A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function

α-Synuclein misfolding and aggregation: Implications in Parkinson’s disease pathogenesis

(2019) Surabhi Mehra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

(2019) Emil Dandanell Agerschou et al.   eLife

Conformational flexibility within the nascent polypeptide–associated complex enables its interactions with structurally diverse client proteins

(2018) Esther M. Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effect of truncation on prion-like properties of α-synuclein

(2018) Makoto Terada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction

(2018) Janin Lautenschläger et al.   Nature Communications

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

(2018) Yaowang Li et al.   CELL RESEARCH

A new era for understanding amyloid structures and disease

(2018) Matthew G. Iadanza et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Cellular Environment Affects Monomeric α-Synuclein Structure

(2018) Amberley D. Stephens et al.   TRENDS IN BIOCHEMICAL SCIENCES

Amyloidogenicity at a Distance: How Distal Protein Regions Modulate Aggregation in Disease

(2017) Christina M. Lucato et al.   JOURNAL OF MOLECULAR BIOLOGY

Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth

(2017) Michael M. Wördehoff et al.   JOURNAL OF MOLECULAR BIOLOGY

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

(2017) Giuliana Fusco et al.   SCIENCE

New insights into cellular α-synuclein homeostasis in health and disease

(2016) Ulf Dettmer et al.   CURRENT OPINION IN NEUROBIOLOGY

Cellular proteostasis: degradation of misfolded proteins by lysosomes

(2016) M. P. Jackson et al.   Essays in Biochemistry

CcpNmr AnalysisAssign: a flexible platform for integrated NMR analysis

(2016) Simon P. Skinner et al.   JOURNAL OF BIOMOLECULAR NMR

X-ray Crystallographic Structure of Oligomers Formed by a Toxic β-Hairpin Derived from α-Synuclein: Trimers and Higher-Order Oligomers

(2016) Patrick J. Salveson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

(2016) Michael T. Colvin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of synaptic vesicle assembly promoted by α-synuclein

(2016) Giuliana Fusco et al.   Nature Communications

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational dynamics of α-synuclein: insights from mass spectrometry

(2015) Ashley S. Phillips et al.   ANALYST

Contact between the β1 and β2 Segments of α-Synuclein that Inhibits Amyloid Formation

(2015) Hamed Shaykhalishahi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility

(2015) Pietro Sormanni et al.   JOURNAL OF MOLECULAR BIOLOGY

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction

(2015) Johnathan Labbadia et al.   MOLECULAR CELL

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Structure of the toxic core of α-synuclein from invisible crystals

(2015) Jose A. Rodriguez et al.   NATURE

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

(2015) Serene W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unveiling transient protein-protein interactions that modulate inhibition of alpha-synuclein aggregation by beta-synuclein, a pre-synaptic protein that co-localizes with alpha-synuclein

(2015) Maria K. Janowska et al.   Scientific Reports

Sequestration of a β-Hairpin for Control of α-Synuclein Aggregation

(2014) Ewa A. Mirecka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polyglutamine Amyloid Core Boundaries and Flanking Domain Dynamics in Huntingtin Fragment Fibrils Determined by Solid-State Nuclear Magnetic Resonance

(2014) Cody L. Hoop et al.   BIOCHEMISTRY

Amyloidogenic mutations in human apolipoprotein A-I are not necessarily destabilizing - a common mechanism of apolipoprotein A-I misfolding in familial amyloidosis and atherosclerosis

(2014) Madhurima Das et al.   FEBS Journal

The N-terminal Region of Amyloid β Controls the Aggregation Rate and Fibril Stability at Low pH Through a Gain of Function Mechanism

(2014) Kristoffer Brännström et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

(2014) Giuliana Fusco et al.   Nature Communications

Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation

(2014) Luis Fonseca-Ornelas et al.   Nature Communications

Identification of Fibril-Like Tertiary Contacts in Soluble Monomeric α-Synuclein

(2013) Santiago Esteban-Martín et al.   BIOPHYSICAL JOURNAL

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

Structural Features and Domain Organization of Huntingtin Fibrils

(2012) Charles W. Bugg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of C-terminal negative charges and tyrosine residues in fibril formation of α-synuclein

(2012) Yasutaka Izawa et al.   Brain and Behavior

The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding

(2010) Tim Bartels et al.   BIOPHYSICAL JOURNAL

A Combinatorial NMR and EPR Approach for Evaluating the Structural Ensemble of Partially Folded Proteins

(2010) Jampani Nageswara Rao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Detection of Transient Interchain Interactions in the Intrinsically Disordered Protein α-Synuclein by NMR Paramagnetic Relaxation Enhancement

(2010) Kuen-Phon Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Reorganization of α-Synuclein at Low pH Observed by NMR and REMD Simulations

(2009) Kuen-Phon Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

Multiple Tight Phospholipid-Binding Modes of α-Synuclein Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   JOURNAL OF MOLECULAR BIOLOGY

Determination of the Free Energy Landscape of α-Synuclein Using Spin Label Nuclear Magnetic Resonance Measurements

(2009) Jane R. Allison et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterization of α-synuclein in an aggregation prone state

(2009) Min-Kyu Cho et al.   PROTEIN SCIENCE

The Zyggregator method for predicting protein aggregation propensities

(2008) Gian Gaetano Tartaglia et al.   CHEMICAL SOCIETY REVIEWS

Characterization of Conformational and Dynamic Properties of Natively Unfolded Human and Mouse α-Synuclein Ensembles by NMR: Implication for Aggregation

(2008) Kuen-Phon Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of membrane-bound  -synuclein from site-directed spin labeling and computational refinement

(2008) C. C. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

(2008) Tjakko J. van Ham et al.   PLoS Genetics