Current Promising Strategies against Antibiotic-Resistant Bacterial Infections

Engineered human antibodies for the opsonization and killing of Staphylococcus aureus

(2022) Xinhai Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensitizing Staphylococcus aureus to antibacterial agents by decoding and blocking the lipid flippase MprF

(2022) Christoph J Slavetinsky et al.   eLife

Aptamer-Targeted Drug Delivery for Staphylococcus aureus Biofilm

(2022) Pernille Ommen et al.   Frontiers in Cellular and Infection Microbiology

Direct Lytic Agents: Novel, Rapidly Acting Potential Antimicrobial Treatment Modalities for Systemic Use in the Era of Rising Antibiotic Resistance

(2022) Raymond Schuch et al.   Frontiers in Microbiology

Old and Modern Antibiotic Structures with Potential for Today’s Infections

(2022) David Newman   ADMET and DMPK

Non-protective immune imprint underlies failure of Staphylococcus aureus IsdB vaccine

(2022) Chih-Ming Tsai et al.   Cell Host & Microbe

Teixobactin kills bacteria by a two-pronged attack on the cell envelope

(2022) Rhythm Shukla et al.   NATURE

A Biological Signature for the Inhibition of Outer Membrane Lipoprotein Biogenesis

(2022) Kelly M. Lehman et al.   mBio

Impact of the Gram-Negative-Selective Inhibitor MAC13243 on In Vitro Simulated Gut Microbiota

(2022) Frida Svanberg Frisinger et al.   Pharmaceuticals

Progress and prospects of nanomaterials against resistant bacteria

(2022) Jian He et al.   JOURNAL OF CONTROLLED RELEASE

Detection of Klebsiella pneumoniae human gut carriage: a comparison of culture, qPCR, and whole metagenomic sequencing methods

(2022) Kenneth Lindstedt et al.   Gut Microbes

Thanatin: An Emerging Host Defense Antimicrobial Peptide with Multiple Modes of Action

(2021) Rachita Dash et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nonimmune antibody interactions of Group A Streptococcus M and M-like proteins

(2021) Jori O. Mills et al.   PLoS Pathogens

Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease

(2021) Xin Tan et al.   Frontiers in Cellular and Infection Microbiology

Phage φAB6-Borne Depolymerase Combats Acinetobacter baumannii Biofilm Formation and Infection

(2021) Md. Shahed-Al-Mahmud et al.   Antibiotics-Basel

Novel Strategies to Combat Bacterial Biofilms

(2021) Fatemeh Hemmati et al.   MOLECULAR BIOTECHNOLOGY

Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance

(2021) Magda Ferreira et al.   MOLECULES

Antibody-based cancer therapy

(2021) Rebecca S. Goydel et al.   ONCOGENE

Reactive Oxygen Species-Related Ceftazidime Resistance Is Caused by the Pyruvate Cycle Perturbation and Reverted by Fe3 + in Edwardsiella tarda

(2021) Jingzhou Ye et al.   Frontiers in Microbiology

Diversity of Functionally Distinct Clonal Sets of Human Conventional Memory B Cells That Bind Staphylococcal Protein A

(2021) Emily E. Radke et al.   Frontiers in Immunology

Bacterial Outer Membrane‐Coated Mesoporous Silica Nanoparticles for Targeted Delivery of Antibiotic Rifampicin against Gram‐Negative Bacterial Infection In Vivo

(2021) Shuang Wu et al.   ADVANCED FUNCTIONAL MATERIALS

Effect of antibiotic stewardship interventions in primary care on antimicrobial resistance of Escherichia coli bacteraemia in England (2013–18): a quasi-experimental, ecological, data linkage study

(2021) Shirin Aliabadi et al.   LANCET INFECTIOUS DISEASES

Can financial rewards for stewardship in primary care curb antibiotic resistance?

(2021) Alexander Lawandi et al.   LANCET INFECTIOUS DISEASES

A protein A based Staphylococcus aureus vaccine with improved safety

(2021) Miaomiao Shi et al.   VACCINE

Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria

(2021) Xian-liang Zhao et al.   Science Translational Medicine

Nanosilver Targets the Bacterial Cell Envelope: The Link with Generation of Reactive Oxygen Radicals

(2020) Cindy Gunawan et al.   ACS Applied Materials & Interfaces

Lipoteichoic Acid Biosynthesis Inhibitors as Potent Inhibitors of S. aureus and E. faecalis Growth and Biofilm Formation

(2020) George A. Naclerio et al.   MOLECULES

Liposomes for Antibiotic Encapsulation and Delivery

(2020) Azucena Gonzalez Gomez et al.   ACS Infectious Diseases

Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination

(2020) Youhui Si et al.   Science Advances

Multiple ways to kill bacteria via inhibiting novel cell wall or membrane targets

(2020) George A Naclerio et al.   Future Medicinal Chemistry

Antibiotics Act with vB_AbaP_AGC01 Phage against Acinetobacter baumannii in Human Heat-Inactivated Plasma Blood and Galleria mellonella Models

(2020) Bartłomiej Grygorcewicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis

(2020) Vance G. Fowler et al.   JOURNAL OF CLINICAL INVESTIGATION

Vancomycin C-Terminus Guanidine Modifications and Further Insights into an Added Mechanism of Action Imparted by a Peripheral Structural Modification

(2020) Zhi-Chen Wu et al.   ACS Infectious Diseases

Next-Generation Total Synthesis of Vancomycin

(2020) Maxwell J. Moore et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glycosylation-dependent opsonophagocytic activity of staphylococcal protein A antibodies

(2020) Xinhai Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad Bactericidal Activity of the Myoviridae Bacteriophage Lysins LysAm24, LysECD7, and LysSi3 against Gram-Negative ESKAPE Pathogens

(2019) Nataliia Antonova et al.   Viruses-Basel

Principles and Practice of Antibiotic Stewardship in the ICU

(2019) Chiagozie I. Pickens et al.   CHEST

The quinazolinone allosteric inhibitor of PBP2a synergizes with piperacillin and tazobactam against methicillin-resistant Staphylococcus aureus

(2019) Jeshina Janardhanan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action

(2019) Jason H. Yang et al.   CELL

Antibacterial Small Molecules That Potently Inhibit Staphylococcus aureus Lipoteichoic Acid Biosynthesis

(2019) George A. Naclerio et al.   ChemMedChem

Streptococcus pyogenes evades adaptive immunity through specific IgG glycan hydrolysis

(2019) Andreas Naegeli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Potential of marine natural products against drug-resistant bacterial infections

(2019) Miaomiao Liu et al.   LANCET INFECTIOUS DISEASES

Bacterial Metabolism and Antibiotic Efficacy

(2019) Jonathan M. Stokes et al.   Cell Metabolism

Microbiology and Preclinical Review of Omadacycline

(2019) James A Karlowsky et al.   CLINICAL INFECTIOUS DISEASES

Prospects for the Use of New Technologies to Combat Multidrug-Resistant Bacteria

(2019) Renata Lima et al.   Frontiers in Pharmacology

Antibiotics: past, present and future

(2019) Matthew I Hutchings et al.   CURRENT OPINION IN MICROBIOLOGY

A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier

(2019) Elizabeth M. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase

(2019) Bo Ma et al.   Nature Communications

Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria

(2019) John M. Leech et al.   Cell Host & Microbe

Development of novel nanoantibiotics using an outer membrane vesicle-based drug efflux mechanism

(2019) Weiwei Huang et al.   JOURNAL OF CONTROLLED RELEASE

A Peptidomimetic Antibiotic Interacts with the Periplasmic Domain of LptD from Pseudomonas aeruginosa

(2018) Gloria Andolina et al.   ACS Chemical Biology

A Novel Inhibitor of the LolCDE ABC Transporter Essential for Lipoprotein Trafficking in Gram-Negative Bacteria

(2018) Nicholas N. Nickerson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial Stewardship and Intensive Care Unit (ICU) Mortality: A systematic review

(2018) Patrick J Lindsay et al.   CLINICAL INFECTIOUS DISEASES

N -(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria

(2018) Clement Opoku-Temeng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Are Phage Lytic Proteins the Secret Weapon To Kill Staphylococcus aureus?

