Article
Neurosciences
Jaehong Park, Tae Jun Kim, Joo Hye Song, Hyemin Jang, Ji Sun Kim, Sung Hoon Kang, Hang-Rai Kim, Song Hwangbo, Hee Young Shin, Duk L. Na, Sang Won Seo, Hee Jin Kim, Jae J. Kim
Summary: This study found an association between H. pylori infection and reduced brain cortical thickness, especially in the parietal and occipital lobes. Multiple linear regression analysis showed that men with H. pylori infection exhibited changes in neurodegeneration.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Ashley D. Innis, Magdalena Tolea, James E. Galvin
Summary: This study found that the level of mindfulness in dementia patients and caregivers is closely related to their quality of life and cognitive performance. Better outcomes were observed when both patients and caregivers had higher levels of mindfulness.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Kym McNicholas, Maxime Francois, Jian-Wei Liu, James D. Doecke, Jane Hecker, Jeff Faunt, John Maddison, Sally Johns, Tara L. Pukala, Robert A. Rush, Wayne R. Leifert
Summary: This study identified biomarkers in saliva that can be used for early detection of cognitive impairment and Alzheimer's disease. The findings suggest that combinations of specific proteins can effectively distinguish patients with cognitive impairment and Alzheimer's disease from cognitively normal individuals.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Grzegorz Walkiewicz, Alicja Ronisz, Rita Van Ginderdeuren, Sophie Lemmens, Femke H. Bouwman, Jeroen J. M. Hoozemans, Tjado H. J. Morrema, Annemieke J. Rozemuller, Frederique J. Hart de Ruyter, Lies De Groef, Ingeborg Stalmans, Dietmar Rudolf Thal
Summary: This study reveals the presence of a distinct primary retinal tauopathy that is different from tauopathies in the brain. The stage of retinal p-tau pathology is correlated with age, AD, and inflammation, while vision impairment is associated with underlying eye diseases and the stage of retinal p-tau pathology.
ALZHEIMERS & DEMENTIA
(2023)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Review
Neurosciences
Shirley Tran, Sanjaya Kuruppu, Niwanthi W. Rajapakse
Summary: Hypertension is a major risk factor for vascular dementia and Alzheimer's disease, and chronic activation of the renin-angiotensin system contributes to neuroinflammation. Neuroinflammation induced by chronic RAS activation plays a key role in the pathogenesis of dementia, leading to cognitive impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Review
Biochemistry & Molecular Biology
Maria Fernanda Gonzalez, Paula Diaz, Alejandra Sandoval-Borquez, Daniela Herrera, Andrew F. G. Quest
Summary: Extracellular vesicles are important in host-pathogen interactions, playing a role in modulating inflammatory responses and promoting disease development. Both EVs from cells infected with H. pylori and H. pylori-OMVs are involved in the development of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Haitao Xi, Jinghuan Gan, Shuai Liu, Fei Wang, Zhichao Chen, Xiao-Dan Wang, Zhihong Shi, Yong Ji
Summary: This study evaluates the relationship between reproductive factors and cognitive impairment in Chinese women with natural menopause. The findings suggest that age at menopause, reproductive period, and number of pregnancies/parities are correlated with cognitive impairment and significantly impact the risk of mild cognitive impairment and dementia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Psychiatry
Azizi Seixas, Farid A. Rajabli, Margaret Pericak-Vance, Girardin L. Jean-Louis, Ioannis Tarnanas
Summary: This study investigated a digital neuro signature biomarker in predicting cognitive functioning and changes in older adults, compared to traditional biomarkers. The study also explored which demographic and clinical factors predicted the digital neuro signature biomarker in cognitively impaired and healthy older adults. The findings suggest that digital biomarkers may offer more reliable predictions of cognitive functioning and changes in older adults compared to traditional biomarkers.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Nutrition & Dietetics
AlMa Mihaela Dimache, Delia Lidia Salaru, Radu Sascau, Cristian Statescu
Summary: The burden of cognitive disorders is substantial and varies in etiology and severity. Triglyceride levels may be associated with cognitive function, but not all studies have found this link. Further research is needed to evaluate the relationship between triglycerides and cognitive impairment.
Article
Clinical Neurology
M. -Marsel Mesulam, Christina A. Coventry, Eileen H. Bigio, Jaiashre Sridhar, Nathan Gill, Angela J. Fought, Hui Zhang, Cynthia K. Thompson, Changiz Geula, Tamar Gefen, Margaret Flanagan, Qinwen Mao, Sandra Weintraub, Emily J. Rogalski
Summary: Primary progressive aphasia is a neurodegenerative disease that selectively impairs language function. Autopsies and longitudinal studies have shown that primary progressive aphasia has various neuropathological changes, with Alzheimer's disease being the most common. Different variants of primary progressive aphasia have distinct neuropathological correlates, and word comprehension impairments are strong predictors of underlying neuropathology. Different types of primary progressive aphasia have different patterns of cortical atrophy, but all show severe damage to the left hemisphere language network. This study is important for understanding the neuropathological and clinical differences in primary progressive aphasia.
