Integrin αvβ3 Is a Master Regulator of Resistance to TKI-Induced Ferroptosis in HER2-Positive Breast Cancer
出版年份 2023 全文链接
标题
Integrin αvβ3 Is a Master Regulator of Resistance to TKI-Induced Ferroptosis in HER2-Positive Breast Cancer
作者
关键词
-
出版物
Cancers
Volume 15, Issue 4, Pages 1216
出版商
MDPI AG
发表日期
2023-02-15
DOI
10.3390/cancers15041216
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Integrin α3β1 Promotes Invasive and Metastatic Properties of Breast Cancer Cells through Induction of the Brn-2 Transcription Factor
- (2021) Rakshitha Pandulal Miskin et al. Cancers
- Pertuzumab Plus High-Dose Trastuzumab in Patients With Progressive Brain Metastases and HER2-Positive Metastatic Breast Cancer: Primary Analysis of a Phase II Study
- (2021) Nancy U. Lin et al. JOURNAL OF CLINICAL ONCOLOGY
- Targeted therapy to β3 integrin reduces chemoresistance in breast cancer bone metastases
- (2021) Gregory C. Fox et al. MOLECULAR CANCER THERAPEUTICS
- HER2-positive breast cancer and tyrosine kinase inhibitors: the time is now
- (2021) Ilana Schlam et al. npj Breast Cancer
- Ferroptosis Suppressor Protein 1 (FSP1) and Coenzyme Q10 Cooperatively Suppress Ferroptosis
- (2020) Kamyar Hadian BIOCHEMISTRY
- Hybrid Epithelial/Mesenchymal State in Cancer Metastasis: Clinical Significance and Regulatory Mechanisms
- (2020) Tsai-Tsen Liao et al. Cells
- Integrin αvβ3‐Akt signalling plays a role in radioresistance of melanoma
- (2020) Hyuntaik Im et al. EXPERIMENTAL DERMATOLOGY
- NRF2-GPX4/SOD2 axis imparts resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer cells
- (2020) Chun-shuang Ma et al. ACTA PHARMACOLOGICA SINICA
- 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5)†
- (2020) F. Cardoso et al. ANNALS OF ONCOLOGY
- Iron Metabolism in Ferroptosis
- (2020) Xin Chen et al. Frontiers in Cell and Developmental Biology
- Abnormally activated OPN/integrin αVβ3/FAK signalling is responsible for EGFR-TKI resistance in EGFR mutant non-small-cell lung cancer
- (2020) Yulong Fu et al. Journal of Hematology & Oncology
- Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib
- (2020) Xiang Song et al. Frontiers in Oncology
- Blockade of integrin β3 signals to reverse the stem-like phenotype and drug resistance in melanoma
- (2019) Xiaoxia Zhu et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
- (2019) Matthew Dodson et al. Redox Biology
- GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis
- (2019) Giovanni C. Forcina et al. PROTEOMICS
- TBCRC 022: A Phase II Trial of Neratinib and Capecitabine for Patients With Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases
- (2019) Rachel A. Freedman et al. JOURNAL OF CLINICAL ONCOLOGY
- Recombinant RGD-disintegrin DisBa-01 blocks integrin αvβ3 and impairs VEGF signaling in endothelial cells
- (2019) Taís M. Danilucci et al. Cell Communication and Signaling
- BEECH: A dose-finding run-in followed by a randomised phase 2 study assessing the efficacy of AKT inhibitor capivasertib (AZD5363) combined with paclitaxel in patients with oestrogen receptor-positive advanced or metastatic breast cancer, and in a PIK3CA mutant sub-population
- (2019) N C Turner et al. ANNALS OF ONCOLOGY
- Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells
- (2019) Shiyao Sui et al. Cell Death & Disease
- Role of Integrins in Resistance to Therapies Targeting Growth Factor Receptors in Cancer
- (2019) Elisabete Cruz da Silva et al. Cancers
- Alphavbeta3 integrin blocking inhibits apoptosis and induces autophagy in murine breast tumor cells
- (2019) Rafael Luis Bressani Lino et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- T-DM1 Efficacy in Patients With HER2-positive Metastatic Breast Cancer Progressing After a Taxane Plus Pertuzumab and Trastuzumab: An Italian Multicenter Observational Study
- (2019) Benedetta Conte et al. Clinical Breast Cancer
- FSP1 is a glutathione-independent ferroptosis suppressor
- (2019) Sebastian Doll et al. NATURE
- Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis
- (2018) Soo-Hyun Kim et al. Disease Models & Mechanisms
- Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: ASCO Clinical Practice Guideline Update
- (2018) Sharon H. Giordano et al. JOURNAL OF CLINICAL ONCOLOGY
- Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells
- (2018) Yun Sun et al. Cell Death & Disease
- The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells
- (2018) Mami Sato et al. Scientific Reports
- RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer
- (2018) Xinbing Sui et al. Frontiers in Pharmacology
- PIKHER2: A phase IB study evaluating buparlisib in combination with lapatinib in trastuzumab-resistant HER2-positive advanced breast cancer
- (2017) Mathilde Guerin et al. EUROPEAN JOURNAL OF CANCER
- EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
- (2017) Tsukasa Shibue et al. Nature Reviews Clinical Oncology
- Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells
- (2017) Brian Bierie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transcriptional Regulation by Nrf2
- (2017) Claudia Tonelli et al. ANTIOXIDANTS & REDOX SIGNALING
- The Roles of NRF2 in Modulating Cellular Iron Homeostasis
- (2017) Michael John Kerins et al. ANTIOXIDANTS & REDOX SIGNALING
- Autophagy promotes ferroptosis by degradation of ferritin
- (2016) Wen Hou et al. Autophagy
- Antagonizing Integrin 3 Increases Immunosuppression in Cancer
