Recapitulation of Perturbed Striatal Gene Expression Dynamics of Donor’s Brains With Ventral Forebrain Organoids Derived From the Same Individuals With Schizophrenia

Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance

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Mapping genomic loci implicates genes and synaptic biology in schizophrenia

(2022) Vassily Trubetskoy et al.   NATURE

Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes

(2022) Kynon J. M. Benjamin et al.   NATURE NEUROSCIENCE

Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases

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Long-term maturation of human cortical organoids matches key early postnatal transitions

(2021) Aaron Gordon et al.   NATURE NEUROSCIENCE

The coding and long noncoding single-cell atlas of the developing human fetal striatum

(2021) Vittoria Dickinson Bocchi et al.   SCIENCE

Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism

(2021) Jorge Urresti et al.   MOLECULAR PSYCHIATRY

Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder

(2021) Job O. de Jong et al.   Nature Communications

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia

(2021) Marja Koskuvi et al.   GLIA

Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids

(2021) Michael Notaras et al.   MOLECULAR PSYCHIATRY

Interneuron origin and molecular diversity in the human fetal brain

(2021) Yuan Yu et al.   NATURE NEUROSCIENCE

Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neurons

(2021) Michihiro Toritsuka et al.   NEUROCHEMISTRY INTERNATIONAL

The iPSC perspective on schizophrenia

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The proteomic architecture of schizophrenia iPSC-derived cerebral organoids reveals alterations in GWAS and neuronal development factors

(2021) Michael Notaras et al.   Translational Psychiatry

Cerebral organoid and mouse models reveal a RAB39b–PI3K–mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes

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Cell stress in cortical organoids impairs molecular subtype specification

(2020) Aparna Bhaduri et al.   NATURE

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression

(2020) Anna S. E. Cuomo et al.   Nature Communications

Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids

(2020) Tomoyo Sawada et al.   MOLECULAR PSYCHIATRY

Generalizing RNA velocity to transient cell states through dynamical modeling

(2020) Volker Bergen et al.   NATURE BIOTECHNOLOGY

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(2020) Shing Wan Choi et al.   Nature Protocols

Generation of four postmortem dura-derived iPS cell lines from four control individuals with genotypic and brain-region-specific transcriptomic data available through the BrainSEQ consortium.

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Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells

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Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms

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Genome-Scale Transcriptional Regulatory Network Models of Psychiatric and Neurodegenerative Disorders

(2019) Jocelynn R. Pearl et al.   Cell Systems

Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders

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Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia

(2019) Leonardo Collado-Torres et al.   NEURON

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development

(2019) Cleber A. Trujillo et al.   Cell Stem Cell

Organoid single-cell genomic atlas uncovers human-specific features of brain development

(2019) Sabina Kanton et al.   NATURE

Convergence of placenta biology and genetic risk for schizophrenia

(2018) Gianluca Ursini et al.   NATURE MEDICINE

Downregulation of ribosome biogenesis during early forebrain development

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(2018) Gioele La Manno et al.   NATURE

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

(2018) Michael J. Gandal et al.   SCIENCE

The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders

(2018) Chao Chen et al.   Science Translational Medicine

Expression-based drug screening of neural progenitor cells from individuals with schizophrenia

(2018) Benjamin Readhead et al.   Nature Communications

Common genetic variation drives molecular heterogeneity in human iPSCs

(2017) Helena Kilpinen et al.   NATURE

Molecular and functional variation in iPSC-derived sensory neurons

(2017) Jeremy Schwartzentruber et al.   NATURE GENETICS

Genetic insights into the neurodevelopmental origins of schizophrenia

(2017) Rebecca Birnbaum et al.   NATURE REVIEWS NEUROSCIENCE

Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine

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Widespread Translational Remodeling during Human Neuronal Differentiation

(2017) John D. Blair et al.   Cell Reports

Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia

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Altering the course of schizophrenia: progress and perspectives

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Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

(2015) Andrew E Jaffe et al.   NATURE NEUROSCIENCE

BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders

(2015) Christian R. Schubert et al.   NEURON

Schizophrenia

(2015) René S. Kahn et al.   Nature Reviews Disease Primers

Prenatal Expression Patterns of Genes Associated With Neuropsychiatric Disorders

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Biological insights from 108 schizophrenia-associated genetic loci

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Developmental regulation of human cortex transcription and its clinical relevance at single base resolution

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Generation of cerebral organoids from human pluripotent stem cells

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Genetic Background Drives Transcriptional Variation in Human Induced Pluripotent Stem Cells

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Genome-wide expression profiling of schizophrenia using a large combined cohort

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Use of Postmortem Human Dura Mater and Scalp for Deriving Human Fibroblast Cultures

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A more efficient method to generate integration-free human iPS cells

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Functional resting-state networks are differentially affected in schizophrenia

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Basal Ganglia Disorders Associated with Imbalances in the Striatal Striosome and Matrix Compartments

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Brain Connectivity Is Not Only Lower but Different in Schizophrenia: A Combined Anatomical and Functional Approach

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A Possible Role for the Striatum in the Pathogenesis of the Cognitive Symptoms of Schizophrenia

(2010) Eleanor H. Simpson et al.   NEURON

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

(2009) Shaun M. Purcell et al.   NATURE

Cation-Chloride Cotransporters and Neuronal Function

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