In vivo killing of primary HIV-infected cells by peripheral-injected early memory–enriched anti-HIV duoCAR T cells

Reference standards for accurate validation and optimization of assays that determine integrated lentiviral vector copy number in transduced cells

(2021) Barbara S. Paugh et al.   Scientific Reports

Stem cell–derived CAR T cells traffic to HIV reservoirs in macaques

(2021) Isaac M. Barber-Axthelm et al.   JCI Insight

HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses

(2021) Kiera L. Clayton et al.   Cell Host & Microbe

Robust CAR-T memory formation and function via hematopoietic stem cell delivery

(2021) Anjie Zhen et al.   PLoS Pathogens

Feasibility of real-time in vivo 89Zr-DFO-labeled CAR T-cell trafficking using PET imaging

(2020) Suk Hyun Lee et al.   PLoS One

Visualization of T Cell Migration in the Spleen Reveals a Network of Perivascular Pathways that Guide Entry into T Zones

(2020) Anne Chauveau et al.   IMMUNITY

HIV-Resistant and HIV-Specific CAR-Modified CD4+ T Cells Mitigate HIV Disease Progression and Confer CD4+ T Cell Help In Vivo

(2020) Colby R. Maldini et al.   MOLECULAR THERAPY

Robust Expansion of HIV CAR T Cells Following Antigen Boosting in ART-Suppressed Nonhuman Primates

(2020) Blake J. Rust et al.   BLOOD

Next-Generation Manufacturing Protocols Enriching TSCM CAR T Cells Can Overcome Disease-Specific T Cell Defects in Cancer Patients

(2020) Silvia Arcangeli et al.   Frontiers in Immunology

Automated Manufacture of Autologous CD19 CAR-T Cells for Treatment of Non-hodgkin Lymphoma

(2020) Zachary Jackson et al.   Frontiers in Immunology

Real-time killing assays to assess the potency of a new anti-SIV CAR

(2020) Francoise Haeseleer et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study

(2020) Jeremy S Abramson et al.   LANCET

Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir

(2020) Lea Patasic et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo

(2020) Colby R. Maldini et al.   NATURE MEDICINE

Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir

(2020) Jason Neidleman et al.   eLife

Improving safety of cancer immunotherapy via delivery technology

(2020) Doudou Hu et al.   BIOMATERIALS

TCF-1 regulates HIV-specific CD8+ T cell expansion capacity

(2020) Rachel L. Rutishauser et al.   JCI Insight

An altered cytotoxic program of CD8+ T-cells in HIV-infected patients despite HAART-induced viral suppression

(2019) Federico Perdomo-Celis et al.   PLoS One

Infectious virus persists in CD4+ T cells and macrophages in ART-suppressed SIV-infected Macaques

(2019) Celina M. Abreu et al.   JOURNAL OF VIROLOGY

CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques

(2019) Jin Fan et al.   Nature Communications

The HIV Reservoir in Monocytes and Macrophages

(2019) Michelle E. Wong et al.   Frontiers in Immunology

Successful anti‐CD19 CAR T‐cell therapy in HIV‐infected patients with refractory high‐grade B‐cell lymphoma

(2019) Jeremy S. Abramson et al.   CANCER

Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model

(2019) Kim Anthony-Gonda et al.   Science Translational Medicine

Attacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform

(2019) Eytan Herzig et al.   CELL

Induction of a central memory and stem cell memory phenotype in functionally active CD4+ and CD8+ CAR T cells produced in an automated good manufacturing practice system for the treatment of CD19+ acute lymphoblastic leukemia

(2018) Franziska Blaeschke et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy

(2018) Georgios L. Moschovakis et al.   Cellular & Molecular Immunology

Resistance of HIV-infected macrophages to CD8+ T lymphocyte–mediated killing drives activation of the immune system

(2018) Kiera L. Clayton et al.   NATURE IMMUNOLOGY

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

(2018) Joseph A. Fraietta et al.   NATURE MEDICINE

Chimeric antigen receptor T-cell approaches to HIV cure

(2018) Anne-Sophie Kuhlmann et al.   Current Opinion in HIV and AIDS

Reducing Ex Vivo Culture Improves the Anti-leukemic Activity of Chimeric Antigen Receptor (CAR)-T Cells

(2018) Saba Ghassemi et al.   Cancer Immunology Research

Simian Immunodeficiency Virus (SIV)-Specific Chimeric Antigen Receptor-T Cells Engineered to Target B Cell Follicles and Suppress SIV Replication

(2018) Kumudhini Preethi Haran et al.   Frontiers in Immunology

Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1–2 trial

(2018) Frederick L Locke et al.   LANCET ONCOLOGY

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

(2018) Stephen J. Schuster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potent In Vivo NK Cell-Mediated Elimination of HIV-1-Infected Cells Mobilized by a gp120-Bispecific and Hexavalent Broadly Neutralizing Fusion Protein

(2017) Ariola Bardhi et al.   JOURNAL OF VIROLOGY

Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells

(2017) Malika Hale et al.   MOLECULAR THERAPY

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

(2017) Sattva S. Neelapu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS

(2017) Anjie Zhen et al.   PLoS Pathogens

Chimeric Antigen Receptor T Cells Guided by the Single-Chain Fv of a Broadly Neutralizing Antibody Specifically and Effectively Eradicate Virus Reactivated from Latency in CD4 + T Lymphocytes Isolated from HIV-1-Infected Individuals Receiving Suppressive Combined Antiretroviral Therapy

(2016) Bingfeng Liu et al.   JOURNAL OF VIROLOGY

Persistent HIV-1 replication maintains the tissue reservoir during therapy

(2016) Ramon Lorenzo-Redondo et al.   NATURE

Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+T Cell Killing

(2015) Jennifer N. Rainho et al.   JOURNAL OF VIROLOGY

Novel CD4-Based Bispecific Chimeric Antigen Receptor Designed for Enhanced Anti-HIV Potency and Absence of HIV Entry Receptor Activity

(2015) Li Liu et al.   JOURNAL OF VIROLOGY

Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo

(2015) D Sommermeyer et al.   LEUKEMIA

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

(2015) Kai Deng et al.   NATURE

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

(2015) Yoshinori Fukazawa et al.   NATURE MEDICINE

BLT humanized mice as a small animal model of HIV infection

(2015) Marshall E Karpel et al.   Current Opinion in Virology

Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15

(2014) Y. Xu et al.   BLOOD

Superior T memory stem cell persistence supports long-lived T cell memory

(2013) Enrico Lugli et al.   JOURNAL OF CLINICAL INVESTIGATION

Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome

(2012) A. Astrakhan et al.   BLOOD

The Majority of Freshly Sorted Simian Immunodeficiency Virus (SIV)-Specific CD8+T Cells Cannot Suppress Viral Replication in SIV-Infected Macrophages

(2012) Lara Vojnov et al.   JOURNAL OF VIROLOGY

Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells

(2012) Enrico Lugli et al.   Nature Protocols

Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

(2012) J. Scholler et al.   Science Translational Medicine

Replication competent molecular clones of HIV-1 expressing Renilla luciferase facilitate the analysis of antibody inhibition in PBMC

(2010) Tara G. Edmonds et al.   VIROLOGY

Manufacturing Validation of Biologically Functional T Cells Targeted to CD19 Antigen for Autologous Adoptive Cell Therapy

(2009) Daniel Hollyman et al.   JOURNAL OF IMMUNOTHERAPY

Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

(2009) N. Cartier et al.   SCIENCE