The New Generation hDHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human Coronaviruses

COVID-19 vaccines: where we stand and challenges ahead

(2021) Guido Forni et al.   CELL DEATH AND DIFFERENTIATION

Pseudo-Dipeptide Bearing α,α-Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity against Coronaviruses

(2021) Andrea Citarella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Synergism between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloid Leukemia

(2021) Valentina Gaidano et al.   Cancers

Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication

(2021) Anna Luganini et al.   ANTIVIRAL RESEARCH

An update review of emerging small-molecule therapeutic options for COVID-19

(2021) Dengke Tian et al.   BIOMEDICINE & PHARMACOTHERAPY

Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety

(2021) Stefano Sainas et al.   JOURNAL OF MEDICINAL CHEMISTRY

High SARS-CoV-2 Viral Load in Urine Sediment Correlates with Acute Kidney Injury and Poor COVID-19 Outcome

(2021) Paulo Caceres et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

(2020) Victor M Corman et al.   Eurosurveillance

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

(2020) Guangdi Li et al.   NATURE REVIEWS DRUG DISCOVERY

The pathway to pyrimidines: The essential focus on dihydroorotate dehydrogenase, the mitochondrial enzyme coupled to the respiratory chain

(2020) Monika Löffler et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

and Animal Models for SARS-CoV-2 research

(2020) Kazuo Takayama   TRENDS IN PHARMACOLOGICAL SCIENCES

Acute kidney injury in critically ill patients with COVID-19

(2020) Paul Gabarre et al.   INTENSIVE CARE MEDICINE

Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase

(2020) Yechun Xu et al.   Protein & Cell

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

(2020) Rui Xiong et al.   Protein & Cell

SARS-CoV-2 renal tropism associates with acute kidney injury

(2020) Fabian Braun et al.   LANCET

Characteristics of SARS-CoV-2 and COVID-19

(2020) Ben Hu et al.   NATURE REVIEWS MICROBIOLOGY

Covid‐19 and kidney injury: Pathophysiology and molecular mechanisms

(2020) Elham Ahmadian et al.   REVIEWS IN MEDICAL VIROLOGY

Antiviral Drug Discovery To Address the COVID-19 Pandemic

(2020) Douglas D. Richman   mBio

The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines

(2020) Jeremy Luban et al.   VIRUS RESEARCH

IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro

(2020) Friedrich Hahn et al.   Viruses-Basel

One year update on the COVID-19 pandemic: Where are we now?

(2020) Sanjay Kumar Mishra et al.   ACTA TROPICA

Re-evaluation of Brequinar sodium, a dihydroorotate dehydrogenase inhibitor

(2019) Godefridus J. Peters   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells

(2019) Elena Garreta et al.   NATURE MATERIALS

Broad-spectrum coronavirus antiviral drug discovery

(2019) Allison L. Totura et al.   Expert Opinion on Drug Discovery

Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors

(2019) Yiqing Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Broad-Spectrum Antiviral Agents: A Crucial Pandemic Tool

(2019) Amesh Adalja et al.   Expert Review of Anti-Infective Therapy

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

(2019) Ariane J. Brown et al.   ANTIVIRAL RESEARCH

Dihydroorotate dehydrogenase inhibitors in anti-infective drug research

(2019) Donatella Boschi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

(2018) Stefano Sainas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors

(2016) Clément Grandin et al.   ANTIVIRAL RESEARCH

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

(2016) Richard M Deans et al.   Nature Chemical Biology

Coronaviruses — drug discovery and therapeutic options

(2016) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis

(2011) Q.-Y. Wang et al.   JOURNAL OF VIROLOGY