The anti-Aspergillusdrug pipeline: Is the glass half full or empty?: Table 1.

“Is there an emerging need for new antifungals?”

(2016) John R. Perfect   EXPERT OPINION ON EMERGING DRUGS

T-2307, a novel arylamidine, is transported intoCandida albicansby a high-affinity spermine and spermidine carrier regulated by Agp2

(2016) Hiroshi Nishikawa et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Identification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis

(2016) Dafna Ben Yaakov et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Novel Water-Soluble Amphotericin B-PEG Conjugates with Low Toxicity and Potent in Vivo Efficacy

(2016) Assaf Halperin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biofilm Filtrates of Pseudomonas aeruginosa Strains Isolated from Cystic Fibrosis Patients Inhibit Preformed Aspergillus fumigatus Biofilms via Apoptosis

(2016) Fazal Shirazi et al.   PLoS One

ImmunoPET/MR imaging allows specific detection ofAspergillus fumigatuslung infection in vivo

(2016) Anna-Maria Rolle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hitting the Caspofungin Salvage Pathway of Human-Pathogenic Fungi with the Novel Lasso Peptide Humidimycin (MDN-0010)

(2015) Vito Valiante et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components

(2015) Shriya Raj et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification and Characterization of a Novel Family of Selective Antifungal Compounds (CANBEFs) That Interfere with Fungal Protein Synthesis

(2015) Gabriel Mircus et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroActivity of ASP2397 against Aspergillus Isolates with or without Acquired Azole Resistance Mechanisms

(2015) Maiken Cavling Arendrup et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Immunotherapy of Fungal Infections

(2015) Kausik Datta et al.   IMMUNOLOGICAL INVESTIGATIONS

Nebulised amphotericin B-polymethacrylic acid nanoparticle prophylaxis prevents invasive aspergillosis

(2015) Khojasteh Shirkhani et al.   Nanomedicine-Nanotechnology Biology and Medicine

Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide

(2015) Kyaw Zaw Hein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

(2015) Visesato Mor et al.   mBio

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens

(2015) Nicole Robbins et al.   Cell Reports

Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis

(2015) Frédéric Lamoth et al.   Frontiers in Microbiology

Identification of a Key Lysine Residue in Heat Shock Protein 90 Required for Azole and Echinocandin Resistance in Aspergillus fumigatus

(2014) Frédéric Lamoth et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activity, Reduced Toxicity, and Scale-Up Synthesis of Amphotericin B-Conjugated Polysaccharide

(2014) Diana E. Ickowicz et al.   BIOMACROMOLECULES

Antifungal drug discovery: the process and outcomes

(2014) Richard Calderone et al.   Future Microbiology

Granulocyte Transfusion Combined with Granulocyte Colony Stimulating Factor in Severe Infection Patients with Severe Aplastic Anemia: A Single Center Experience from China

(2014) Huaquan Wang et al.   PLoS One

Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

(2014) P. R. Kumaresan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antifungal Drug Development: Challenges, Unmet Clinical Needs, and New Approaches

(2014) T. Roemer et al.   Cold Spring Harbor Perspectives in Medicine

In Vitro Activity of Calcineurin and Heat Shock Protein 90 Inhibitors against Aspergillus fumigatus Azole- and Echinocandin-Resistant Strains

(2012) F. Lamoth et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

T-2307 Causes Collapse of Mitochondrial Membrane Potential in Yeast

(2012) Tatsuya Shibata et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reversible skeletal disease and high fluoride serum levels in hematologic patients receiving voriconazole

(2012) B. Gerber et al.   BLOOD

Immunotherapy for fungal infections

(2012) Darius Armstrong-James et al.   CURRENT OPINION IN MICROBIOLOGY

Tacrolimus Enhances the Potency of Posaconazole Against Rhizopus oryzae In Vitro and in an Experimental Model of Mucormycosis

(2012) R. E. Lewis et al.   JOURNAL OF INFECTIOUS DISEASES

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

In VitroActivity of a Novel Broad-Spectrum Antifungal, E1210, Tested against Aspergillus spp. Determined by CLSI and EUCAST Broth Microdilution Methods

(2011) Michael A. Pfaller et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy of Oral E1210, a New Broad-Spectrum Antifungal with a Novel Mechanism of Action, in Murine Models of Candidiasis, Aspergillosis, and Fusariosis

(2011) Katsura Hata et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroActivity of E1210, a Novel Antifungal, against Clinically Important Yeasts and Molds

(2011) Mamiko Miyazaki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

E1210, a New Broad-Spectrum Antifungal, Suppresses Candida albicans Hyphal Growth through Inhibition of Glycosylphosphatidylinositol Biosynthesis

(2011) Nao-aki Watanabe et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Confronting the Challenges of Natural Product-Based Antifungal Discovery

(2011) Terry Roemer et al.   CHEMISTRY & BIOLOGY

In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Candida spp. as determined by CLSI broth microdilution method

(2011) Michael A. Pfaller et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Pre-clinical development of antifungal susceptibility test methods for the testing of the novel antifungal agent E1210 versus Candida: comparison of CLSI and European Committee on Antimicrobial Susceptibility Testing methods

(2011) M. A. Pfaller et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Uptake of T-2307, a novel arylamidine, in Candida albicans

(2010) H. Nishikawa et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Activity of MGCD290, a Hos2 Histone Deacetylase Inhibitor, in Combination with Azole Antifungals against Opportunistic Fungal Pathogens

(2009) M. A. Pfaller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Granulocyte Transfusions in Children and Young Adults

(2009) Markus G. Seidel et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

In Vitro and In Vivo Antifungal Activities of T-2307, a Novel Arylamidine

(2008) J. Mitsuyama et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Amphotericin B Formulations and Drug Targeting

(2007) J.J. Torrado et al.   JOURNAL OF PHARMACEUTICAL SCIENCES