Article
Physiology
Sebastian L. Johnston, David L. Goldblatt, Scott E. Evans, Michael J. Tuvim, Burton F. Dickey
Summary: Airway epithelial cells sense and respond defensively to pathogens, with specificity for different pathogen classes. Type 1 immune responses target intracellular pathogens like viruses, while Type 2 responses target helminths and fungi, and Type 3 responses target extracellular microbial pathogens. These responses involve changes in gene expression, release of cytokines, and induction of immune responses to resist infection.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Dermatology
Aleksandra Batycka-Baran, Wojciech Baran, Danuta Nowicka-Suszko, Maria Koziol-Galczynska, Andrzej Bieniek, Lukasz Matusiak, Lukasz Laczmanski, Jacek Cezary Szepietowski
Summary: The study found an increased expression of S100A7 in lesional HS skin compared to perilesional HS skin (p=0.0017). The expression of S100A7 in lesional HS skin was positively associated with serum C-reactive protein concentration and disease severity according to Hurley staging. Serum concentration of S100A7 in individuals with HS was decreased compared to healthy controls and patients with psoriasis.
Review
Immunology
Thomas Plante-Bordeneuve, Charles Pilette, Antoine Froidure
Summary: The interaction between lung epithelium and the immune system plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Pathways such as DAMPs-PAMPs are highlighted as potential mechanisms involved in disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xiaorong Chen, Honghai Zhang, Xueer Wang, Zhugui Shao, Yanqi Li, Guimin Zhao, Feng Liu, Bingyu Liu, Yi Zheng, Tian Chen, Hui Zheng, Lei Zhang, Chengjiang Gao
Summary: This study identifies ovarian tumor deubiquitinase 1 (OTUD1) as an essential regulator of CARD9, which can activate the canonical NF-kappa B and MAPK pathway by deubiquitinating CARD9, impacting immune response following fungal stimulation.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Seika Hashimoto-Hill, Luisa Colapietro, Vivienne Woo, Simona Antonacci, Jordan Whitt, Laura Engleman, Theresa Alenghat
Summary: This study demonstrates that consuming rice bran can reduce the risk of intestinal infection, and the phytate component in it plays a role by promoting innate immune response in intestinal epithelial cells. This effect is dependent on the metabolism of phytate by commensal bacteria.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Food Science & Technology
Ivana Mirkov, Aleksandra Popov Aleksandrov, Marina Ninkov, Dina Tucovic, Jelena Kulas, Milica Zeljkovic, Dusanka Popovic, Milena Kataranovski
Summary: Cadmium is considered one of the most toxic substances affecting various tissues/organs, including the immune system. Studies on Cd's effects on the immune system show inconsistent data in humans and animals due to different exposure levels and experimental systems. However, Cd is known to influence immune cells and responses, although the exact mechanisms are still unclear. In summary, Cd-induced immune alterations may weaken defenses against pathogens and tissue repair activities, highlighting it as a significant health hazard.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemical Research Methods
Reese A. Martin, Ann T. Tate
Summary: Genes involved in immune defense resist rapidly evolving parasites and pathogens and are highly represented in the immune system. Pleiotropic signaling genes affect multiple phenotypes and may play a role in the evolution of inducible immunity. Pleiotropy is prevalent in immune signaling networks, and it provides an advantage for host fitness during infection.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soyoon Sim, Dong-Hyun Lee, Kwang-sun Kim, Hyeon Ju Park, Yoon-Keun Kim, Youngwoo Choi, Hae-Sim Park
Summary: Bacterial extracellular vesicles (EVs) from Micrococcus luteus have been found to regulate airway inflammation and improve lung function in asthma patients. These EVs specifically increase the levels of IgG4 and miRNA expression, which inhibit neutrophilic inflammation and improve respiratory symptoms. Therefore, MlEVs could be a potential novel therapeutic agent for managing neutrophilic asthma.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Ernest Y. Lee, Liana C. Chan, Huiyuan Wang, Juelline Lieng, Mandy Hung, Yashes Srinivasan, Jennifer Wang, James A. Waschek, Andrew L. Ferguson, Kuo-Fen Lee, Nannette Y. Yount, Michael R. Yeaman, Gerard C. L. Wong
Summary: This study confirms the antimicrobial role of PACAP and reveals its selective induction in the brain during infection. Through various mechanisms, including disruption of pathogen membrane integrity and activation of cell death pathways, PACAP exhibits antimicrobial activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Dennis K. Ninaber, Anne M. van der Does, Pieter S. Hiemstra
Summary: The airway epithelial cell layer is constantly exposed to inhaled substances and plays a central role in lung diseases. In vitro epithelial culture models offer a controlled environment for studying the role of epithelium in pathogenesis and therapy. This manuscript provides a robust protocol for isolating and culturing airway epithelial cells, along with characterization and various applications of these cultures.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Review
Immunology
Kellen J. Cavagnero, Richard L. Gallo
Summary: Fibroblasts are stromal cells that produce extracellular matrix and play a role in tissue structure and scar formation. Recent studies have found that they are highly heterogeneous and actively participate in both innate and adaptive immune defense. Detailed analysis of barrier tissues such as skin, gut, and lung shows that some fibroblasts directly sense pathogens and other danger signals, contributing to host defense functions such as antimicrobial activity, white blood cell recruitment, and production of cytokines relevant to inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Prashanta Silwal, In Soo Kim, Eun-Kyeong Jo
Summary: Autophagy plays a crucial role in enhancing the immune responses and controlling inflammation against NTM infections, and holds potential as a therapeutic target for combating NTM infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Miroslav Dinic, Stefan Jakovljevic, Jelena Dokic, Nikola Popovic, Dusan Radojevic, Ivana Strahinic, Natasa Golic
Summary: The host-microbiota cross-talk plays a crucial role in innate immune response and host resistance during infection. Probiotic strain Lactobacillus curvatus BGMK2-41 was shown to stimulate immune response and resistance in Caenorhabditis elegans against Staphylococcus aureus and Pseudomonas aeruginosa by activating the PMK-1/p38 MAPK immunity pathway. The study suggests that PMK-1/p38 MAPK-dependent immune regulation by BGMK2-41 is essential for probiotic-mediated C. elegans protection against gram-positive and gram-negative bacteria.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Sara Bodahl, Samuel Cerps, Lena Uller, Bengt-Olof Nilsson
Summary: LL-37 enhances poly I:C-induced expression of TLR3 mRNA and protein, possibly through enhanced import of poly I:C. Dexamethasone reduces LL-37/poly I:C-induced TLR3 expression by attenuating NF-kappa B activity.
Article
Biochemistry & Molecular Biology
Xiaoyan Wang, Jing Xiong, Diwei Zhou, Shanfeng Zhang, Li Wang, Qingqing Tian, Changming Li, Jie Liu, Yaping Wu, Junying Li, Jun Wang
Summary: This study uncovered the role of TRIM34 in regulating IAV-induced programmed cell death by mediating the K63-linked polyubiquitination of ZBP1. The interaction between TRIM34 and ZBP1 protected mice from inflammatory responses and epithelial damage during IAV infection. Higher levels of ZBP1 were found to correlate with increased proinflammatory cytokines in IAV-infected patients.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
P. Schaepe, M. J. Kwon, B. Baumann, B. Gutschmann, S. Jung, S. Lenz, B. Nitsche, N. Paege, T. Schuetze, T. C. Cairns, V Meyer
NUCLEIC ACIDS RESEARCH
(2019)
Article
Multidisciplinary Sciences
Xia Da, Yayoi Nishiyama, Duerna Tie, Kyaw Zaw Hein, Osamu Yamamoto, Eishin Morita
SCIENTIFIC REPORTS
(2019)
Review
Gastroenterology & Hepatology
Bjoern O. Schroeder
GASTROENTEROLOGY REPORT
(2019)
Article
Immunology
Joana K. Volk, Elisabeth E. L. Nystrom, Sjoerd van der Post, Beatriz M. Abad, Bjoern O. Schroeder, Asa Johansson, Frida Svensson, Sofia Javerfelt, Malin E. V. Johansson, Gunnar C. Hansson, George M. H. Birchenough
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Review
Chemistry, Medicinal
Renato Bruno, Marc Maresca, Stephane Canaan, Jean-Francois Cavalier, Kamel Mabrouk, Celine Boidin-Wichlacz, Hamza Olleik, Daniela Zeppilli, Priscille Brodin, Francois Massol, Didier Jollivet, Sascha Jung, Aurelie Tasiemski
Review
Gastroenterology & Hepatology
Eduard F. Stange, Bjoern O. Schroeder
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2019)
Article
Multidisciplinary Sciences
Susanne Keipert, Dominik Lutter, Bjoern O. Schroeder, Daniel Brandt, Marcus Stahlman, Thomas Schwarzmayr, Elisabeth Graf, Helmut Fuchs, Martin Hrabe de Angelis, Matthias H. Tschoep, Jan Rozman, Martin Jastroch
NATURE COMMUNICATIONS
(2020)
Article
Microbiology
Norman Paege, Dirk Warnecke, Simone Zaeuner, Silke Hagen, Ana Rodrigues, Birgit Baumann, Melanie Thiess, Sascha Jung, Vera Meyer
Review
Immunology
Fabiola Puertolas-Balint, Bjoern O. Schroeder
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Bjorn O. Schroder, George M. H. Birchenough, Meenakshi Pradhan, Elisabeth E. L. Nystrom, Marcus Henricsson, Gunnar C. Hansson, Fredrik Backhed
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Microbiology
Maria Naama, Shahar Telpaz, Aya Awad, Shira Ben-Simon, Sarina Harshuk-Shabso, Sonia Modilevsky, Elad Rubin, Jasmin Sawaed, Lilach Zelik, Mor Zigdon, Nofar Asulin, Sondra Turjeman, Michal Werbner, Supapit Wongkuna, Rachel Feeney, Bjoern O. Schroeder, Abraham Nyska, Meital Nuriel-Ohayon, Shai Bel
Summary: Colonic goblet cells secrete mucus to protect against bacterial invasion and inflammation. Activation of autophagy in mice via Beclin 1 reduces endoplasmic reticulum (ER) stress, leading to thicker and less penetrable mucus production. This ER-stress-mediated regulation of mucus secretion is dependent on the microbiota and the Nod2 gene, and it plays a critical role in maintaining intestinal homeostasis.
CELL HOST & MICROBE
(2023)
Article
Cell Biology
George M. H. Birchenough, Bjoern O. Schroeder, Sinan Sharba, Liisa Arike, Christian V. Recktenwald, Fabiola Puertolas-Balint, Mahadevan V. Subramani, Karl T. Hansson, Bahtiyar Yilmaz, Sara K. Linden, Fredrik Backhed, Gunnar C. Hansson
Summary: Intestinal mucus barriers are important for preventing microbial infections but can be disrupted by a Western-style diet, leading to susceptibility to pathogen colonization.
Article
Microbiology
Fabiola Puertolas-Balint, Bjoern O. O. Schroeder
Summary: Diet has a stronger impact on shaping the gut microbial community composition than defensins. However, defensins can modulate specific microbial taxa and protect the host from diet-induced metabolic dysfunction.
MICROBIOLOGY SPECTRUM
(2023)
Article
Gastroenterology & Hepatology
George Birchenough, Bjoern O. Schroeder, Fredrik Backhed, Gunnar C. Hansson
Article
Multidisciplinary Sciences
Judith Wendler, Bjoern O. Schroeder, Dirk Ehmann, Louis Koeninger, Daniela Mailaender-Sanchez, Christina Lemberg, Stephanie Wanner, Martin Schaller, Eduard F. Stange, Nisar P. Malek, Christopher Weidenmaier, Salome LeibundGut-Landmann, Jan Wehkamp
SCIENTIFIC REPORTS
(2019)