Modeling X-chromosome inactivation and reactivation during human development

Species-specific regulation of XIST by the JPX/FTX orthologs

(2023) Olga Rosspopoff et al.   NUCLEIC ACIDS RESEARCH

Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys

(2023) Sayuri Gyobu‐Motani et al.   EMBO JOURNAL

Origin and segregation of the human germline

(2023) Aracely Castillo-Venzor et al.   Life Science Alliance

Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens

(2022) Rowan M. Karvas et al.   Cell Stem Cell

8C-like cells capture the human zygotic genome activation program in vitro

(2022) Jasmin Taubenschmid-Stowers et al.   Cell Stem Cell

Controlled X‐chromosome dynamics defines meiotic potential of female mouse in vitro germ cells

(2022) Jacqueline Severino et al.   EMBO JOURNAL

Rolling back human pluripotent stem cells to an eight-cell embryo-like stage

(2022) Md. Abdul Mazid et al.   NATURE

Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation

(2022) Banushree Kumar et al.   NATURE CELL BIOLOGY

Preventing erosion of X-chromosome inactivation in human embryonic stem cells

(2022) Marissa Cloutier et al.   Nature Communications

Recapitulating early human development with 8C-like cells

(2022) Xiu Yu et al.   Cell Reports

Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage

(2021) Qifan Zhu et al.   Cell Reports

Human naive epiblast cells possess unrestricted lineage potential

(2021) Ge Guo et al.   Cell Stem Cell

Naive stem cell blastocyst model captures human embryo lineage segregation

(2021) Ayaka Yanagida et al.   Cell Stem Cell

Capturing human trophoblast development with naive pluripotent stem cells in vitro

(2021) Shingo Io et al.   Cell Stem Cell

Blastocyst-like structures generated from human pluripotent stem cells

(2021) Leqian Yu et al.   NATURE

Deletion of lncRNA XACT does not change expression dosage of X-linked genes, but affects differentiation potential in hPSCs

(2021) Nami Motosugi et al.   Cell Reports

Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening

(2021) Shafqat A. Khan et al.   Cell Reports

Human blastoids model blastocyst development and implantation

(2021) Harunobu Kagawa et al.   NATURE

Single-cell transcriptomic characterization of a gastrulating human embryo

(2021) Richard C. V. Tyser et al.   NATURE

The X chromosome dosage compensation program during the development of cynomolgus monkeys

(2021) Ikuhiro Okamoto et al.   SCIENCE

X chromosome inactivation in human development

(2020) Catherine Patrat et al.   DEVELOPMENT

Derivation of trophoblast stem cells from naïve human pluripotent stem cells

(2020) Chen Dong et al.   eLife

Generation of human oogonia from induced pluripotent stem cells in culture

(2020) Chika Yamashiro et al.   Nature Protocols

Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation

(2020) Chenrui An et al.   Cell Stem Cell

Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome

(2020) Jessica K. Cinkornpumin et al.   Stem Cell Reports

Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation

(2020) Tsotne Chitiashvili et al.   NATURE CELL BIOLOGY

Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation

(2019) Maria Rostovskaya et al.   DEVELOPMENT

Global Characterization of X Chromosome Inactivation in Human Pluripotent Stem Cells

(2019) Shiran Bar et al.   Cell Reports

Reconstituting the transcriptome and DNA methylome landscapes of human implantation

(2019) Fan Zhou et al.   NATURE

The eXceptional nature of the X chromosome

(2018) Bradley P Balaton et al.   HUMAN MOLECULAR GENETICS

Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells

(2018) Ábel Vértesy et al.   Nature Communications

Generation of human oogonia from induced pluripotent stem cells in vitro

(2018) Chika Yamashiro et al.   SCIENCE

Regulation of X-chromosome dosage compensation in human: mechanisms and model systems

(2017) Anna Sahakyan et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation

(2017) Sanjeet Patel et al.   Cell Reports

Early X chromosome inactivation during human preimplantation development revealed by single-cell RNA-sequencing

(2017) Joana C. Moreira de Mello et al.   Scientific Reports

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos

(2016) Sophie Petropoulos et al.   CELL

Molecular Criteria for Defining the Naive Human Pluripotent State

(2016) Thorold W. Theunissen et al.   Cell Stem Cell

Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification

(2016) Ferdinand von Meyenn et al.   DEVELOPMENTAL CELL

A developmental coordinate of pluripotency among mice, monkeys and humans

(2016) Tomonori Nakamura et al.   NATURE

Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization

(2016) Kun Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dosage compensation of the sex chromosomes and autosomes

(2016) Christine M. Disteche   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells

(2015) Fan Guo et al.   CELL

DNA Demethylation Dynamics in the Human Prenatal Germline

(2015) Sofia Gkountela et al.   CELL

A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development

(2015) Walfred W.C. Tang et al.   CELL

Erosion of X Chromosome Inactivation in Human Pluripotent Cells Initiates with XACT Coating and Depends on a Specific Heterochromatin Landscape

(2015) Céline Vallot et al.   Cell Stem Cell

Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

(2015) Kotaro Sasaki et al.   Cell Stem Cell

Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

(2014) Yasuhiro Takashima et al.   CELL

Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency

(2014) Thorold W. Theunissen et al.   Cell Stem Cell

Effects of assisted reproductive technologies on human sex ratio at birth

(2014) Walid E. Maalouf et al.   FERTILITY AND STERILITY

Erosion of Dosage Compensation Impacts Human iPSC Disease Modeling

(2012) Shila Mekhoubad et al.   Cell Stem Cell

Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation

(2012) J. W. Mugford et al.   DEVELOPMENT

Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development

(2011) Ikuhiro Okamoto et al.   NATURE

The effect on human sex ratio at birth by assisted reproductive technology (ART) procedures - an assessment of babies born following single embryo transfers, Australia and New Zealand, 2002-2006

(2010) JH Dean et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome Inactivation

(2010) Di Tian et al.   CELL

RNF12 Is an X-Encoded Dose-Dependent Activator of X Chromosome Inactivation

(2009) Iris Jonkers et al.   CELL

Nanog Is the Gateway to the Pluripotent Ground State

(2009) Jose Silva et al.   CELL

X Chromosome Dosage Compensation: How Mammals Keep the Balance

(2008) Bernhard Payer et al.   Annual Review of Genetics

X Chromosome Activity in Mouse XX Primordial Germ Cells

(2008) Susana M. Chuva de Sousa Lopes et al.   PLoS Genetics