Aza-Residue Modulation of Cyclic d,l-α-Peptide Nanotube Assembly with Enhanced Anti-Amyloidogenic Activity

Lecanemab Gains FDA Approval for Early Alzheimer Disease

(2023) Howard D. Larkin   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Amyloid Cross-Seeding: Mechanism, Implication, and Inhibition

(2022) Sushma Subedi et al.   MOLECULES

Amyloid-Related Imaging Abnormalities With Anti-amyloid Antibodies for the Treatment of Dementia Due to Alzheimer's Disease

(2022) Charles G. Withington et al.   Frontiers in Neurology

Early diagnosis and treatment of Alzheimer’s disease by targeting toxic soluble Aβ oligomers

(2022) Maram Habashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

(2021) Phuong H. Nguyen et al.   CHEMICAL REVIEWS

Donanemab in Early Alzheimer’s Disease

(2021) Mark A. Mintun et al.   NEW ENGLAND JOURNAL OF MEDICINE

A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer’s disease with lecanemab, an anti-Aβ protofibril antibody

(2021) Chad J. Swanson et al.   Alzheimers Research & Therapy

A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease

(2021) Stephen Salloway et al.   NATURE MEDICINE

The approval of Aduhelm risks eroding public trust in Alzheimer research and the FDA

(2021) Jason Karlawish et al.   Nature Reviews Neurology

Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients With Early Alzheimer Disease

(2021) Stephen Salloway et al.   JAMA Neurology

Design and Combinatorial Development of Shield-1 Peptide Mimetics Binding to Destabilized FKBP12

(2020) Daniel Madsen et al.   ACS Combinatorial Science

Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage

(2020) Sonia Ciudad et al.   Nature Communications

Visualizing and trapping transient oligomers in amyloid assembly pathways

(2020) Emma E. Cawood et al.   BIOPHYSICAL CHEMISTRY

Biophysical processes underlying cross-seeding in amyloid aggregation and implications in amyloid pathology

(2020) Magdalena I. Ivanova et al.   BIOPHYSICAL CHEMISTRY

Native Ion Mobility-Mass Spectrometry reveals the formation of β-barrel shaped Amyloid-β hexamers in a membrane-mimicking environment

(2019) Nicklas Österlund et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of tau-derived hexapeptide aggregation and toxicity by a self-assembled cyclic d,l-α-peptide conformational inhibitor

(2018) A. Belostozky et al.   CHEMICAL COMMUNICATIONS

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

On the Basicity of Conjugated Nitrogen Heterocycles in Different Media

(2017) Märt Lõkov et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Cloaked Caged Compounds: Chemical Probes for Two-Photon Optoneurobiology

(2016) Matthew T. Richers et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-Assembled Cyclic d,l -α-Peptides as Generic Conformational Inhibitors of the α-Synuclein Aggregation and Toxicity: In Vitro and Mechanistic Studies

(2016) Marina Chemerovski-Glikman et al.   CHEMISTRY-A EUROPEAN JOURNAL

Defining the earliest pathological changes of Alzheimer's disease

(2016) James C. Vickers et al.   Current Alzheimer Research

Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis

(2016) Jinghui Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β-Protein Assembly and Alzheimer’s Disease: Dodecamers of Aβ42, but Not of Aβ40, Seed Fibril Formation

(2016) Nicholas J. Economou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid β-Protein C-Terminal Fragments: Formation of Cylindrins and β-Barrels

(2016) Thanh D. Do et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anion-Stoichiometry-Dependent Selectivity Enhancement in Ion-Paired Chiral Ligand–Palladium Complex Catalyzed Enantioselective Allylic Alkylation

(2016) Takashi Ooi et al.   SYNLETT

New Perspectives in Reducing Amyloid Aggregation and Toxicity

(2015) Marina Chemerovski-Glikman et al.   ISRAEL JOURNAL OF CHEMISTRY

Aβ42 and Aβ40: similarities and differences

(2015) Tian Qiu et al.   JOURNAL OF PEPTIDE SCIENCE

Structure-based study of antiamyloidogenic cyclic d,l-α-peptides

(2014) Marina Chemerovski-Glikman et al.   TETRAHEDRON

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

In Vitro and Mechanistic Studies of an Antiamyloidogenic Self-Assembled Cyclic d,l-α-Peptide Architecture

(2013) Michal Richman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Supramolecular Chemistry of β-Sheets

(2013) Pin-Nan Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oligomeric Intermediates in Amyloid Formation: Structure Determination and Mechanisms of Toxicity

(2012) Marcus Fändrich   JOURNAL OF MOLECULAR BIOLOGY

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

(2012) Gawain McColl et al.   Molecular Neurodegeneration

Total Synthesis of (±)-Hirsutine: Application of Phosphine-Catalyzed Imine–Allene [4 + 2] Annulation

(2012) Reymundo A. Villa et al.   ORGANIC LETTERS

Azapeptides and their therapeutic potential

(2011) Caroline Proulx et al.   Future Medicinal Chemistry

Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution

(2010) Harry Levine   PROTEIN SCIENCE

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

 -Helix targeting reduces amyloid-  peptide toxicity

(2009) C. Nerelius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preparation of Nβ-Fmoc-Protected Aza-β³-Amino Acids with Nonproteino­genic Hydrophobic Side Chains for Solid-Phase Syntheses of Pseudopeptides

(2009) Patrick Bauchat et al.   SYNTHESIS-STUTTGART

Exploiting Cross-Amyloid Interactions To Inhibit Protein Aggregation but not Function: Nanomolar Affinity Inhibition of Insulin Aggregation by an IAPP Mimic

(2008) Aleksandra Velkova et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation

(2008) Wolfgang Hoyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA