Conformational Dynamics of an α-Synuclein Fibril upon Receptor Binding Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy

Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases

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Structures of α-synuclein filaments from human brains with Lewy pathology

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Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia

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Multiple system atrophy

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Reactive microglia enhance the transmission of exosomal alpha-synuclein via toll-like receptor 2

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The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3

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Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding

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Sensitivity-Enhanced Solid-State NMR Detection of Structural Differences and Unique Polymorphs in Pico- to Nanomolar Amounts of Brain-Derived and Synthetic 42-Residue Amyloid-β Fibrils

(2021) Ayesha Wickramasinghe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease

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Structure-based classification of tauopathies

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Novel tau filament fold in corticobasal degeneration

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Amyloid structure determination in RELION-3.1

(2020) Sjors H. W. Scheres   Acta Crystallographica Section D-Structural Biology

Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation

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Structures of α-synuclein filaments from multiple system atrophy

(2020) Manuel Schweighauser et al.   NATURE

A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function

(2020) Ciaran P. A. Doherty et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure

(2020) Kun Zhao et al.   Nature Communications

Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM

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α-synuclein strains that cause distinct pathologies differentially inhibit proteasome

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Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

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Amyloid structures: much more than just a cross-β fold

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Site-Specific Studies of Nucleosome Interactions by Solid-State NMR Spectroscopy

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The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

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Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

(2018) Yaowang Li et al.   CELL RESEARCH

Dynamics of the Proline-Rich C-Terminus of Huntingtin Exon-1 Fibrils

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Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease

(2018) Tae-In Kam et al.   SCIENCE

Probing the Conformationally Excited States of Membrane Proteins via 1H-Detected MAS Solid-State NMR Spectroscopy

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Cytosolic proteostasis through importing of misfolded proteins into mitochondria

(2017) Linhao Ruan et al.   NATURE

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

(2017) Wei Qiang et al.   NATURE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Fibril structure of amyloid-β(1–42) by cryo–electron microscopy

(2017) Lothar Gremer et al.   SCIENCE

Dynamic domains of amyloid fibrils can be site-specifically assigned with proton detected 3D NMR spectroscopy

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Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

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Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

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CTFFIND4: Fast and accurate defocus estimation from electron micrographs

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Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

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NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

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Broadband homonuclear correlation spectroscopy driven by combined R2nv sequences under fast magic angle spinning for NMR structural analysis of organic and biological solids

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Histone H3 and H4 N-Terminal Tails in Nucleosome Arrays at Cellular Concentrations Probed by Magic Angle Spinning NMR Spectroscopy

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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

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Relationship between amyloid-beta and the ubiquitin–proteasome system in Alzheimer’s disease

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Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

The Amyloid State of Proteins in Human Diseases

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Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

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The Dynamic Structure of Filamentous Tau

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Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

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Molecular-Level Examination of Cu2+Binding Structure for Amyloid Fibrils of 40-Residue Alzheimer’s β by Solid-State NMR Spectroscopy

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Effect of Pseudorepeat Rearrangement on α-Synuclein Misfolding, Vesicle Binding, and Micelle Binding

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High-performance solvent suppression for proton detected solid-state NMR

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