- (2016) X. Su et al. CANCER RESEARCH
- Mechanisms of ferroptosis
- (2016) Jennifer Yinuo Cao et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Phase I Study of an AKT Inhibitor (MK-2206) Combined with Lapatinib in Adult Solid Tumors Followed by Dose Expansion in Advanced HER2+ Breast Cancer
- (2016) K. B. Wisinski et al. CLINICAL CANCER RESEARCH
- β3 integrin promotes chemoresistance to epirubicin in MDA-MB-231 through repression of the pro-apoptotic protein, BAD
- (2016) Madhumathy G. Nair et al. EXPERIMENTAL CELL RESEARCH
- Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells
- (2016) S Ma et al. Cell Death & Disease
- Tumour but not stromal expression ofβ3 integrin is essential, and is required early, for spontaneous dissemination of bone-metastatic breast cancer
- (2015) Rachel Zoe Carter et al. JOURNAL OF PATHOLOGY
- Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia
- (2015) Cheng-Shi Xu et al. Journal of Translational Medicine
- Interactions between αv-Integrin and HER2 and Their Role in the Invasive Phenotype of Breast Cancer Cells In Vitro and in Rat Brain
- (2015) Sangeet Lal et al. PLoS One
- Understanding Heterogeneity and Permeability of Brain Metastases in Murine Models of HER2-Positive Breast Cancer Through Magnetic Resonance Imaging: Implications for Detection and Therapy
- (2015) Donna H. Murrell et al. Translational Oncology
- New mechanistic insights of integrin β1 in breast cancer bone colonization
- (2015) Laure Thibaudeau et al. Oncotarget
- Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention
- (2014) Samantha Kaufhold et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition
- (2014) Laetitia Seguin et al. NATURE CELL BIOLOGY
- Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin
- (2014) Johannes F Van Agthoven et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- SLUG: Critical regulator of epithelial cell identity in breast development and cancer
- (2014) Sarah Phillips et al. Cell Adhesion & Migration
- Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
- (2014) Scott J Dixon et al. eLife
- Spontaneous Epithelial-Mesenchymal Transition and Resistance to HER-2-Targeted Therapies in HER-2-Positive Luminal Breast Cancer
- (2013) David Lesniak et al. PLoS One
- Epithelial-to-mesenchymal transition (EMT) confers primary resistance to trastuzumab (Herceptin)
- (2012) Cristina Oliveras-Ferraros et al. CELL CYCLE
- v 3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1
- (2012) T. Gianni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Trastuzumab: Updated Mechanisms of Action and Resistance in Breast Cancer
- (2012) Thuy Vu et al. Frontiers in Oncology
- Integrin β4 Signaling Promotes Mammary Tumor Cell Adhesion to Brain Microvascular Endothelium by Inducing ErbB2-Mediated Secretion of VEGF
- (2011) Jie Fan et al. ANNALS OF BIOMEDICAL ENGINEERING
- Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation
- (2011) Carlos Mas-Moruno et al. Anti-Cancer Agents in Medicinal Chemistry
- The effect of cell–ECM adhesion on signalling via the ErbB family of growth factor receptors
- (2011) Xanthippi Alexi et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Crosstalk between integrin and receptor tyrosine kinase signaling in breast carcinoma progression
- (2011) Young-Hwa Soung et al. BMB Reports
- Central Nervous System Metastases in Patients with HER2-Positive Metastatic Breast Cancer: Incidence, Treatment, and Survival in Patients from registHER
- (2011) A. M. Brufsky et al. CLINICAL CANCER RESEARCH
- Integrin-dependent response to laminin-511 regulates breast tumor cell invasion and metastasis
- (2011) Nicole Kusuma et al. INTERNATIONAL JOURNAL OF CANCER
- Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer
- (2011) José Baselga et al. NEW ENGLAND JOURNAL OF MEDICINE
- Metastatic Behavior of Breast Cancer Subtypes
- (2010) Hagen Kennecke et al. JOURNAL OF CLINICAL ONCOLOGY
- Triple-negative and HER2-overexpressing breast cancers exhibit an elevated risk and an earlier occurrence of cerebral metastases
- (2009) Florian Heitz et al. EUROPEAN JOURNAL OF CANCER
- Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
- (2009) Andrew R Reynolds et al. NATURE MEDICINE
- Activation of tumor cell integrin v 3 controls angiogenesis and metastatic growth in the brain
- (2009) M. Lorger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Mammary Progenitor Marker CD61/ 3 Integrin Identifies Cancer Stem Cells in Mouse Models of Mammary Tumorigenesis
- (2008) F. Vaillant et al. CANCER RESEARCH
- Phase II Trial of Lapatinib for Brain Metastases in Patients With Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer
- (2008) Nancy U. Lin et al. JOURNAL OF CLINICAL ONCOLOGY
- v 3 Integrin-Mediated Drug Resistance in Human Laryngeal Carcinoma Cells Is Caused by Glutathione-Dependent Elimination of Drug-Induced Reactive Oxidative Species
- (2008) A. Brozovic et al. MOLECULAR PHARMACOLOGY
- The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling
- (2008) M Chekenya et al. ONCOGENE
- Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer
- (2007) Farhad Vesuna et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Membrane-Spanning Domain of CD98 Heavy Chain Promotes αvβ3Integrin Signals in Human Extravillous Trophoblasts
- (2007) Maryam Kabir-Salmani et al. MOLECULAR ENDOCRINOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search