(2018) Diana Gutiérrez et al.   mBio

Antibacterial Activity of Silver Nanoparticles: Structural Effects

(2018) Shaoheng Tang et al.   Advanced Healthcare Materials

Alanine Enhances Aminoglycosides-Induced ROS Production as Revealed by Proteomic Analysis

(2018) Jin-zhou Ye et al.   Frontiers in Microbiology

Understanding antibiotic resistance via outer membrane permeability

(2018) Ishan Ghai et al.   Infection and Drug Resistance

Phage Therapy for a Multidrug-Resistant Acinetobacter baumannii Craniectomy Site Infection

(2018) Stephanie LaVergne et al.   Open Forum Infectious Diseases

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

(2018) Patrick Jault et al.   LANCET INFECTIOUS DISEASES

Pathogen elimination by probiotic Bacillus via signalling interference

(2018) Pipat Piewngam et al.   NATURE

Design, synthesis and antimicrobial activities of thiouracil derivatives containing triazolo-thiadiazole as SecA inhibitors

(2017) Penglei Cui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Peripheral modifications of [Ψ[CH 2 NH]Tpg 4 ]vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics

(2017) Akinori Okano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety, tolerability, and immunogenicity of a 4-antigen Staphylococcus aureus vaccine (SA4Ag): Results from a first-in-human randomised, placebo-controlled phase 1/2 study

(2017) Robert W. Frenck et al.   VACCINE

Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models

(2017) In Young Hwang et al.   Nature Communications

Distinct Expression of Immunoglobulin-Binding Proteins in Shiga Toxin-Producing Escherichia coli Implicates High Protein Stability and a Characteristic Phenotype

(2017) et al.   Toxins

Staphylococcus aureus Manipulates Innate Immunity through Own and Host-Expressed Proteases

(2017) Giampiero Pietrocola et al.   Frontiers in Cellular and Infection Microbiology

The Disulfide Bond of the Peptide Thanatin Is Dispensible for Its Antimicrobial ActivityIn VivoandIn Vitro

(2016) Bo Ma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fusion between fluid liposomes and intact bacteria: study of driving parameters and in vitro bactericidal efficacy

(2016) Yufan Ma et al.   International Journal of Nanomedicine

Current applications of nanoparticles in infectious diseases

(2016) Hinojal Zazo et al.   JOURNAL OF CONTROLLED RELEASE

Human commensals producing a novel antibiotic impair pathogen colonization

(2016) Alexander Zipperer et al.   NATURE

Copper Reduction and Contact Killing of Bacteria by Iron Surfaces

(2015) Salima Mathews et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Exogenous Alanine and/or Glucose plus Kanamycin Kills Antibiotic-Resistant Bacteria

(2015) Bo Peng et al.   Cell Metabolism

Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens

(2015) M. Kavruk et al.   CHEMICAL COMMUNICATIONS

D-Enantiomeric Peptides that Eradicate Wild-Type and Multidrug-Resistant Biofilms and Protect against Lethal Pseudomonas aeruginosa Infections

(2015) César de la Fuente-Núñez et al.   CHEMISTRY & BIOLOGY

Design, Synthesis and Evaluation of Triazole-Pyrimidine Analogues as SecA Inhibitors

(2015) Jianmei Cui et al.   ChemMedChem

Small-Molecule Inhibitors of Gram-Negative Lipoprotein Trafficking Discovered by Phenotypic Screening

(2015) Sarah M. McLeod et al.   JOURNAL OF BACTERIOLOGY

Novel Antibacterial Targets and Compounds Revealed by a High-Throughput Cell Wall Reporter Assay

(2015) Asha S. Nayar et al.   JOURNAL OF BACTERIOLOGY

A Peptidomimetic Antibiotic Targets Outer Membrane Proteins and Disrupts Selectively the Outer Membrane inEscherichia coli

(2015) Matthias Urfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Antibiotic (E)-3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one

(2015) Renee Bouley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

(2015) Sophie M. Lehar et al.   NATURE

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Efficacy profile of a bivalent Staphylococcus aureusglycoconjugated vaccine in adults on hemodialysis: Phase III randomized study

(2015) Ali Fattom et al.   Human Vaccines & Immunotherapeutics

Efficient suppression of biofilm formation by a nucleic acid aptamer

(2015) Yi Ning et al.   Pathogens and Disease

Alteration of intracellular protein expressions as a key mechanism of the deterioration of bacterial denitrification caused by copper oxide nanoparticles

(2015) Yinglong Su et al.   Scientific Reports

IgG4 Subclass-Specific Responses to Staphylococcus aureus Antigens Shed New Light on Host-Pathogen Interaction