Review
Clinical Neurology
Ya-Ru Zhang, Wei Xu, Wei Zhang, Hui-Fu Wang, Ya-Nan Ou, Yi Qu, Xue-Ning Shen, Shi-Dong Chen, Kai-Min Wu, Qian-Hua Zhao, Hai-Ning Zhang, Li Sun, Qiang Dong, Lan Tan, Lei Feng, Can Zhang, Evangelos Evangelou, A. David Smith, Jin-Tai Yu
Summary: This study conducted an umbrella review to evaluate the strength and validity of the associations between modifiable factors and dementia and cognitive impairment. The results identified several modifiable risk factors, including early-life education, plasma glucose, BMI, atrial fibrillation, benzodiazepine use, and gait speed, that have convincing evidence of association. The study also found suggestive to highly suggestive evidence for other factors such as blood pressure, homocysteine, diet, and physical activity. Mendelian randomization studies provided further evidence for the causal relationships of education and plasma glucose with Alzheimer's disease.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Letter
Gastroenterology & Hepatology
Jannis Kountouras, Apostolis Papaefthymiou, Stergios A. Polyzos, Christos Liatsos, Maria Tzitiridou-Chatzopoulou, Dimitrios Chatzopoulos, Elisabeth Vardaka, Dimitra Gialamprinou, Georgios Kotronis, Tharshika Thavayogarajah, Michael Doulberis
DIGESTIVE DISEASES AND SCIENCES
(2023)
Editorial Material
Peripheral Vascular Disease
Jannis Kountouras, Apostolis Papaefthymiou, Stergios A. Polyzos, Foteini Kyrailidi, Michael Doulberis
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Letter
Oncology
Jannis Kountouras, Apostolis Papaefthymiou, Stergios A. A. Polyzos, Michael Doulberis
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Letter
Gastroenterology & Hepatology
Jannis Kountouras, Apostolis Papaefthymiou, Stergios A. Polyzos, Evangelos Kazakos, Dimitrios Tzilves, Maria Touloumtzi, Dimitrios Chatzopoulos, Maria Tzitiridou-Chatzopoulou, Christos Liatsos, Christos Zavos, John Kavaliotis, Hasan Kulaksiz, Michael Doulberis
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Jannis Kountouras, Apostolis Papaefthymiou, Stergios A. A. Polyzos, Evangelos Kazakos, Dimitrios Tzilves, Georgia Lazaraki, Christos Zavos, Elisabeth Vardaka, Stergios Arapoglou, Foteini Kyrailidi, Maria C. C. Mouratidou, Michael Doulberis
JOURNAL OF VIRAL HEPATITIS
(2023)
Review
Immunology
Jannis Kountouras, Evangelos Kazakos, Stergios A. Polyzos, Apostolis Papaefthymiou, Christos Zavos, Maria Tzitiridou-Chatzopoulou, Dimitrios Chatzopoulos, Elisabeth Vardaka, Anthia Gatopoulou, Foteini Kyrailidi, Maria C. Mouratidou, Michael Doulberis
Summary: This article discusses the potential impact of trained immunity on the pathophysiology of MAFLD, revealing the complex immunobiology of the disease and providing potential therapeutic strategies.
CLINICAL IMMUNOLOGY
(2023)
Letter
Geriatrics & Gerontology
Jannis Kountouras, Apostolis Papaefthymiou, Christos Zavos, Dimitrios Chatzopoulos, Maria Tzitiridou-Chatzopoulou, John Kavaliotis, Dimitrios Tzilves, Georgia Lazaraki, Elisabeth Vardaka, Michael Doulberis
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Infectious Diseases
Olga. P. Nyssen, Pietro Pratesi, Miguel. A. Spinola, Laimas Jonaitis, Angeles Perez-Aisa, Dino Vaira, Ilaria Maria Saracino, Matteo Pavoni, Giulia Fiorini, Bojan Tepes, Dmitry. S. Bordin, Irina Voynovan, Angel Lanas, Samuel. J. Martinez-Dominguez, Enrique Alfaro, Luis Bujanda, Manuel Pabon-Carrasco, Luis Hernandez, Antonio Gasbarrini, Juozas Kupcinskas, Frode Lerang, Sinead. M. Smith, Oleksiy Gridnyev, Marcis Leja, Theodore Rokkas, Ricardo Marcos-Pinto, Antonio Mestrovic, Wojciech Marlicz, Vladimir Milivojevic, Halis Simsek, Lumir Kunovsky, Veronika Papp, Perminder. S. Phull, Marino Venerito, Lyudmila Boyanova, Doron Boltin, Yaron Niv, Tamara Matysiak-Budnik, Michael Doulberis, Daniela Dobru, Vincent Lamy, Lisette. G. Capelle, Emilijia Nikolovska Trpchevska, Leticia Moreira, Anna Cano-Catalia, Pablo Parra, Francis Megraud, Colm O'Morain, Guillermo. J. Ortega, Javier. P. Gisbert
Summary: The segmentation of patients into homogeneous groups can improve the effectiveness of eradication therapy. The study aims to determine the most important treatment strategies used in Europe and evaluate the effectiveness of first-line treatments based on year and country. The analysis found that the overall treatment effectiveness increased from 87% in 2013 to 93% in 2022, with the highest effectiveness achieved in 2022 using bismuth-quadruple therapy in Spain. Cluster analysis identified homogeneous treatment groups and assessed the effectiveness of different first-line treatments.
