TEMPORARY REMOVAL: Therapeutic opportunities for the treatment of NASH with genetically validated targets
出版年份 2023 全文链接
标题
TEMPORARY REMOVAL: Therapeutic opportunities for the treatment of NASH with genetically validated targets
作者
关键词
-
出版物
JOURNAL OF HEPATOLOGY
Volume -, Issue -, Pages -
出版商
Elsevier BV
发表日期
2023-05-17
DOI
10.1016/j.jhep.2023.05.007
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis
- (2023) Panu K. Luukkonen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hepatocyte mARC1 promotes fatty liver disease
- (2023) Lara C. Lewis et al. JHEP Reports
- Germline Mutations in CIDEB and Protection against Liver Disease
- (2022) Niek Verweij et al. NEW ENGLAND JOURNAL OF MEDICINE
- Multiomics study of nonalcoholic fatty liver disease
- (2022) Gardar Sveinbjornsson et al. NATURE GENETICS
- Microbiome-derived ethanol in nonalcoholic fatty liver disease
- (2022) Abraham S. Meijnikman et al. NATURE MEDICINE
- A metabolic associated fatty liver disease risk variant in MBOAT7 regulates toll like receptor induced outcomes
- (2022) Jawaher Alharthi et al. Nature Communications
- Exome-Wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated With Fatty Liver Disease
- (2021) Oveis Jamialahmadi et al. GASTROENTEROLOGY
- Preparing for the NASH epidemic: A call to action
- (2021) Fasiha Kanwal et al. Obesity
- Identification and Optimization of a Minor Allele-Specific Small Interfering RNA to Prevent PNPLA3 I148M-Driven Nonalcoholic Fatty Liver Disease
- (2021) Justin K. Murray et al. Nucleic Acid Therapeutics
- Convergent somatic mutations in metabolism genes in chronic liver disease
- (2021) Stanley W. K. Ng et al. NATURE
- Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease
- (2020) Stefano Romeo et al. Cell Metabolism
- Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis
- (2020) Björn Carlsson et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover
- (2020) Yuki Tanaka et al. GUT
- Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort
- (2020) Quentin M. Anstee et al. JOURNAL OF HEPATOLOGY
- A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
- (2020) Connor A. Emdin et al. PLoS Genetics
- Hsd17b13 Deficiency Does not Protect Mice From Obesogenic Diet Injury
- (2020) Yanling Ma et al. HEPATOLOGY
- A common variant in PNPLA3 is associated with age at diagnosis of NAFLD in patients from a multi-ethnic biobank
- (2020) Ryan W. Walker et al. JOURNAL OF HEPATOLOGY
- MAFLD vs NAFLD: Let the contest begin!
- (2020) Cristiana Bianco et al. LIVER INTERNATIONAL
- Identification of a Metabolic, Transcriptomic, and Molecular Signature of Patatin‐Like Phospholipase Domain Containing 3–Mediated Acceleration of Steatohepatitis
- (2020) Bubu A. Banini et al. HEPATOLOGY
- Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores
- (2020) Cristiana Bianco et al. JOURNAL OF HEPATOLOGY
- PNPLA3, CGI-58, and Inhibition of Hepatic Triglyceride Hydrolysis in Mice
- (2019) Yang Wang et al. HEPATOLOGY
- Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis
- (2019) Soumik BasuRay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice
- (2019) Daniel Lindén et al. Molecular Metabolism
- MBOAT7 is anchored to endomembranes by six transmembrane domains
- (2019) Andrea Caddeo et al. JOURNAL OF STRUCTURAL BIOLOGY
- Pharmacological lipid-modification therapies for prevention of ischaemic heart disease: current and future options
- (2019) Kausik K Ray et al. LANCET
- Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae
- (2019) Jing Yuan et al. Cell Metabolism
- PNPLA3 I148M and liver fat and fibrosis scores predict liver disease mortality in the United States population
- (2019) Aynur Unalp‐Arida et al. HEPATOLOGY
- Detoxification of Trimethylamine N-Oxide by the Mitochondrial Amidoxime Reducing Component mARC
- (2018) Jennifer Schneider et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Hydroxysteroid (17β) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice
- (2018) Marion Adam et al. FASEB JOURNAL
- A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease
- (2018) Noura S. Abul-Husn et al. NEW ENGLAND JOURNAL OF MEDICINE
- HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease
- (2018) Yanling Ma et al. HEPATOLOGY
- HSD17B13 and Chronic Liver Disease in Blacks and Hispanics
- (2018) Julia Kozlitina et al. NEW ENGLAND JOURNAL OF MEDICINE
- Phenome-wide association studies across large population cohorts support drug target validation
- (2018) Dorothée Diogo et al. Nature Communications
- Liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease: Mendelian randomization and meta-analysis of 279 013 individuals
- (2017) Bo Kobberø Lauridsen et al. EUROPEAN HEART JOURNAL
- PNPLA3, TM6SF2, and MBOAT7 Genotypes and Coronary Artery Disease
- (2017) Nynke Simons et al. GASTROENTEROLOGY
- The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation
- (2017) Soumik BasuRay et al. HEPATOLOGY
- Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver
- (2017) P. Dongiovanni et al. JOURNAL OF INTERNAL MEDICINE
- Serum apoB levels independently predict the development of non-alcoholic fatty liver disease: A 7-year prospective study
- (2017) Jinghua Wang et al. LIVER INTERNATIONAL
- Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci
- (2017) Stefan Stender et al. NATURE GENETICS
- The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent
- (2016) Rosellina Margherita Mancina et al. GASTROENTEROLOGY
- The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage
- (2016) Benedetta Donati et al. HEPATOLOGY
- Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes
- (2016) Wenyi Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PNPLA3 gene in liver diseases
- (2016) Eric Trépo et al. JOURNAL OF HEPATOLOGY
- A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
- (2015) Stephan Buch et al. NATURE GENETICS
- Pnpla3I148Mknockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
- (2014) Eriks Smagris et al. HEPATOLOGY
- PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells
- (2014) Carlo Pirazzi et al. HUMAN MOLECULAR GENETICS
- Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma
- (2014) Y.-L. Liu et al. JOURNAL OF HEPATOLOGY
- Comparative proteomic study reveals 17 -HSD13 as a pathogenic protein in nonalcoholic fatty liver disease
- (2014) W. Su et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Mitochondrial Amidoxime-reducing Component (mARC1) Is a Novel Signal-anchored Protein of the Outer Mitochondrial Membrane
- (2012) Julian M. Klein et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis
- (2012) John Zhong Li et al. JOURNAL OF CLINICAL INVESTIGATION
- Paradoxical Lower Serum Triglyceride Levels and Higher Type 2 Diabetes Mellitus Susceptibility in Obese Individuals with the PNPLA3 148M Variant
- (2012) Colin N. A. Palmer et al. PLoS One
- Mammalian Triacylglycerol Metabolism: Synthesis, Lipolysis, and Signaling
- (2011) Rosalind A. Coleman et al. CHEMICAL REVIEWS
- Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
- (2010) Weiqin Chen et al. HEPATOLOGY
- Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B
- (2009) Jing Ye et al. Cell Metabolism
- A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis
- (2009) Shaoqing He et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The role of mitochondrial glycerol-3-phosphate acyltransferase-1 in regulating lipid and glucose homeostasis in high-fat diet fed mice
- (2008) Misak Yazdi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
- (2008) Stefano Romeo et al. NATURE GENETICS
- Caenorhabditis elegans mboa-7, a Member of the MBOAT Family, Is Required for Selective Incorporation of Polyunsaturated Fatty Acids into Phosphatidylinositol
- (2007) Hyeon-Cheol Lee et al. MOLECULAR BIOLOGY OF THE CELL
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