Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis
出版年份 2020 全文链接
标题
Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis
作者
关键词
-
出版物
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Volume 51, Issue 12, Pages 1305-1320
出版商
Wiley
发表日期
2020-05-08
DOI
10.1111/apt.15738
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- PNPLA3 Genotype and Risk of Liver and All‐Cause Mortality
- (2020) Stefan Stender et al. HEPATOLOGY
- Genetics of Nonalcoholic Fatty Liver Disease: a 2018 Update.
- (2019) Luca VC Valenti et al. CURRENT PHARMACEUTICAL DESIGN
- Meta-analysis of the association between MBOAT7 rs641738, TM6SF2 rs58542926 and nonalcoholic fatty liver disease susceptibility
- (2019) Yan Xia et al. Clinics and Research in Hepatology and Gastroenterology
- Genetics of Nonalcoholic Fatty Liver Disease: From Pathogenesis to Therapeutics
- (2019) Silvia Sookoian et al. SEMINARS IN LIVER DISEASE
- Does nonalcoholic fatty liver disease cause cardiovascular disease? Current knowledge and gaps
- (2019) Raul D. Santos et al. ATHEROSCLEROSIS
- A Structured Literature Review of the Epidemiology and Disease Burden of Non-Alcoholic Steatohepatitis (NASH)
- (2019) Manca Povsic et al. ADVANCES IN THERAPY
- Polygenic risk scores in coronary artery disease
- (2019) Abhiram S. Rao et al. CURRENT OPINION IN CARDIOLOGY
- Inherited nonalcoholic fatty liver disease and dyslipidemia due to monoallelic ABHD5 mutations
- (2019) Leila Youssefian et al. JOURNAL OF HEPATOLOGY
- Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis
- (2019) Soumik BasuRay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice
- (2019) Daniel Lindén et al. Molecular Metabolism
- High Risk of Fatty Liver Disease Amplifies the Alanine Transaminase‐Lowering effect of a HSD 17B13 Variant
- (2019) Helene Gellert‐Kristensen et al. HEPATOLOGY
- MBOAT7 is anchored to endomembranes by six transmembrane domains
- (2019) Andrea Caddeo et al. JOURNAL OF STRUCTURAL BIOLOGY
- The roles of transmembrane 6 superfamily member 2 rs58542926 polymorphism in chronic liver disease: A meta‐analysis of 24,147 subjects
- (2019) Xinpei Chen et al. Molecular Genetics & Genomic Medicine
- Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients with Non-alcoholic Fatty Liver Disease
- (2019) Stefania Grimaudo et al. Clinical Gastroenterology and Hepatology
- Lean NAFLD : A Distinct Entity Shaped by Differential Metabolic Adaptation
- (2019) Fei Chen et al. HEPATOLOGY
- What lipodystrophies teach us about the metabolic syndrome
- (2019) Jake P. Mann et al. JOURNAL OF CLINICAL INVESTIGATION
- PNPLA3 I148M and liver fat and fibrosis scores predict liver disease mortality in the United States population
- (2019) Aynur Unalp‐Arida et al. HEPATOLOGY
- The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids
- (2019) Sebastian Prill et al. Scientific Reports
- Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis
- (2019) Bishuang Cai et al. Cell Metabolism
- Nonalcoholic Steatohepatitis (NASH) and Hepatic Fibrosis: Emerging Therapies
- (2018) Julia Wattacheril et al. Annual Review of Pharmacology and Toxicology
- The role of PNPLA3 in health and disease
- (2018) Piero Pingitore et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- The Genetics of Pediatric Nonalcoholic Fatty Liver Disease
- (2018) Nidhi P. Goyal et al. Clinics in Liver Disease
- Effects of dapagliflozin and n-3 carboxylic acids on non-alcoholic fatty liver disease in people with type 2 diabetes: a double-blind randomised placebo-controlled study
- (2018) Jan W. Eriksson et al. DIABETOLOGIA
- NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects
- (2018) Eeva Sliz et al. HUMAN MOLECULAR GENETICS
- Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets
- (2018) Matthew A. Mitsche et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genetics and epigenetics of NAFLD and NASH: Clinical impact
- (2018) Mohammed Eslam et al. JOURNAL OF HEPATOLOGY
- Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030
- (2018) Chris Estes et al. JOURNAL OF HEPATOLOGY
- Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
