Article
Biology
Xiaoyan Dai, Yanli Xin, Weizhi Xu, Xinxia Tian, Xiaofan Wei, Hongquan Zhang
Summary: In breast cancer cells, acetylation by CBP increases the stability of Slug, promoting epithelial to mesenchymal transition (EMT) and migration of breast cancer cells.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Review
Oncology
Madison N. Wicker, Kay-Uwe Wagner
Summary: Cellular plasticity, the ability of cells to change their identity, plays a crucial role in mammary gland development and breast cancer progression. This review provides a comprehensive overview of the factors and mechanisms that promote cellular plasticity in the mammary gland. It discusses changes in cell identity during normal development, the role of the gestation cycle, and highlights the importance of the microenvironment and extracellular matrix. The review also explores cellular reprogramming during mammary tumorigenesis, focusing on the origin of basal-like breast cancers and the role of oncogenic signaling networks. Additionally, recent advances in genetically engineered models to study cellular plasticity in vivo are discussed.
Article
Multidisciplinary Sciences
Shaheen S. Sikandar, Gunsagar S. Gulati, Jane Antony, Isobel Fetter, Angera H. Kuo, William Hai Dang Ho, Veronica Haro-Acosta, Soumyashree Das, Chloe B. Steen, Thiago Almeida Pereira, Dalong Qian, Philip A. Beachy, Fredrick Dirbas, Kristy Red-Horse, Terence H. Rabbitts, Jean Paul Thiery, Aaron M. Newman, Michael F. Clarke
Summary: A minority population of immature tumor epithelial cells with angiogenic features, marked by the oncogene LMO2, has been identified in human breast tumor biopsies. Higher abundance of LMO2(+) basal cells is correlated with tumor endothelial content and predicts poor prognosis. LMO2 binds to STAT3 and is required for STAT3 activation, promoting breast cancer metastasis.
Review
Biochemistry & Molecular Biology
Marina Ibragimova, Matvey Tsyganov, Nikolai Litviakov
Summary: This review discusses the main mechanisms of CSCs in breast cancer, including markers and signaling pathways, heterogeneity, plasticity, and ecological behavior. The study also considers the significance of dynamic heterogeneity of CSCs and dynamic transitions between CSCs and non-CSCs for metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Xian Liu, Qian Feng, Yanru Zhang, PengSheng Zheng, Nan Cui
Summary: The study confirmed the positive effect of Slug in promoting cell motility and metastasis in cervical cancer cells, with RNA-Seq analysis revealing the trans-suppression effect of Slug on EpCAM. Restoring EpCAM expression attenuated cell motility and promoted cell growth in Slug-overexpressing cells, and a negative correlation between Slug and EpCAM expression was verified in human squamous cervical carcinoma samples.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Liubov A. Tashireva, Olga E. Savelieva, Evgeniya S. Grigoryeva, Yuri V. Nikitin, Evgeny V. Denisov, Sergey V. Vtorushin, Marina V. Zavyalova, Nadezhda V. Cherdyntseva, Vladimir M. Perelmuter
Summary: Significant heterogeneity of CTCs in breast cancer is observed, particularly in terms of EMT plasticity. The majority of CTC phenotypes exhibit epithelial-mesenchymal plasticity, contributing to the understanding of the metastatic process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Pradeep Kumar Rajput, Jiten R. Sharma, Umesh C. S. Yadav
Summary: Obesity has become a global pandemic and is associated with an increase in breast cancer incidence. This review discusses the cellular and molecular insights into the visfatin-mediated cellular plasticity programs in breast cancer, including EMT and EndoMT. The presence of visfatin in the tumor microenvironment and its effects on cancer cells and stromal cells are also explored. The review highlights potential therapeutic targets for effective breast cancer treatment.
Article
Oncology
Abdel-Rahman N. Zekri, Abeer Bahnassy, Magda Mourad, Ibrahim Malash, Ola Ahmed, Mona S. Abdellateif
Summary: This study characterized breast cancer stem cells (BCSCs) through genetic profiling, revealing specific molecular profiles that differ according to their phenotypes. These profiles could potentially impact patients' prognosis and outcome.
CANCER CELL INTERNATIONAL
(2022)
Article
Biology
Louisiane Perrin, Elizaveta Belova, Battuya Bayarmagnai, Erkan Tuezel, Bojana Gligorijevic
Summary: Invasive and non-invasive cancer cells can invade together during cooperative invasion. A small number of invasive cells with invadopodia can drive the metastasis of heterogeneous cell clusters, and the formation of invadopodia in leader cells is essential for cooperative invasion.
COMMUNICATIONS BIOLOGY
(2022)
Review
Oncology
Caroline J. J. Campbell, Brian W. W. Booth
Summary: The tumor microenvironment plays a critical role in tumor initiation, progression, and metastasis of various cancers, including breast cancer. The complex interaction between tumor cells and the microenvironment affects tumor behavior and patient response to therapies. This review highlights the importance of the normal mammary microenvironment in redirecting tumorigenic cells to assume a non-tumorigenic phenotype.
Article
Oncology
Rui-ji Liu, Zhi-Peng Xu, Xiang Huang, Bin Xu, Ming Chen
Summary: YY1 is identified as a dysregulated transcription factor that plays a key role in neuroendocrine prostate cancer progression. Androgen deprivation therapy stabilizes YY1 protein, enhancing its transcriptional activity and promoting cellular plasticity through the non-canonical Wnt pathway.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Mami Kurosaki, Mineko Terao, Dawei Liu, Adriana Zanetti, Luca Guarrera, Marco Bolis, Maurizio Gianni, Gabriela Paroni, Gregory J. Goodall, Enrico Garattini
Summary: Circular RNAs are important regulatory molecules in cellular processes and may be involved in tumor growth and diffusion. The circular RNA from the DOCK1 gene shows differential expression in breast cancer cell lines with different phenotypes and influences the expression of common genes. The study provides insights into the role of specific circular RNAs in the generation and progression of breast cancer.
Article
Oncology
Jianchao Zhang, Xiaokai Fan, Yunfan Zhou, Liang Chen, Hai Rao
Summary: PRMT5 and LSD1 form a complex with Slug and promote breast cancer invasion. They inhibit E-cadherin expression and activate vimentin expression through dual transcriptional activities. Both PRMT5 and LSD1 are coordinately expressed in breast cancer patients and simultaneous inhibition of both proteins shows a synergetic effect in inhibiting breast tumor growth and metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sergey E. Parfenyev, Sergey V. Shabelnikov, Elena N. Tolkunova, Nickolai A. Barlev, Alexey G. Mittenberg
Summary: P53 plays a critical role in protecting the genome and preventing tumor formation, including metastases. The interaction between p53 and the transcription factor Zeb1 is important in carcinogenesis, particularly in the process of epithelial to mesenchymal transition (EMT). Additionally, the composition of Zeb1 interactome is affected by the presence of cancer stem cells and the level of Oct4/Sox2 expression, indicating that stemness influences the specificity of Zeb1 interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Taylor R. Rutherford, Alan M. Elder, Traci R. Lyons
Summary: The study reveals that SEMA7A promotes anoikis resistance in mammary epithelial cells and plays a role during mammary gland involution. SEMA7A is primarily expressed in cells expressing alpha 6-integrin, and a decrease in luminal progenitor cells is observed in SEMA7A-/- mice during involution.
CELL DEATH & DISEASE
(2021)