期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 1, 页码 193-197出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201609269
关键词
biologically inert; caged compounds; GABA-A receptors; optical methods; two-photon photolysis
资金
- NIH [GM053395, NS069720]
Caged neurotransmitters, in combination with focused light beams, enable precise interrogation of neuronal function, even at the level of single synapses. However, most caged transmitters are, surprisingly, severe antagonists of ionotropic gamma-aminobutyric acid (GABA) receptors. By conjugation of a large, neutral dendrimer to a caged GABA probe we introduce a cloaking technology that effectively reduces such antagonism to very low levels. Such cloaked caged compounds will enable the study of the signaling of the inhibitory neurotransmitter GABA in its natural state using two-photon uncaging microscopy for the first time.
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