Mechanisms of Coronavirus Nsp1-Mediated Control of Host and Viral Gene Expression

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Another Decade, Another Coronavirus

(2020) Stanley Perlman   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of the COVID-2019 (SARS-CoV-2) pathogenesis with SARS-CoV and MERS-CoV infections

(2020) Mona Fani et al.   Future Virology

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model

(2020) Barry Rockx et al.   SCIENCE

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

(2020) Matthias Thoms et al.   SCIENCE

Structural and Biological Basis of Alphacoronavirus nsp1 Associated with Host Proliferation and Immune Evasion

(2020) Zhou Shen et al.   Viruses-Basel

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

(2020) Abhik K. Banerjee et al.   CELL

Emerging of a SARS-CoV-2 viral strain with a deletion in nsp1

(2020) Francesca Benedetti et al.   Journal of Translational Medicine

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

(2020) Katharina Schubert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evasion of Type I Interferon by SARS-CoV-2

(2020) Hongjie Xia et al.   Cell Reports

β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway

(2020) Sourish Ghosh et al.   CELL

The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translation

(2020) Antonin TIDU et al.   RNA

SARS coronavirus protein nsp1 disrupts localization of Nup93 from the nuclear pore complex

(2019) Garret N. Gomez et al.   Biochemistry and Cell Biology

A conserved region of nonstructural protein 1 from alphacoronaviruses inhibits host gene expression and is critical for viral virulence

(2019) Zhou Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms

(2018) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

Deletion of accessory genes 3a, 3b, 5a or 5b from avian coronavirus infectious bronchitis virus induces an attenuated phenotype both in vitro and in vivo

(2018) Andrea Laconi et al.   JOURNAL OF GENERAL VIROLOGY

The endonucleolytic RNA cleavage function of nsp1 of Middle East respiratory syndrome coronavirus promotes the production of infectious virus particles in specific human cell lines

(2018) Keisuke Nakagawa et al.   JOURNAL OF VIROLOGY

Coxsackievirus A6 Induces Cell Cycle Arrest in G0/G1 Phase for Viral Production

(2018) Zengyan Wang et al.   Frontiers in Cellular and Infection Microbiology

Origin and evolution of pathogenic coronaviruses

(2018) Jie Cui et al.   NATURE REVIEWS MICROBIOLOGY

High Prevalence of MERS-CoV Infection in Camel Workers in Saudi Arabia

(2018) Abeer N. Alshukairi et al.   mBio

Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications

(2017) K.H. Kim et al.   JOURNAL OF HOSPITAL INFECTION

Type III Interferon Restriction by Porcine Epidemic Diarrhea Virus and the Role of Viral Protein nsp1 in IRF1 Signaling

(2017) Qingzhan Zhang et al.   JOURNAL OF VIROLOGY

Structural Basis for the Inhibition of Host Gene Expression by Porcine Epidemic Diarrhea Virus nsp1

(2017) Zhou Shen et al.   JOURNAL OF VIROLOGY

Molecular Evolution of Human Coronavirus Genomes

(2017) Diego Forni et al.   TRENDS IN MICROBIOLOGY

Inhibition of NF-κB activity by the porcine epidemic diarrhea virus nonstructural protein 1 for innate immune evasion

(2017) Qingzhan Zhang et al.   VIROLOGY

MERS coronavirus nsp1 participates in an efficient propagation through a specific interaction with viral RNA

(2017) Yutaka Terada et al.   VIROLOGY

Human Enterovirus 68 Interferes with the Host Cell Cycle to Facilitate Viral Production

(2017) Zeng-yan Wang et al.   Frontiers in Cellular and Infection Microbiology

Infectious Bronchitis Coronavirus Limits Interferon Production by Inducing a Host Shutoff That Requires Accessory Protein 5b

(2016) Joeri Kint et al.   JOURNAL OF VIROLOGY

Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

(2016) Shuo Su et al.   TRENDS IN MICROBIOLOGY

Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1

(2016) Qingzhan Zhang et al.   VIROLOGY

Middle East Respiratory Syndrome Coronavirus nsp1 Inhibits Host Gene Expression by Selectively Targeting mRNAs Transcribed in the Nucleus while Sparing mRNAs of Cytoplasmic Origin

(2015) Kumari G. Lokugamage et al.   JOURNAL OF VIROLOGY

Murine Norovirus Replication Induces G0/G1Cell Cycle Arrest in Asynchronously Growing Cells

(2015) Colin Davies et al.   JOURNAL OF VIROLOGY

Dissection of Amino-Terminal Functional Domains of Murine Coronavirus Nonstructural Protein 3

(2015) Kelley R. Hurst-Hess et al.   JOURNAL OF VIROLOGY

Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression

(2015) Krishna Narayanan et al.   VIRUS RESEARCH

Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine

(2015) Jose M. Jimenez-Guardeño et al.   PLoS Pathogens

Accessory proteins of SARS-CoV and other coronaviruses

(2014) Ding Xiang Liu et al.   ANTIVIRAL RESEARCH

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Attenuation of Mouse Hepatitis Virus by Deletion of the LLRKxGxKG Region of Nsp1

(2013) Lin Lei et al.   PLoS One

Identification of Residues of SARS-CoV nsp1 That Differentially Affect Inhibition of Gene Expression and Antiviral Signaling

(2013) Andrew R. Jauregui et al.   PLoS One

Atlas of coronavirus replicase structure

(2013) Benjamin W. Neuman et al.   VIRUS RESEARCH

Severe Acute Respiratory Syndrome Coronavirus Protein nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation

(2012) K. G. Lokugamage et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp1 Facilitates Efficient Propagation in Cells through a Specific Translational Shutoff of Host mRNA

(2012) T. Tanaka et al.   JOURNAL OF VIROLOGY

A Common Strategy for Host RNA Degradation by Divergent Viruses

(2012) M. M. Gaglia et al.   JOURNAL OF VIROLOGY

Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus

(2012) P. C. Y. Woo et al.   JOURNAL OF VIROLOGY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

(2011) Cheng Huang et al.   PLoS Pathogens

The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

(2011) Susanne Pfefferle et al.   PLoS Pathogens

Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities

(2010) Yongjin Wang et al.   INFECTION GENETICS AND EVOLUTION

Alphacoronavirus Transmissible Gastroenteritis Virus nsp1 Protein Suppresses Protein Translation in Mammalian Cells and in Cell-Free HeLa Cell Extracts but Not in Rabbit Reticulocyte Lysate

(2010) C. Huang et al.   JOURNAL OF VIROLOGY

Bovine Coronavirus Associated Syndromes

(2010) Mélanie J. Boileau et al.   VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE

Coronavirus Genomics and Bioinformatics Analysis

(2010) Patrick C. Y. Woo et al.   Viruses-Basel

Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses

(2009) Y. Tohya et al.   JOURNAL OF VIROLOGY

A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein

(2009) Wataru Kamitani et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

(2008) K. Narayanan et al.   JOURNAL OF VIROLOGY

Complete nucleotide sequence of polyprotein gene 1 and genome organization of turkey coronavirus

(2008) Jianzhong Cao et al.   VIRUS RESEARCH

SARS coronavirus accessory proteins

(2007) Krishna Narayanan et al.   VIRUS RESEARCH