Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance

Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neurons

(2021) Michihiro Toritsuka et al.   NEUROCHEMISTRY INTERNATIONAL

Gene Expression in Patient-Derived Neural Progenitors Implicates WNT5A Signaling in the Etiology of Schizophrenia

(2020) Oleg V. Evgrafov et al.   BIOLOGICAL PSYCHIATRY

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

(2020) Emily E. Burke et al.   Nature Communications

Sodium channels implement a molecular leaky integrator that detects action potentials and regulates neuronal firing

(2020) Marco A Navarro et al.   eLife

Polygenic Risk Scores Shed Light on the Relationship between Schizophrenia and Cognitive Functioning: Review and Meta-Analysis

(2020) Jasmina Mallet et al.   Journal of Clinical Medicine

Modeling the complex genetic architectures of brain disease

(2020) Michael B. Fernando et al.   NATURE GENETICS

Neuronal defects in a human cellular model of 22q11.2 deletion syndrome

(2020) Themasap A. Khan et al.   NATURE MEDICINE

Generation of 10 patient-specific induced pluripotent stem cells (iPSCs) to model Pitt-Hopkins Syndrome

(2020) S.R. Sripathy et al.   Stem Cell Research

From Basic Science to Clinical Application of Polygenic Risk Scores

(2020) Naomi R. Wray et al.   JAMA Psychiatry

The role of clustered protocadherins in neurodevelopment and neuropsychiatric diseases

(2020) Erin Flaherty et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients

(2020) Laura Stertz et al.   NEUROPSYCHOPHARMACOLOGY

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell–derived cortical interneurons from subjects with schizophrenia

(2019) Zhicheng Shao et al.   NATURE NEUROSCIENCE

iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function

(2019) Peiyan Ni et al.   MOLECULAR PSYCHIATRY

Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia

(2019) Leonardo Collado-Torres et al.   NEURON

Validity of polygenic risk scores: are we measuring what we think we are?

(2019) A Cecile J W Janssens   HUMAN MOLECULAR GENETICS

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

Sex-specific transcriptional and proteomic signatures in schizophrenia

(2019) Jari Tiihonen et al.   Nature Communications

Distinct Polygenic Score Profiles in Schizophrenia Subgroups With Different Trajectories of Cognitive Development

(2019) Dwight Dickinson et al.   AMERICAN JOURNAL OF PSYCHIATRY

Schizophrenia polygenic risk score predicts mnemonic hippocampal activity

(2018) Qiang Chen et al.   BRAIN

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

(2018) Andrew E. Jaffe et al.   NATURE NEUROSCIENCE

Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain

(2018) Eugenia Radulescu et al.   MOLECULAR PSYCHIATRY

Attacking Heterogeneity in Schizophrenia by Deriving Clinical Subgroups From Widely Available Symptom Data

(2017) Dwight Dickinson et al.   SCHIZOPHRENIA BULLETIN

Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains

(2017) Gabriel E. Hoffman et al.   Nature Communications

Integrative transcriptome network analysis of iPSC-derived neurons from schizophrenia and schizoaffective disorder patients with 22q11.2 deletion

(2016) Mingyan Lin et al.   BMC Systems Biology

Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes

(2016) Tune H. Pers et al.   HUMAN MOLECULAR GENETICS

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience

(2016) Jerome Mertens et al.   NATURE REVIEWS NEUROSCIENCE

The Societal Cost of Schizophrenia: A Systematic Review

(2016) Huajie Jin et al.   PHARMACOECONOMICS

Cell-specific restoration of stimulus preference after monocular deprivation in the visual cortex

(2016) T. Rose et al.   SCIENCE

Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells

(2016) Aaron Topol et al.   Cell Reports

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

(2015) Priya Srikanth et al.   Cell Reports

Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity

(2014) Ki-Jun Yoon et al.   Cell Stem Cell

Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia

(2014) K Brennand et al.   MOLECULAR PSYCHIATRY

Synaptic dysregulation in a human iPS cell model of mental disorders

(2014) Zhexing Wen et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

The response of NaV1.3 sodium channels to ramp stimuli: multiple components and mechanisms

(2012) Mark Estacion et al.   JOURNAL OF NEUROPHYSIOLOGY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Long-term inactivation particle for voltage-gated sodium channels

(2010) Katarzyna Dover et al.   JOURNAL OF PHYSIOLOGY-LONDON

Abnormal neural oscillations and synchrony in schizophrenia

(2010) Peter J. Uhlhaas et al.   NATURE REVIEWS NEUROSCIENCE

Cognitive Factor Structure and Invariance in People With Schizophrenia, Their Unaffected Siblings, and Controls

(2010) D. Dickinson et al.   SCHIZOPHRENIA BULLETIN

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

(2009) Noemi FUSAKI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES