N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

(2017) Marietta Zille et al.   STROKE

Swollen Nuclei Signal from the Grave

(2016) Wakam Chang et al.   CELL

The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation

(2016) Balázs Enyedi et al.   CELL

Inhibition of Leukotriene B 4 Action Mitigates Intracerebral Hemorrhage-Associated Pathological Events in Mice

(2016) Masanori Hijioka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial

(2016) Daniel F Hanley et al.   LANCET NEUROLOGY

Botanical Polyphenols Mitigate Microglial Activation and Microglia-Induced Neurotoxicity: Role of Cytosolic Phospholipase A2

(2016) Dennis Y. Chuang et al.   NEUROMOLECULAR MEDICINE

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models

(2016) Saravanan S. Karuppagounder et al.   Science Translational Medicine

Rehabilitation Augments Hematoma Clearance and Attenuates Oxidative Injury and Ion Dyshomeostasis After Brain Hemorrhage

(2016) Michael R. Williamson et al.   STROKE

N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data

(2016) Daniel A. Monti et al.   PLoS One

Neuronal Glutathione Content and Antioxidant Capacity can be Normalized In Situ by N-acetyl Cysteine Concentrations Attained in Human Cerebrospinal Fluid

(2015) Reno C. Reyes et al.   Neurotherapeutics

Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity

(2015) Shekher Mohan et al.   NEUROTOXICOLOGY

Protection from Oxidative and Electrophilic Stress in the Gsta4-null Mouse Heart

(2013) Helen Beneš et al.   Cardiovascular Toxicology

The promise of N-acetylcysteine in neuropsychiatry

(2013) Michael Berk et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Deferoxamine Reduces Neuronal Death and Hematoma Lysis After Intracerebral Hemorrhage in Aged Rats

(2013) Tetsuhiro Hatakeyama et al.   Translational Stroke Research

Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy

(2012) Ashlee N. Higdon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy

(2011) Jone López-Erauskin et al.   ANNALS OF NEUROLOGY

Development of Neh2-Luciferase Reporter and Its Application for High Throughput Screening and Real-Time Monitoring of Nrf2 Activators

(2011) Natalya A. Smirnova et al.   CHEMISTRY & BIOLOGY

A Promoter polymorphism (rs17222919, –1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population

(2011) Dong Hwan Kim et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons

(2010) Rajiv R. Ratan et al.   JOURNAL OF NEUROCHEMISTRY

Oral N-Acetyl-Cysteine Attenuates Loss of Dopaminergic Terminals in α-Synuclein Overexpressing Mice

(2010) Joanne Clark et al.   PLoS One

PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury

(2010) T. E. North et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Intracerebral Hematoma Expansion After Aneurysmal Rupture

(2010) Charlotte J.J. van Asch et al.   STROKE

Intra-Arterial Recanalization Techniques for Patients 80 Years or Older with Acute Ischemic Stroke: Pooled Analysis from 4 Prospective Studies

(2009) A.I. Qureshi et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Methods for imaging and detecting modification of proteins by reactive lipid species

(2009) Ashlee N. Higdon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Using Enzyme Assays to Evaluate the Structure and Bioactivity of Sponge-Derived Meroterpenes

(2009) Sarah J. Robinson et al.   JOURNAL OF NATURAL PRODUCTS

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Genomic Profiles of Damage and Protection in Human Intracerebral Hemorrhage

(2008) S Thomas Carmichael et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM