Convergent somatic mutations in metabolism genes in chronic liver disease

Molecular characterization of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis

(2021) Roser Pinyol et al.   JOURNAL OF HEPATOLOGY

Alcohol effects on hepatic lipid metabolism

(2020) Sookyoung Jeon et al.   JOURNAL OF LIPID RESEARCH

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

(2020) Esther Rheinbay et al.   NATURE

Tobacco smoking and somatic mutations in human bronchial epithelium

(2020) Kenichi Yoshida et al.   NATURE

The repertoire of mutational signatures in human cancer

(2020) Ludmil B. Alexandrov et al.   NATURE

Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver

(2020) K. Brazhnik et al.   Science Advances

Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing

(2020) Peter Ellis et al.   Nature Protocols

Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis

(2019) Soo Ki Kim et al.   JOURNAL OF GASTROENTEROLOGY

Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease

(2019) Min Zhu et al.   CELL

AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins

(2019) Maria Saline et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

(2019) Keren Yizhak et al.   SCIENCE

SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events

(2019) Erik N. Bergstrom et al.   BMC GENOMICS

Somatic mutations and clonal dynamics in healthy and cirrhotic human liver

(2019) Simon F. Brunner et al.   NATURE

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

(2018) James H. R. Farmery et al.   Scientific Reports

Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma

(2017) Sara Torrecilla et al.   JOURNAL OF HEPATOLOGY

Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis

(2017) Eric Letouzé et al.   Nature Communications

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

NOTCH1 mediates a switch between two distinct secretomes during senescence

(2016) Matthew Hoare et al.   NATURE CELL BIOLOGY

Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

(2016) Akihiro Fujimoto et al.   NATURE GENETICS

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix

(2015) David Barneda et al.   eLife

MCMC Methods for Multi-Response Generalized Linear Mixed Models: TheMCMCglmmRPackage

(2015) Jarrod D. Hadfield   Journal of Statistical Software

Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis

(2014) Jean Charles Nault et al.   HEPATOLOGY

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

(2014) Yasushi Totoki et al.   NATURE GENETICS

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Glycerol-3-phosphate Acyltransferase (GPAT)-1, but Not GPAT4, Incorporates Newly Synthesized Fatty Acids into Triacylglycerol and Diminishes Fatty Acid Oxidation

(2013) Angela A. Wendel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes

(2013) Zhiqi Sun et al.   Nature Communications

The Life History of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

(2012) Akihiro Fujimoto et al.   NATURE GENETICS

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

(2012) Cécile Guichard et al.   NATURE GENETICS

PERT: A Method for Expression Deconvolution of Human Blood Samples from Varied Microenvironmental and Developmental Conditions

(2012) Wenlian Qiao et al.   PLoS Computational Biology

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study

(2011) Robin D. Clugston et al.   JOURNAL OF LIPID RESEARCH

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing

(2008) Peter J Campbell et al.   NATURE GENETICS