Enriched Environment Attenuates Ferroptosis after Cerebral Ischemia/Reperfusion Injury via the HIF-1α-ACSL4 Pathway

Ferroptosis—A Novel Mechanism With Multifaceted Actions on Stroke

(2022) Xiao-Ling Fang et al.   Frontiers in Neurology

ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury

(2022) Yue Wang et al.   Redox Biology

Treadmill Training Reduces Cerebral Ischemia-Reperfusion Injury by Inhibiting Ferroptosis through Activation of SLC7A11/GPX4

(2022) Tongye Liu et al.   Oxidative Medicine and Cellular Longevity

The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components

(2022) Kailin Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

(2021) Yu Cui et al.   BRAIN BEHAVIOR AND IMMUNITY

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

(2021) Chuan’ai Chen et al.   Cell Death & Disease

Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats

(2021) Linglei Kong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis

(2021) Junmin Chen et al.   Frontiers in Cellular Neuroscience

Baicalin Prevents Myocardial Ischemia/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis

(2021) Zhenyu Fan et al.   Frontiers in Pharmacology

Diabetic ferroptosis plays an important role in triggering on inflammation in diabetic wound

(2021) Shuangwen Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ferroptosis-Strengthened Metabolic and Inflammatory Regulation of Tumor-Associated Macrophages Provokes Potent Tumoricidal Activities

(2021) Zhengying Gu et al.   NANO LETTERS

Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation

(2021) Yanhong Shou et al.   Cell Death & Disease

Enriched Environment Attenuates Pyroptosis to Improve Functional Recovery After Cerebral Ischemia/Reperfusion Injury

(2021) Jingying Liu et al.   Frontiers in Aging Neuroscience

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

Empagliflozin alleviates neuronal apoptosis induced by cerebral ischemia/reperfusion injury through HIF-1α/VEGF signaling pathway

(2020) Rania G. Abdel-latif et al.   ARCHIVES OF PHARMACAL RESEARCH

Inhibition of double‐strand DNA‐sensing cGAS ameliorates brain injury after ischemic stroke

(2020) Qian Li et al.   EMBO Molecular Medicine

Ferroptosis as an emerging target in inflammatory diseases

(2020) Huimin Mao et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The emerging role of ferroptosis in inflammation

(2020) Yitian Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis

(2020) Dominik C. Fuhrmann et al.   Redox Biology

Targeting miR‐124/Ferroportin signaling ameliorated neuronal cell death through inhibiting apoptosis and ferroptosis in aged intracerebral hemorrhage murine model

(2020) Wen‐Dai Bao et al.   AGING CELL

Emerging connectivity of programmed cell death pathways and its physiological implications

(2020) Sammy Bedoui et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Iron Metabolism in Ferroptosis

(2020) Xin Chen et al.   Frontiers in Cell and Developmental Biology

The Metabolic Underpinnings of Ferroptosis

(2020) Jiashuo Zheng et al.   Cell Metabolism

Targeting miR-10a-5p/IL-6R axis for reducing IL-6-induced cartilage cell ferroptosis

(2020) Sheng Bin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Chondrocyte ferroptosis contribute to the progression of osteoarthritis

(2020) Xudong Yao et al.   Journal of Orthopaedic Translation

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

Environmental enrichment, new neurons and the neurobiology of individuality

(2019) Gerd Kempermann   NATURE REVIEWS NEUROSCIENCE

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

(2019) Shinya Tsurusaki et al.   Cell Death & Disease

Roles of HIFs and VEGF in angiogenesis in the retina and brain

(2019) Amir Rattner et al.   JOURNAL OF CLINICAL INVESTIGATION

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Environmental enrichment cognitive neuroprotection in an experimental model of cerebral ischemia: biochemical and molecular aspects

(2018) Lara Vezula Gonçalves et al.   BEHAVIOURAL BRAIN RESEARCH

Enriched environment promotes post-stroke neurogenesis through NF-κB-mediated secretion of IL-17A from astrocytes

(2018) Yujing Zhang et al.   BRAIN RESEARCH

Enriched housing promotes post-stroke neurogenesis through calpain 1-STAT3/HIF-1α/VEGF signaling

(2018) Xiaoying Wu et al.   BRAIN RESEARCH BULLETIN

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Use of Outpatient Rehabilitation Among Adult Stroke Survivors — 20 States and the District of Columbia, 2013, and Four States, 2015

(2018) Carma Ayala et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Current advances in ischemic stroke research and therapies

(2018) Derek Barthels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice

(2018) Saravanan S. Karuppagounder et al.   ANNALS OF NEUROLOGY

Cerebrovascular Disease

(2018) Fan Z. Caprio et al.   MEDICAL CLINICS OF NORTH AMERICA

A Very Early Rehabilitation Trial after stroke (AVERT): a Phase III, multicentre, randomised controlled trial

(2017) Peter Langhorne et al.   HEALTH TECHNOLOGY ASSESSMENT

Anti-inflammatory and immunomodulatory mechanisms of atorvastatin in a murine model of traumatic brain injury

(2017) Xin Xu et al.   Journal of Neuroinflammation

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Effect of Physical and Social Components of Enriched Environment on Astrocytes Proliferation in Rats After Cerebral Ischemia/Reperfusion Injury

(2017) Xiuping Chen et al.   NEUROCHEMICAL RESEARCH

DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury

(2015) A. Liesz et al.   JOURNAL OF NEUROSCIENCE

Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke

(2015) Tudor G. Jovin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Promoting endothelial function by S-nitrosoglutathione through the HIF-1α/VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats

(2015) Mushfiquddin Khan et al.   Drug Design Development and Therapy

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke

(2014) Saif Ahmad et al.   NEUROTOXICOLOGY

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

An Updated Definition of Stroke for the 21st Century

(2013) Ralph L. Sacco et al.   STROKE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Pyruvate Protects the Brain Against Ischemia–Reperfusion Injury by Activating the Erythropoietin Signaling Pathway

(2012) Myoung-Gwi Ryou et al.   STROKE

Selective Inhibition of Early-but Not Late-Expressed HIF-1α Is Neuroprotective in Rats after Focal Ischemic Brain Damage

(2010) Shiu-Hwa Yeh et al.   BRAIN PATHOLOGY

Hypoxia Inducible Factor 1 as a Therapeutic Target in Ischemic Stroke

(2009) Honglian Shi   CURRENT MEDICINAL CHEMISTRY

Specific inhibition of hypoxia inducible factor 1 exaggerates cell injury induced byin vitroischemia through deteriorating cellular redox environment

(2009) Shuhong Guo et al.   JOURNAL OF NEUROCHEMISTRY

Early inhibition of HIF-1α with small interfering RNA reduces ischemic–reperfused brain injury in rats

(2009) Chunhua Chen et al.   NEUROBIOLOGY OF DISEASE

Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1α and erythropoietin

(2008) Yun-Xia Li et al.   Neuroscience Bulletin