through host nuclear speckles

(2016) Amir Mor et al.   Nature Microbiology

Control of mammalian gene expression by selective mRNA export

(2015) Vihandha O. Wickramasinghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export

(2012) Liang Zhang et al.   JOURNAL OF CELL BIOLOGY

Severe Acute Respiratory Syndrome Coronavirus Protein nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation

(2012) K. G. Lokugamage et al.   JOURNAL OF VIROLOGY

TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export

(2012) Nicolas Viphakone et al.   Nature Communications

SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

(2011) Cheng Huang et al.   PLoS Pathogens

The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

(2011) Susanne Pfefferle et al.   PLoS Pathogens

Nuclear export of mRNA

(2010) Murray Stewart   TRENDS IN BIOCHEMICAL SCIENCES

mRNA nuclear export at a glance

(2009) S. R. Carmody et al.   JOURNAL OF CELL SCIENCE

A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein

(2009) Wataru Kamitani et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

(2008) K. Narayanan et al.   JOURNAL OF VIROLOGY

Definition of global and transcript-specific mRNA export pathways in metazoans

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