Review
Biochemistry & Molecular Biology
Iasonas Dermitzakis, Maria Eleni Manthou, Soultana Meditskou, Marie-eve Tremblay, Steven Petratos, Lida Zoupi, Marina Boziki, Evangelia Kesidou, Constantina Simeonidou, Paschalis Theotokis
Summary: Microglia are tissue-resident macrophages of the CNS and play a vital role in homeostasis and pathophysiology of the brain. Their unique characteristics and origin have been a subject of intense research. This review presents recent evidence on the birthplace of microglia and the molecular factors involved in their development. The data collected can potentially provide insights into the therapeutic potential of microglia for CNS disorders.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Medicine, General & Internal
Jannis Kountouras, Michael Doulberis, Apostolis Papaefthymiou, Stergios A. Polyzos, Christos Zavos, Evangelos Kazakos, Stergios Arapoglou, Foteini Kyrailidi, Maria C. Mouratidou, Marina Boziki, Elisabeth Vardaka
Summary: Helicobacter pylori infection is a global burden affecting over 50% of the world's population. It is not only associated with gastric pathologies like peptic ulcers and gastric cancer, but also implicated in the development of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and/or glaucoma by inducing brain cortical thinning.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Jannis Kountouras, Maria Tzitiridou-Chatzopoulou, Apostolis Papaefthymiou, Dimitrios Chatzopoulos, Michael Doulberis
Summary: Frail, elderly individuals have poor immune response after COVID-19 mRNA vaccination, possibly due to inflame-ageing and immune-senescence mechanisms. The complex interaction between cytokines and microbiota also plays a role in this inflammatory cascade. Despite their immunological significance, this population has been rarely included in clinical trials of mRNA vaccination.
MEDICINA-LITHUANIA
(2023)
Article
Endocrinology & Metabolism
Stergios A. Polyzos, Apostolis Papaefthymiou, Michael Doulberis, Jannis Kountouras
Summary: This study validates a novel non-invasive index, the NAFLD test, for the diagnosis of NAFLD and the distinction between NAFL and NASH, showing acceptable accuracy.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Rahel Looser, Michael Doulberis, Jean-Benoit Rossel, Yannick Franc, Daniel Mueller, Luc Biedermann, Gerhard Rogler
Summary: There is conflicting data on whether co-treatment with 5-aminosalicylic acid (5-ASA) in inflammatory bowel disease patients under azathioprine (AZA) or 6-mercaptopurine (6-MP) therapy may affect 6-thioguanine nucleotide (6-TGN) concentrations and put patients at risk of side effects. This study aimed to determine 6-TGN levels in patients treated with AZA/6-MP, either alone or in combination with 5-ASA. The results showed that blood concentrations of 6-TGN and 6-methylmercaptopurine ribonucleotides (6-MMPR) did not differ between patients with and without 5-ASA co-treatment.
ANNALS OF GASTROENTEROLOGY
(2023)
Review
Endocrinology & Metabolism
Apostolis Papaefthymiou, Michael Doulberis, Kyriaki Karafyllidou, Eleftherios Chatzimichael, Georgia Deretzi, Aristomenis K. Exadaktylos, Fotios Sampsonas, Athanasios Gelasakis, Spyros I. Papamichos, Georgios Kotronis, Dimitra Gialamprinou, Elisabeth Vardaka, Stergios A. Polyzos, Jannis Kountouras
Summary: Nonalcoholic fatty liver disease (NAFLD) is a disease with unclear pathogenesis and increasing prevalence, for which there is currently no approved pharmacotherapy. This article focuses on the potential future pharmacological management of NAFLD through spironolactone, a cost-effective medication.
MINERVA ENDOCRINOLOGY
(2023)