RGS10 inhibits proliferation and migration of pulmonary arterial smooth muscle cell in pulmonary hypertension via AKT/mTORC1 signaling

2022 ESC/ERS-Leitlinien zur Diagnostik und Therapie der pulmonalen Hypertonie

(2023) Stephan Rosenkranz   HERZ

Nuclear receptor subfamily 1 group D member 1 suppresses the proliferation, migration of adventitial fibroblasts, and vascular intimal hyperplasia via mammalian target of rapamycin complex 1/β-catenin pathway

(2023) Ke Peng et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Pulmonary artery smooth muscle cell phenotypic switching: A key event in the early stage of pulmonary artery hypertension

(2023) Binghao Ma et al.   DRUG DISCOVERY TODAY

RAS protein activator like 2 promotes the proliferation and migration of pulmonary artery smooth muscle cell through AKT/mammalian target of Rapamycin complex 1 pathway in pulmonary hypertension

(2022) Sheng Hu et al.   Bioengineered

Inhibition of PIKfyve Ameliorates the Proliferation and Migration of Vascular Smooth Muscle Cells and Vascular Intima Hyperplasia By Reducing mTORC1 Activity

(2022) Min Gu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Decrease in Tripartite Motif Containing 24 suppresses hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells via the AKT/mammalian target of rapamycin complex 1 pathway

(2022) Jingwen Xu et al.   Bioengineered

Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT

(2021) Hao Zhou et al.   ONCOLOGY REPORTS

Pulmonary Arterial Hypertension

(2021) Paul M. Hassoun   NEW ENGLAND JOURNAL OF MEDICINE

miR‑199b‑5p mediates adriamycin‑induced podocyte apoptosis by inhibiting the expression of RGS10

(2021) Gaoting Qu et al.   Experimental and Therapeutic Medicine

RGS10 Reduces Lethal Influenza Infection and Associated Lung Inflammation in Mice

(2021) Faris Almutairi et al.   Frontiers in Immunology

NF2 deficiency accelerates neointima hyperplasia following vascular injury via promoting YAP-TEAD1 interaction in vascular smooth muscle cells

(2020) Xiongshan Sun et al.   Aging-US

A Global Map of G Protein Signaling Regulation by RGS Proteins

(2020) Ikuo Masuho et al.   CELL

Low dose 100 cGy irradiation as a potential therapy for pulmonary hypertension

(2019) Pamela C. Egan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Wild-type p53-induced phosphatase 1 promotes vascular smooth muscle cell proliferation and neointima hyperplasia after vascular injury via p-adenosine 5′-monophosphate-activated protein kinase/mammalian target of rapamycin complex 1 pathway

(2019) Xiongshan Sun et al.   JOURNAL OF HYPERTENSION

Role of polypyrimidine tract-binding protein 1/yin yang 2 signaling in regulating vascular smooth muscle cell proliferation and neointima hyperplasia

(2019) Zhen Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Therapeutic Options for In-Stent Restenosis

(2018) Charles Nicolais et al.   Current Cardiology Reports

Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS/NFκB/mTOR/P70S6K signaling cascade

(2018) Qing-Bo Lu et al.   Redox Biology

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Selective Tuberous Sclerosis Complex 1 Gene Deletion in Smooth Muscle Activates Mammalian Target of Rapamycin Signaling and Induces Pulmonary Hypertension

(2016) Amal Houssaini et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis

(2016) Jae-Kyung Lee et al.   Journal of Neuroinflammation

RGS10 Negatively Regulates Platelet Activation and Thrombogenesis

(2016) Nicole R. Hensch et al.   PLoS One

Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells

(2015) Molly K. Altman et al.   CANCER LETTERS

mTORC1 Is Involved in Hypoxia-Induced Pulmonary Hypertension Through the Activation of Notch3

(2014) Wang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone Destruction

(2014) Sen Yang et al.   Bone Research

Rapamycin Reverses Pulmonary Artery Smooth Muscle Cell Proliferation in Pulmonary Hypertension

(2013) Amal Houssaini et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

A Novel Murine Model of Severe Pulmonary Arterial Hypertension

(2011) Loredana Ciuclan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulator of G-Protein Signaling-10 Negatively Regulates NF- B in Microglia and Neuroprotects Dopaminergic Neurons in Hemiparkinsonian Rats

(2011) J.-K. Lee et al.   JOURNAL OF NEUROSCIENCE