TGF‐β‐induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease

The Role of Transforming Growth Factor-β Signaling in Myxomatous Mitral Valve Degeneration

(2022) Qiyu Tang et al.   Frontiers in Cardiovascular Medicine

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

(2021) Ruchi Kumari et al.   Frontiers in Cell and Developmental Biology

Role of PI3K/Akt signaling pathway in cardiac fibrosis

(2021) Wuming Qin et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

PI3K inhibitors are finally coming of age

(2021) Bart Vanhaesebroeck et al.   NATURE REVIEWS DRUG DISCOVERY

Characterization of the spontaneous degenerative mitral valve disease in FVB mice

(2021) Estelle Ayme-Dietrich et al.   PLoS One

Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination

(2021) Vahan Martirosian et al.   Cell Reports

Evaluation of Short-Chain Antimicrobial Peptides With Combined Antimicrobial and Anti-inflammatory Bioactivities for the Treatment of Zoonotic Skin Pathogens From Canines

(2021) Qiyu Tang et al.   Frontiers in Microbiology

Akt acts as a switch for GPCR transactivation of the TGF‐β receptor type 1

(2021) Raafat Mohamed et al.   FEBS Journal

Deficiency of Circulating Monocytes Ameliorates the Progression of Myxomatous Valve Degeneration in Marfan Syndrome

(2020) Andrew J. Kim et al.   CIRCULATION

Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer

(2020) Benjamin D. Hopkins et al.   Nature Reviews Endocrinology

Comparative pathology of human and canine myxomatous mitral valve degeneration: 5HT and TGF-β mechanisms

(2020) Mark A. Oyama et al.   CARDIOVASCULAR PATHOLOGY

Macrophage lineages in heart valve development and disease

(2020) Andrew J Kim et al.   CARDIOVASCULAR RESEARCH

Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway

(2020) Ziying Chen et al.   CARDIOVASCULAR RESEARCH

Disease Severity-Associated Gene Expression in Canine Myxomatous Mitral Valve Disease Is Dominated by TGFβ Signaling

(2020) Greg R. Markby et al.   Frontiers in Genetics

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction

(2019) Y. Kakiuchi et al.   OSTEOARTHRITIS AND CARTILAGE

Lipopolysaccharide promotes lung fibroblast proliferation through autophagy inhibition via activation of the PI3K-Akt-mTOR pathway

(2019) Tingting Xie et al.   LABORATORY INVESTIGATION

Transforming growth factor–β (TGF-β)–induced up-regulation of TGF-β receptors at the cell surface amplifies the TGF-β response

(2019) Dana Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol suppresses the myofibroblastic phenotype and fibrosis formation in kidneys via proliferation‐related signalling pathways

(2019) Xing Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Evaluation of canine 2D cell cultures as models of myxomatous mitral valve degeneration

(2019) Karen Tan et al.   PLoS One

Pleiotropic Effects of mTOR and Autophagy During Development and Aging

(2019) Kathrin Schmeisser et al.   Frontiers in Cell and Developmental Biology

Survival of activated myofibroblasts in canine myxomatous mitral valve disease and the role of apoptosis

(2019) Rachel R. Blake et al.   RESEARCH IN VETERINARY SCIENCE

Filamin-A as a Balance between Erk/Smad Activities During Cardiac Valve Development

(2018) Katelynn Toomer et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases

(2018) Jun Ren et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Myxomatous Degeneration of the Canine Mitral Valve: From Gross Changes to Molecular Events

(2017) G. Markby et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction

(2017) M. Ito et al.   OSTEOARTHRITIS AND CARTILAGE

Mitral Annular Disjunction

(2017) Maurice Enriquez-Sarano   JACC-Cardiovascular Imaging

Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification

(2017) Arkady Rutkovskiy et al.   Journal of the American Heart Association

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

(2017) Viktor I. Korolchuk et al.   EBioMedicine

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease

(2016) Alexia Hulin et al.   CARDIOVASCULAR RESEARCH

Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

(2016) Jason S. L. Yu et al.   DEVELOPMENT

Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF

(2016) Paul F Mercer et al.   THORAX

Non-Smad Signaling Pathways of the TGF-β Family

(2016) Ying E. Zhang   Cold Spring Harbor Perspectives in Biology

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion

(2015) Caroline Mauvezin et al.   Autophagy

TGF-beta1 pathway activation and adherens junction molecular pattern in nonsyndromic mitral valve prolapse

(2015) Stefania Rizzo et al.   CARDIOVASCULAR PATHOLOGY

Nonbiased Molecular Screening Identifies Novel Molecular Regulators of Fibrogenic and Proliferative Signaling in Myxomatous Mitral Valve DiseaseCLINICAL PERSPECTIVE

(2015) Nassir M. Thalji et al.   Circulation-Cardiovascular Genetics

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitral valve disease—morphology and mechanisms

(2015) Robert A. Levine et al.   Nature Reviews Cardiology

Culture and characterisation of canine mitral valve interstitial and endothelial cells

(2015) M.-M. Liu et al.   VETERINARY JOURNAL

Developmental pathways and endothelial to mesenchymal transition in canine myxomatous mitral valve disease

(2015) Chi-Chien Lu et al.   VETERINARY JOURNAL

Nonbiased Molecular Screening Identifies Novel Molecular Regulators of Fibrogenic and Proliferative Signaling in Myxomatous Mitral Valve DiseaseCLINICAL PERSPECTIVE

(2015) Nassir M. Thalji et al.   Circulation-Cardiovascular Genetics

Modulation of Human Valve Interstitial Cell Phenotype and Function Using a Fibroblast Growth Factor 2 Formulation

(2015) Najma Latif et al.   PLoS One

Suppression of Feedback Loops Mediated by PI3K/mTOR Induces Multiple Overactivation of Compensatory Pathways: An Unintended Consequence Leading to Drug Resistance

(2014) E. Rozengurt et al.   MOLECULAR CANCER THERAPEUTICS

Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome

(2014) Ronald V. Lacro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapamycin Reverses Pulmonary Artery Smooth Muscle Cell Proliferation in Pulmonary Hypertension

(2013) Amal Houssaini et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

TGF-β signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves

(2013) Michael A. Hagler et al.   CARDIOVASCULAR RESEARCH

Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer

(2013) Long Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

Modulation of Transforming Growth Factor-  Signaling and Extracellular Matrix Production in Myxomatous Mitral Valves by Angiotensin II Receptor Blockers

(2012) A. Geirsson et al.   CIRCULATION

Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death

(2012) H. Jo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Historical review, epidemiology and natural history of degenerative mitral valve disease

(2012) Michele Borgarelli et al.   Journal of Veterinary Cardiology

Myxomatous mitral valve disease in dogs: Does size matter?

(2012) Heidi G. Parker et al.   Journal of Veterinary Cardiology

Pathology of myxomatous mitral valve disease in the dog

(2012) Philip R. Fox   Journal of Veterinary Cardiology

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

(2011) M V Astle et al.   ONCOGENE