- (2018) Anubha Mahajan et al. NATURE GENETICS
- A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease
- (2018) Noura S. Abul-Husn et al. NEW ENGLAND JOURNAL OF MEDICINE
- Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers
- (2018) Takahisa Kawaguchi et al. PLoS One
- Lack of evidence supporting a role of TMC4-rs641738 missense variant—MBOAT7- intergenic downstream variant—in the Susceptibility to Nonalcoholic Fatty Liver Disease
- (2018) Silvia Sookoian et al. Scientific Reports
- Nonalcoholic fatty liver disease burden – Saudi Arabia and United Arab Emirates, 2017–2030
- (2018) Homie Razavi et al. Saudi Journal of Gastroenterology
- PNPLA3 variant M148 causes resistance to starvation-mediated lipid droplet autophagy in human hepatocytes
- (2018) Florentina Negoita et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease: A double-blind, randomized, placebo-controlled study
- (2018) Jan Oscarsson et al. Journal of Clinical Lipidology
- Dissociation of Fatty Liver and Insulin Resistance in I148M PNPLA3 Carriers: Differences in Diacylglycerol (DAG) FA18:1 Lipid Species as a Possible Explanation
- (2018) Andras Franko et al. Nutrients
- Complete Resolution of Nonalcoholic Fatty Liver Disease After Bariatric Surgery: A Systematic Review and Meta-Analysis
- (2018) Yung Lee et al. Clinical Gastroenterology and Hepatology
- HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease
- (2018) Yanling Ma et al. HEPATOLOGY
- Splice variant rs72613567 prevents worst histologic outcomes in patients with nonalcoholic fatty liver disease
- (2018) Carlos J. Pirola et al. JOURNAL OF LIPID RESEARCH
- HSD17B13 and Chronic Liver Disease in Blacks and Hispanics
- (2018) Julia Kozlitina et al. NEW ENGLAND JOURNAL OF MEDICINE
- Phenome-wide association studies across large population cohorts support drug target validation
- (2018) Dorothée Diogo et al. Nature Communications
- Liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease: Mendelian randomization and meta-analysis of 279 013 individuals
- (2017) Bo Kobberø Lauridsen et al. EUROPEAN HEART JOURNAL
- Changes in the Prevalence of Hepatitis C Virus Infection, Nonalcoholic Steatohepatitis, and Alcoholic Liver Disease Among Patients With Cirrhosis or Liver Failure on the Waitlist for Liver Transplantation
- (2017) David Goldberg et al. GASTROENTEROLOGY
- The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells
- (2017) Francesca Virginia Bruschi et al. HEPATOLOGY
- The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation
- (2017) Soumik BasuRay et al. HEPATOLOGY
- Mutant PNPLA3 I148M protein as pharmacological target for liver disease
- (2017) Luca Valenti et al. HEPATOLOGY
- Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis
- (2017) Cyrielle Caussy et al. JOURNAL OF CLINICAL INVESTIGATION
- Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver
- (2017) P. Dongiovanni et al. JOURNAL OF INTERNAL MEDICINE
- Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci
- (2017) Stefan Stender et al. NATURE GENETICS
- Exome-wide association study of plasma lipids in >300,000 individuals
- (2017) Dajiang J Liu et al. NATURE GENETICS
- Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
- (2017) Zobair Younossi et al. Nature Reviews Gastroenterology & Hepatology
- The PNPLA3 I148M variant is associated with transaminase elevations in type 2 diabetes patients treated with basal insulin peglispro
- (2017) S Pillai et al. PHARMACOGENOMICS JOURNAL
- MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals
- (2017) Benedetta Donati et al. Scientific Reports
- Reduction of Caloric Intake Might Override the Prosteatotic Effects of the PNPLA3 p.I148M and TM6SF2 p.E167K Variants in Patients with Fatty Liver: Ultrasound-Based Prospective Study
- (2016) Marcin Krawczyk et al. DIGESTION
- The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent
- (2016) Rosellina Margherita Mancina et al. GASTROENTEROLOGY
- Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes
- (2016) Zobair M. Younossi et al. HEPATOLOGY
- The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage
- (2016) Benedetta Donati et al. HEPATOLOGY
- EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
- (2016) JOURNAL OF HEPATOLOGY
- Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease
- (2016) Panu K. Luukkonen et al. JOURNAL OF HEPATOLOGY
- The genetic architecture of type 2 diabetes
- (2016) Christian Fuchsberger et al. NATURE
- Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
- (2016) Luca A Lotta et al. NATURE GENETICS
- Drug developers delve into the cell's trash-disposal machinery
- (2016) Kelly Rae Chi NATURE REVIEWS DRUG DISCOVERY
- PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery
- (2016) Marcin Krawczyk et al. Surgery for Obesity and Related Diseases
- Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies
- (2015) Siddharth Singh et al. Clinical Gastroenterology and Hepatology
- Glucokinase regulatory protein
- (2015) Anne Raimondo et al. CURRENT OPINION IN LIPIDOLOGY
- Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study
- (2015) Rohit Loomba et al. GASTROENTEROLOGY
- Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease
- (2015) Paola Dongiovanni et al. HEPATOLOGY
- Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: Findings and recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint Workshop
- (2015) Arun J. Sanyal et al. HEPATOLOGY
- Nonalcoholic Fatty Liver Disease
- (2015) Mary E. Rinella JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- The Genetic Variant I148M inPNPLA3Is Associated With Increased Hepatic Retinyl-Palmitate Storage in Humans
- (2015) Marketa Kovarova et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Paradoxical Dissociation Between Hepatic Fat Content and De Novo Lipogenesis Due toPNPLA3Sequence Variant
- (2015) Rosellina M. Mancina et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management
- (2015) Stuart McPherson et al. JOURNAL OF HEPATOLOGY
- Statin use and non-alcoholic steatohepatitis in at risk individuals
- (2015) Paola Dongiovanni et al. JOURNAL OF HEPATOLOGY
- HCC and liver disease risks in homozygous PNPLA3 p.I148M carriers approach monogenic inheritance
- (2015) Marcin Krawczyk et al. JOURNAL OF HEPATOLOGY
- Treating liver fat and serum triglyceride levels in NAFLD, effects of PNPLA3 and TM6SF2 genotypes: Results from the WELCOME trial
- (2015) Eleonora Scorletti et al. JOURNAL OF HEPATOLOGY
- PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity
- (2015) Alison Mondul et al. JOURNAL OF NUTRITION
- A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
- (2015) Stephan Buch et al. NATURE GENETICS
- Treatment of Nonalcoholic Steatohepatitis in Adults: Present and Future
- (2015) S. Gitto et al. Gastroenterology Research and Practice
- Association Between Patatin-Like Phospholipase Domain Containing 3 Gene (PNPLA3) Polymorphisms and Nonalcoholic Fatty Liver Disease: A HuGE Review and Meta-Analysis
- (2015) Renfan Xu et al. Scientific Reports
- The Effect of PNPLA3 on Fibrosis Progression and Development of Hepatocellular Carcinoma: A Meta-analysis
- (2014) Amit G Singal et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans
- (2014) Andreas Peter et al. DIABETOLOGIA
- Pnpla3I148Mknockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
- (2014) Eriks Smagris et al. HEPATOLOGY
- PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells
- (2014) Carlo Pirazzi et al. HUMAN MOLECULAR GENETICS
- PNPLA3gene polymorphism and response to lifestyle modification in patients with nonalcoholic fatty liver disease
- (2014) Jiayun Shen et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma
- (2014) Y.-L. Liu et al. JOURNAL OF HEPATOLOGY
- PNPLA3 mediates hepatocyte triacylglycerol remodeling
- (2014) Hanna Ruhanen et al. JOURNAL OF LIPID RESEARCH
- Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
- (2014) Julia Kozlitina et al. NATURE GENETICS
- Comparative proteomic study reveals 17 -HSD13 as a pathogenic protein in nonalcoholic fatty liver disease
- (2014) W. Su et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Non-alcoholic fatty liver disease: What has changed in the treatment since the beginning?
