期刊
TOXICOLOGY LETTERS
卷 232, 期 2, 页码 349-355出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2014.11.011
关键词
Glioma; Methionine; Cystine/cysteine; ROS; Autophagy
类别
资金
- First Affiliated Hospital of Harbin Medical University Foundation [2014B05]
- National Natural Science Foundation of China [81402061, 81272788]
- Heilongjiang overseas fund [LC2011C21]
Cancer cells are highly dependent on methionine and cystine (Met-Cys) for survival and proliferation. However, the molecular mechanism is not fully clear. The present study is to investigate the effects of Met-Cys deprivation on glioma cells proliferation. The results showed that Met-Cys double deprivation had synergistic action on elevating ROS level, decreased GSH level and inhibition of glioma cell proliferation. Moreover, both of them deprivation triggered autophagy of glioma cells both in vitro and in vivo. Importantly, Met-Cys double restriction diet inhibited growth of glioma. These results provided a new regulation mechanism of Met-Cys metabolism on affecting glioma cell proliferation, suggesting that targeting Met-Cys metabolism may be a potential strategy for glioma therapy. (c) 2014 Elsevier Ireland Ltd. All rights reserved.
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