Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication

Efficacy of nirsevimab against respiratory syncytial virus lower respiratory tract infections in preterm and term infants, and pharmacokinetic extrapolation to infants with congenital heart disease and chronic lung disease: a pooled analysis of randomised controlled trials

(2023) Eric A F Simões et al.   Lancet Child & Adolescent Health

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(2023) Akshita Soni et al.   INDIAN JOURNAL OF PEDIATRICS

The effect of influenza virus on the metabolism of peripheral blood mononuclear cells with a metabolomics approach

(2022) Zeinab Karimi et al.   JOURNAL OF MEDICAL VIROLOGY

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis

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Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants

(2022) Laura L. Hammitt et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging Viruses

(2022) Yucheng Zheng et al.   Viruses-Basel

Mortality Associated With Influenza and Respiratory Syncytial Virus in the US, 1999-2018

(2022) Chelsea L. Hansen et al.   JAMA Network Open

Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication

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Ribavirin for Treatment of Subjects with Respiratory Syncytial Virus-Related Infection: A Systematic Review and Meta-Analysis

(2022) Sofia Tejada et al.   ADVANCES IN THERAPY

Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral Chemotherapy

(2022) Claudia Soledad Sepúlveda et al.   Microorganisms

The Novel hDHODH Inhibitor MEDS433 Prevents Influenza Virus Replication by Blocking Pyrimidine Biosynthesis

(2022) Giulia Sibille et al.   Viruses-Basel

Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication

(2021) Anna Luganini et al.   ANTIVIRAL RESEARCH

Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety

(2021) Stefano Sainas et al.   JOURNAL OF MEDICINAL CHEMISTRY

The New Generation hDHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human Coronaviruses

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The pathway to pyrimidines: The essential focus on dihydroorotate dehydrogenase, the mitochondrial enzyme coupled to the respiratory chain

(2020) Monika Löffler et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Metabolic changes during respiratory syncytial virus infection of epithelial cells

(2020) María Martín-Vicente et al.   PLoS One

Dihydroorotate Dehydrogenase Inhibitors in SARS‐CoV‐2 Infection

(2020) Ana R. Coelho et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Re-evaluation of Brequinar sodium, a dihydroorotate dehydrogenase inhibitor

(2019) Godefridus J. Peters   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors

(2019) Yiqing Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

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(2019) Hannah H Nam et al.   BMJ-British Medical Journal

Dihydroorotate dehydrogenase inhibitors in anti-infective drug research

(2019) Donatella Boschi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A guide to polarized airway epithelial models for studies of host-pathogen interactions

(2018) Shakir Hasan et al.   FEBS Journal

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

(2018) Stefano Sainas et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Non-Hospitable Host: Targeting Cellular Factors as an Antiviral Strategy for Respiratory Viruses

(2018) Luciano Amarelle et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses

(2018) Priya Luthra et al.   ANTIVIRAL RESEARCH

Interferon-induced Transmembrane Protein 1 restricts replication of virus that enter cells via the plasma membrane.

(2018) S. E. Smith et al.   JOURNAL OF VIROLOGY

Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response

(2017) Nam Nam Cheung et al.   JOURNAL OF GENERAL VIROLOGY

The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family

(2017) Hideo Negishi et al.   Cold Spring Harbor Perspectives in Biology

Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors

(2016) Clément Grandin et al.   ANTIVIRAL RESEARCH

Current practices for treatment of respiratory syncytial virus and other non-influenza respiratory viruses in high-risk patient populations: a survey of institutions in the Midwestern Respiratory Virus Collaborative

(2016) O.E. Beaird et al.   Transplant Infectious Disease

A Simple Screening Approach To Prioritize Genes for Functional Analysis Identifies a Role for Interferon Regulatory Factor 7 in the Control of Respiratory Syncytial Virus Disease

(2016) Jacqueline U. McDonald et al.   mSystems

Respiratory syncytial virus, an ongoing medical dilemma: an expert commentary on respiratory syncytial virus prophylactic and therapeutic pharmaceuticals currently in clinical trials

(2015) Lindsay Broadbent et al.   Influenza and Other Respiratory Viruses

Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth through Innate Immunity

(2013) Marianne Lucas-Hourani et al.   PLoS Pathogens

Inhibition of respiratory syncytial virus in vitro and in vivo by the immunosuppressive agent leflunomide

(2011) Melinda C Cox Dunn et al.   ANTIVIRAL THERAPY

Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis

(2011) Q.-Y. Wang et al.   JOURNAL OF VIROLOGY

Phosphorothioate-Modified Oligodeoxynucleotides Inhibit Human Cytomegalovirus Replication by Blocking Virus Entry

(2008) A. Luganini et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

(2008) Joshua Munger et al.   NATURE BIOTECHNOLOGY