(2014) Jasper Swierstra et al.   INFECTION AND IMMUNITY

Penicillin-binding protein 2a of methicillin-resistantStaphylococcus aureus

(2014) Jennifer Fishovitz et al.   IUBMB LIFE

Staphylococcus aureusinfection induces protein A–mediated immune evasion in humans

(2014) Noel T. Pauli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity

(2014) Peter I. O’Daniel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response

(2014) César de la Fuente-Núñez et al.   PLoS Pathogens

Wall Teichoic Acids of Gram-Positive Bacteria

(2013) Stephanie Brown et al.   Annual Review of Microbiology

Discovery of Wall Teichoic Acid Inhibitors as Potential Anti-MRSA β-Lactam Combination Agents

(2013) Hao Wang et al.   CHEMISTRY & BIOLOGY

Clinical relevance of the ESKAPE pathogens

(2013) Jack N Pendleton et al.   Expert Review of Anti-Infective Therapy

Effect of an Investigational Vaccine for Preventing Staphylococcus aureus Infections After Cardiothoracic Surgery

(2013) Vance G. Fowler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Application of S-thanatin, an antimicrobial peptide derived from thanatin, in mouse model of Klebsiella pneumoniae infection

(2013) Guoqiu Wu et al.   PEPTIDES

Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria

(2013) Stefan G. Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Protein A in the Evasion of Host Adaptive Immune Responses by Staphylococcus aureus

(2013) F. Falugi et al.   mBio

An Antibiotic That Inhibits a Late Step in Wall Teichoic Acid Biosynthesis Induces the Cell Wall Stress Stimulon in Staphylococcus aureus

(2012) Jennifer Campbell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibody orientation at bacterial surfaces is related to invasive infection

(2012) Pontus Nordenfelt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cleavable Cationic Antibacterial Amphiphiles: Synthesis, Mechanism of Action, and Cytotoxicities

(2012) Jiaul Hoque et al.   LANGMUIR

Recover the lost art of drug discovery

(2012) Kim Lewis   NATURE

Recent developments for Pseudomonas vaccines

(2011) Anurag Sharma et al.   Human vaccines & immunotherapeutics

Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen

(2011) N. Saeidi et al.   Molecular Systems Biology

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors

(2011) C. K. Cusumano et al.   Science Translational Medicine

The first low μM SecA inhibitors

(2010) Weixuan Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus

(2010) Kyungae Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Interaction of antimicrobial peptide s-thanatin with lipopolysaccharide in vitro and in an experimental mouse model of septic shock caused by a multidrug-resistant clinical isolate of Escherichia coli

(2010) Guoqiu Wu et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Underlying Mechanism of In vivo and In vitro Activity of C-terminal–amidated Thanatin Against Clinical Isolates of Extended-Spectrum β-lactamase–Producing Escherichia coli

(2010) Zheng Hou et al.   JOURNAL OF INFECTIOUS DISEASES

Cleavage of IgGs by proteases associated with invasive diseases

(2010) Randall J. Brezski et al.   mAbs

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

(2010) N. Srinivas et al.   SCIENCE

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

Discovery of a Small Molecule that Blocks Wall Teichoic Acid Biosynthesis inStaphylococcus aureus

(2009) Jonathan G. Swoboda et al.   ACS Chemical Biology

The immunoglobulin-binding Eib proteins from Escherichia coli are receptors for IgG Fc

(2009) Jack C. Leo et al.   MOLECULAR IMMUNOLOGY

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

(2009) Lynette Cegelski et al.   Nature Chemical Biology

Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting

(2009) Ranjana Pathania et al.   Nature Chemical Biology

Combining use of a panel of ssDNA aptamers in the detection of Staphylococcus aureus

(2009) Xiaoxiao Cao et al.   NUCLEIC ACIDS RESEARCH

Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

(2008) Louis B. Rice   JOURNAL OF INFECTIOUS DISEASES

In vivo studies of polyacrylate nanoparticle emulsions for topical and systemic applications

(2008) Kerriann Greenhalgh et al.   Nanomedicine-Nanotechnology Biology and Medicine

Rifabutin encapsulated in liposomes exhibits increased therapeutic activity in a model of disseminated tuberculosis

(2007) M.M. Gaspar et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Antimicrobial effectiveness of liposomal polymyxin B against resistant Gram-negative bacterial strains

(2007) Misagh Alipour et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS