Helicobacter pylori ‐derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3‐C3aR signalling

The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology

(2022) Junhua Xie et al.   Frontiers in Immunology

Association of hypertension with helicobacter pylori: A systematic review and meta‑analysis

(2022) Yizhen Fang et al.   PLoS One

The tremendous biomedical potential of bacterial extracellular vesicles

(2022) Junhua Xie et al.   TRENDS IN BIOTECHNOLOGY

An Updated Meta-Analysis of the Relationship Between Helicobacter pylori Infection and the Risk of Coronary Heart Disease

(2022) Ling Tong et al.   Frontiers in Cardiovascular Medicine

Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in mice

(2022) Ting Gong et al.   Frontiers in Cellular and Infection Microbiology

Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation

(2021) Pablo Largo-Barrientos et al.   NEURON

Multi-pathogen infections and Alzheimer’s disease

(2021) Dana Vigasova et al.   Microbial Cell Factories

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

(2021) Alessio Vittorio Colombo et al.   eLife

Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?

(2021) Giovanna Lalli et al.   EMBO Molecular Medicine

Importance of extracellular vesicle secretion at the blood–cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease

(2021) Charysse Vandendriessche et al.   Acta Neuropathologica Communications

Low-grade peripheral inflammation affects brain pathology in the AppNL-G-Fmouse model of Alzheimer’s disease

(2021) Junhua Xie et al.   Acta Neuropathologica Communications

Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe‐host‐communication in vivo

(2021) Miriam Bittel et al.   Journal of Extracellular Vesicles

Extracellular vesicles derived from the periodontal pathogen Filifactor alocis induce systemic bone loss through Toll‐like receptor 2

(2021) Hyun Young Kim et al.   Journal of Extracellular Vesicles

Role of Outer Membrane Vesicles From Helicobacter pylori in Atherosclerosis

(2021) Na Wang et al.   Frontiers in Cell and Developmental Biology

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

(2020) Heather C. Rice et al.   Molecular Neurodegeneration

Astrocytes and Microglia: In Sickness and in Health

(2020) Ilia D. Vainchtein et al.   TRENDS IN NEUROSCIENCES

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

(2020) Martí Colom-Cadena et al.   Alzheimers Research & Therapy

Helicobacter pylori infection as a risk factor for diabetes: a meta-analysis of case-control studies

(2020) Kamyar Mansori et al.   BMC GASTROENTEROLOGY

Association between Helicobacter Pylori infection and stroke: a meta-analysis of 273,135 patients

(2020) Mohamed Fahmy Doheim et al.   JOURNAL OF NEUROLOGY

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

(2020) Wei-Ting Chen et al.   CELL

The extracellular vesicle of gut microbial Paenalcaligenes hominis is a risk factor for vagus nerve-mediated cognitive impairment

(2020) Kyung-Eon Lee et al.   Microbiome

Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease

(2020) Lydia Durant et al.   Microbiome

Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases

(2020) Tim Bartels et al.   SCIENCE

Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation

(2020) Pankaj Deo et al.   Nature Microbiology

Delivery of Periodontopathogenic Extracellular Vesicles to Brain Monocytes and Microglial IL-6 Promotion by RNA Cargo

(2020) Jae Yeong Ha et al.   Frontiers in Molecular Biosciences

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Back Cover: Helicobacter pylori Growth Stage Determines the Size, Protein Composition, and Preferential Cargo Packaging of Outer Membrane Vesicles

(2019) Lauren Zavan et al.   PROTEOMICS

Dysregulated Lung Commensal Bacteria Drive Interleukin-17B Production to Promote Pulmonary Fibrosis through Their Outer Membrane Vesicles

(2019) Daping Yang et al.   IMMUNITY

Effective Visualization and Easy Tracking of Extracellular Vesicles in Glioma Cells

(2019) Abir Mondal et al.   BIOLOGICAL PROCEDURES ONLINE

Systemic inflammation impairs microglial Aβ clearance through NLRP 3 inflammasome

(2019) Dario Tejera et al.   EMBO JOURNAL

Extracellular RNAs in periodontopathogenic outer membrane vesicles promote TNF-α production in human macrophages and cross the blood–brain barrier in mice

(2019) Eun-Chong Han et al.   FASEB JOURNAL

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment

(2019) Shouchao Wei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Association of Intestinal Disorders with Parkinson’s Disease and Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2019) Pengfei Fu et al.   ACS Chemical Neuroscience

Alzheimer’s Disease and Helicobacter pylori Infection: Inflammation from Stomach to Brain?

(2019) Guillaume Albaret et al.   JOURNAL OF ALZHEIMERS DISEASE

The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection

(2018) N. Gorlé et al.   BRAIN BEHAVIOR AND IMMUNITY

Counteracting the effects of TNF receptor‐1 has therapeutic potential in Alzheimer's disease

(2018) Sophie Steeland et al.   EMBO Molecular Medicine

Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis

(2018) Pankaj Deo et al.   PLoS Pathogens

Alzheimer’s disease hypothesis and related therapies

(2018) Xiaoguang Du et al.   Translational Neurodegeneration

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

Review: Impact of Helicobacter pylori on Alzheimer's disease: What do we know so far?

(2017) Michael Doulberis et al.   HELICOBACTER

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins

(2017) Ryan Finethy et al.   mBio

Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury

(2017) Martina Bielaszewska et al.   PLoS Pathogens

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

Colocalization of synapse marker proteins evaluated by STED-microscopy reveals patterns of neuronal synapse distribution in vitro

(2016) Egor Dzyubenko et al.   JOURNAL OF NEUROSCIENCE METHODS

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Alzheimer’s disease and gut microbiota

(2016) Xu Hu et al.   Science China-Life Sciences

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

(2015) Carmen Schwechheimer et al.   NATURE REVIEWS MICROBIOLOGY

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Glial influence on the blood brain barrier

(2013) Jorge Ivan Alvarez et al.   GLIA

Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation

(2013) R E Vandenbroucke et al.   Mucosal Immunology

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

(2012) Dimitrije Krstic et al.   Journal of Neuroinflammation

Primary phagocytosis of viable neurons by microglia activated with LPS or Aβ is dependent on calreticulin/LRP phagocytic signalling

(2012) Michael Fricker et al.   Journal of Neuroinflammation

Matrix Metalloprotease 8-Dependent Extracellular Matrix Cleavage at the Blood-CSF Barrier Contributes to Lethality during Systemic Inflammatory Diseases

(2012) R. E. Vandenbroucke et al.   JOURNAL OF NEUROSCIENCE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE