An altered cytotoxic program of CD8+ T-cells in HIV-infected patients despite HAART-induced viral suppression

Residual T cell activation and skewed CD8+ T cell memory differentiation despite antiretroviral therapy-induced HIV suppression

(2018) Ramla F. Tanko et al.   CLINICAL IMMUNOLOGY

Mechanisms of CD8+ T cell-mediated suppression of HIV/SIV replication

(2018) Julia Bergild McBrien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection

(2016) B E Kiniry et al.   Mucosal Immunology

Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection

(2016) Korey R. Demers et al.   PLoS Pathogens

Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques

(2016) Emily R. Roberts et al.   PLoS Pathogens

The effect of HAART-induced HIV suppression on circulating markers of inflammation and immune activation

(2015) Nikolas Itaru Wada et al.   AIDS

Programmed death-1 expression on CD4+ and CD8+ T cells in treated and untreated HIV disease

(2014) Leslie R. Cockerham et al.   AIDS

NFATc1 Regulates PD-1 Expression upon T Cell Activation

(2014) K. J. Oestreich et al.   JOURNAL OF IMMUNOLOGY

Impaired Degranulation and Proliferative Capacity of Mycobacterium tuberculosis–Specific CD8+ T Cells in HIV-Infected Individuals With Latent Tuberculosis

(2014) Ameeta S. Kalokhe et al.   JOURNAL OF INFECTIOUS DISEASES

High Eomesodermin Expression among CD57+ CD8+ T Cells Identifies a CD8+ T Cell Subset Associated with Viral Control during Chronic Human Immunodeficiency Virus Infection

(2014) F. Simonetta et al.   JOURNAL OF VIROLOGY

HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality

(2014) Sergio Serrano-Villar et al.   PLoS Pathogens

Predictors of CD4:CD8 Ratio Normalization and Its Effect on Health Outcomes in the Era of Combination Antiretroviral Therapy

(2013) Victor Leung et al.   PLoS One

Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection

(2012) L. Trautmann et al.   BLOOD

Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression

(2011) A. R. Hersperger et al.   BLOOD

Alteration of CD8+ T cell effector diversity during HIV-1 infection with discordant normalization in effective antiretroviral therapy

(2011) Nattawat Onlamoon et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

High Level of Perforin Expression in T Cells: An Early Prognostic Marker of the Severity of Herpesvirus Reactivation after Allogeneic Stem Cell Transplantation in Adults

(2010) F. L. Pietersma et al.   CLINICAL INFECTIOUS DISEASES

Causes of Death in HIV‐1–Infected Patients Treated with Antiretroviral Therapy, 1996–2006: Collaborative Analysis of 13 HIV Cohort Studies

(2010)   CLINICAL INFECTIOUS DISEASES

Proliferation Capacity and Cytotoxic Activity Are Mediated by Functionally and Phenotypically Distinct Virus-Specific CD8 T Cells Defined by Interleukin-7R  (CD127) and Perforin Expression

(2010) C. Cellerai et al.   JOURNAL OF VIROLOGY

Perforin Expression Directly Ex Vivo by HIV-Specific CD8+ T-Cells Is a Correlate of HIV Elite Control

(2010) Adam R. Hersperger et al.   PLoS Pathogens

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

(2009) Fernando Cruz-Guilloty et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dissociated Production of Perforin, Granzyme B, and IFN-γ by HIV-Specific CD8+ Cells in HIV Infection

(2008) Stefanie Kuerten et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells

(2008) D Kassahn et al.   CELL DEATH AND DIFFERENTIATION

CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy

(2008) A Steel et al.   HIV MEDICINE

Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control

(2008) Stephen A. Migueles et al.   IMMUNITY

The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression

(2008) P. K. Chattopadhyay et al.   JOURNAL OF LEUKOCYTE BIOLOGY