RAS protein activator like 2 promotes the proliferation and migration of pulmonary artery smooth muscle cell through AKT/mammalian target of Rapamycin complex 1 pathway in pulmonary hypertension

mTOR Signaling in Pulmonary Vascular Disease: Pathogenic Role and Therapeutic Target

(2021) Aleksandra Babicheva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of AMPK inhibits Galectin-3-induced pulmonary artery smooth muscle cells proliferation by upregulating hippo signaling effector YAP

(2021) Qianqian Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Luteolin Ameliorates Experimental Pulmonary Arterial Hypertension via Suppressing Hippo-YAP/PI3K/AKT Signaling Pathway

(2021) Wanyun Zuo et al.   Frontiers in Pharmacology

Tregs-derived interleukin 35 attenuates endothelial proliferation through STAT1 in pulmonary hypertension

(2021) Naifu Wan et al.   Annals of Translational Medicine

Blockade of JAK2 protects mice against hypoxia‐induced pulmonary arterial hypertension by repressing pulmonary arterial smooth muscle cell proliferation

(2020) Lei Zhang et al.   CELL PROLIFERATION

Effects of neuromuscular electrical stimulation in patients with pulmonary arterial hypertension: a randomized controlled pilot study

(2020) Buse Ozcan Kahraman et al.   Journal of Cardiology

The role of metabolic checkpoint regulators in B cell survival and transformation

(2020) Julia Jellusova   IMMUNOLOGICAL REVIEWS

Wild-type p53-induced phosphatase 1 promotes vascular smooth muscle cell proliferation and neointima hyperplasia after vascular injury via p-adenosine 5′-monophosphate-activated protein kinase/mammalian target of rapamycin complex 1 pathway

(2019) Xiongshan Sun et al.   JOURNAL OF HYPERTENSION

Crosstalk between the Akt/mTORC1 and NF-κB signaling pathways promotes hypoxia-induced pulmonary hypertension by increasing DPP4 expression in PASMCs

(2019) Ying Li et al.   ACTA PHARMACOLOGICA SINICA

Smooth muscle cell–specific fibronectin-EDA mediates phenotypic switching and neointimal hyperplasia

(2019) Manish Jain et al.   JOURNAL OF CLINICAL INVESTIGATION

RASAL2 Plays Inconsistent Roles in Different Cancers

(2019) Bolun Zhou et al.   Frontiers in Oncology

RASAL2 promotes tumor progression through LATS2/YAP1 axis of hippo signaling pathway in colorectal cancer

(2018) Yi Pan et al.   Molecular Cancer

The expression and function of RASAL2 in renal cell carcinoma angiogenesis

(2018) Ke Hui et al.   Cell Death & Disease

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer

(2018) Jingyi Liu et al.   Nature Communications

Upregulation of RASAL2 promotes proliferation and metastasis, and is targeted by miR-203 in hepatocellular carcinoma

(2017) Jian-Feng Fang et al.   Molecular Medicine Reports

Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders

(2017) Xiaoqiang Zhu et al.   Molecular Metabolism

Up-regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension

(2016) Reza Aghamohammadzadeh et al.   FASEB JOURNAL

Combination therapy versus monotherapy for pulmonary arterial hypertension: a meta-analysis

(2016) Annie Christine Lajoie et al.   Lancet Respiratory Medicine

Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension

(2015) Haiyang Tang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Adiponectin affects vascular smooth muscle cell proliferation and apoptosis through modulation of the mitofusin-2-mediated Ras-Raf-Erk1/2 signaling pathway

(2015) WENBO ZHANG et al.   Molecular Medicine Reports

Where is mTOR and what is it doing there?

(2014) Charles Betz et al.   JOURNAL OF CELL BIOLOGY

RASAL2 activates RAC1 to promote triple-negative breast cancer progression

(2014) Min Feng et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFβ-TAK1-MAPK pathways in PAH

(2012) Md Talat Nasim et al.   HUMAN MOLECULAR GENETICS

A Novel Murine Model of Severe Pulmonary Arterial Hypertension

(2011) Loredana Ciuclan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia

(2011) Vera P. Krymskaya et al.   FASEB JOURNAL

Mechanisms of disease: pulmonary arterial hypertension

(2011) Ralph T. Schermuly et al.   Nature Reviews Cardiology

Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era

(2010) Marc Humbert et al.   CIRCULATION

The roles of MAPKs in disease

(2008) Michael C Lawrence et al.   CELL RESEARCH