- (2014) Bülent Baran WORLD JOURNAL OF GASTROENTEROLOGY
- TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
- (2014) Yang-Lin Liu et al. Nature Communications
- Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function
- (2013) Piero Pingitore et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Circulating Triacylglycerol Signatures in Nonalcoholic Fatty Liver Disease Associated With the I148M Variant in PNPLA3 and With Obesity
- (2013) J. Hyysalo et al. DIABETES
- Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan
- (2013) Takuya Kitamoto et al. HUMAN GENETICS
- Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: an interaction study with adiponutrin gene
- (2013) Hwa-Li Tan et al. JOURNAL OF GASTROENTEROLOGY
- The I148M Variant of PNPLA3 Reduces the Response to Docosahexaenoic Acid in Children with Non-Alcoholic Fatty Liver Disease
- (2013) Valerio Nobili et al. JOURNAL OF MEDICINAL FOOD
- Evolution of glucose utilization: Glucokinase and glucokinase regulator protein
- (2013) David M. Irwin et al. MOLECULAR PHYLOGENETICS AND EVOLUTION
- Molecular dynamics simulation of PNPLA3 I148M polymorphism reveals reduced substrate access to the catalytic cavity
- (2013) Yong-Ning Xin et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- PNPLA3 I148M polymorphism and progressive liver disease
- (2013) Paola Dongiovanni WORLD JOURNAL OF GASTROENTEROLOGY
- Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans
- (2012) Ksenia Sevastianova et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis
- (2012) Julia Perttilä et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Adiponutrin Functions as a Nutritionally Regulated Lysophosphatidic Acid Acyltransferase
- (2012) Manju Kumari et al. Cell Metabolism
- PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals
- (2012) Maria Antonella Burza et al. DIGESTIVE AND LIVER DISEASE
- The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
- (2012) Naga Chalasani et al. HEPATOLOGY
- Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats
- (2012) Naoki Kumashiro et al. HEPATOLOGY
- PNPLA3 gene-by-visceral adipose tissue volume interaction and the pathogenesis of fatty liver disease: The NHLBI Family Heart Study
- (2012) M Graff et al. INTERNATIONAL JOURNAL OF OBESITY
- Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis
- (2012) John Zhong Li et al. JOURNAL OF CLINICAL INVESTIGATION
- Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro
- (2012) Carlo Pirazzi et al. JOURNAL OF HEPATOLOGY
- Hepatic Fat Accumulation Is Modulated by the Interaction between the rs738409 Variant in the PNPLA3 Gene and the Dietary Omega6/Omega3 PUFA Intake
- (2012) Nicola Santoro et al. PLoS One
- Paradoxical Lower Serum Triglyceride Levels and Higher Type 2 Diabetes Mellitus Susceptibility in Obese Individuals with the PNPLA3 148M Variant
- (2012) Colin N. A. Palmer et al. PLoS One
- Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
- (2011) G. Vernon et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
- (2011) Nicola Santoro et al. HEPATOLOGY
- Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
- (2011) Silvia Sookoian et al. HEPATOLOGY
- Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease
- (2011) Yongcheng Huang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
- (2011) John C Chambers et al. NATURE GENETICS
- The Association of PNPLA3 Variants with Liver Enzymes in Childhood Obesity Is Driven by the Interaction with Abdominal Fat
- (2011) Emanuele Miraglia del Giudice et al. PLoS One
- Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
- (2011) Elizabeth K. Speliotes et al. PLoS Genetics
- Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study
- (2010) Christopher D. Williams et al. GASTROENTEROLOGY
- Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
- (2010) Weiqin Chen et al. HEPATOLOGY
- PNPLA3variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
- (2010) Elizabeth K. Speliotes et al. HEPATOLOGY
- Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
- (2010) Luca Valenti et al. HEPATOLOGY
- The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life
- (2010) Stefano Romeo et al. JOURNAL OF HEPATOLOGY
- Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytes
- (2010) Céline Dubuquoy et al. JOURNAL OF HEPATOLOGY
- Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome
- (2010) Mahesh K. Basantani et al. JOURNAL OF LIPID RESEARCH
- A feed-forward loop amplifies nutritional regulation of PNPLA3
- (2010) Yongcheng Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene
- (2009) K. Kantartzis et al. DIABETES
- Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent
- (2009) S Romeo et al. INTERNATIONAL JOURNAL OF OBESITY
- A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis
- (2009) Shaoqing He et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status
- (2009) Menno Hoekstra et al. JOURNAL OF HEPATOLOGY
- Higher liver fat content among Japanese in Japan compared with non-Hispanic whites in the United States
- (2009) Koichiro Azuma et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Finding the missing heritability of complex diseases
- (2009) Teri A. Manolio et al. NATURE
- Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions
- (2008) Petra C. Kienesberger et al. JOURNAL OF LIPID RESEARCH
- Integrated view on 17beta-hydroxysteroid dehydrogenases
- (2008) Gabriele Moeller et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
- (2008) Stefano Romeo et al. NATURE GENETICS
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