Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir

Immunogenicity of Chimeric Antigen Receptor T-Cell Therapeutics

(2019) Boris Gorovits et al.   BIODRUGS

Strategies to eradicate HIV from infected patients: elimination of latent provirus reservoirs

(2019) Ivan Sadowski et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Bispecific chimeric antigen receptors targeting the CD4 binding site and high-mannose Glycans of gp120 optimized for anti–human immunodeficiency virus potency and breadth with minimal immunogenicity

(2018) Mustafa H. Ghanem et al.   CYTOTHERAPY

Markers of the HIV-1 reservoir

(2018) Timothée Bruel et al.   Current Opinion in HIV and AIDS

Therapeutic Targeting of HIV Reservoirs: How to Give T Cells a New Direction

(2018) Hongbing Yang et al.   Frontiers in Immunology

A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy

(2017) Erhao Zhang et al.   Journal of Hematology & Oncology

Long-Duration Complete Remissions of Diffuse Large B Cell Lymphoma after Anti-CD19 Chimeric Antigen Receptor T Cell Therapy

(2017) James N. Kochenderfer et al.   MOLECULAR THERAPY

Genetic Modification of T Cells with Chimeric Antigen Receptors: A Laboratory Manual

(2017) Viktória Golumba-Nagy et al.   Human Gene Therapy Methods

The growing world of CAR T cell trials: a systematic review

(2016) Astrid Holzinger et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Driving gene-engineered T cell immunotherapy of cancer

(2016) Laura A Johnson et al.   CELL RESEARCH

Targeted antibody-mediated depletion of murine CD19 CAR T cells permanently reverses B cell aplasia

(2016) Paulina J. Paszkiewicz et al.   JOURNAL OF CLINICAL INVESTIGATION

Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts

(2016) M Cartellieri et al.   Blood Cancer Journal

Animal Models for HIV Cure Research

(2016) Benjamin B. Policicchio et al.   Frontiers in Immunology

Genetic engineering of chimeric antigen receptors using lamprey derived variable lymphocyte receptors

(2016) Robert Moot et al.   Molecular Therapy-Oncolytics

Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy

(2015) Andreas Plückthun   Annual Review of Pharmacology and Toxicology

Exclusive Transduction of Human CD4+T Cells upon Systemic Delivery of CD4-Targeted Lentiviral Vectors

(2015) Qi Zhou et al.   JOURNAL OF IMMUNOLOGY

Novel CD4-Based Bispecific Chimeric Antigen Receptor Designed for Enhanced Anti-HIV Potency and Absence of HIV Entry Receptor Activity

(2015) Li Liu et al.   JOURNAL OF VIROLOGY

Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors

(2015) Joanne A. Hammill et al.   Journal for ImmunoTherapy of Cancer

CD19-CAR Trials

(2014) Carlos A. Ramos et al.   CANCER JOURNAL

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

(2014) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

T-cell therapies for HIV

(2013) Sharon Lam et al.   Immunotherapy

Treatment of Diabetic Macular Edema With a Designed Ankyrin Repeat Protein That Binds Vascular Endothelial Growth Factor: A Phase I/II Study

(2012) Peter A. Campochiaro et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety

(2010) V Hoyos et al.   LEUKEMIA

Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I–II study

(2009) Fabio Ciceri et al.   LANCET ONCOLOGY

DARPins: A new generation of protein therapeutics

(2008) Michael T. Stumpp et al.   DRUG DISCOVERY TODAY

CD4-Specific Designed Ankyrin Repeat Proteins Are Novel Potent HIV Entry Inhibitors with Unique Characteristics

(2008) Andreas Schweizer et al.   PLoS Pathogens

Folding and Unfolding Mechanism of Highly Stable Full-Consensus Ankyrin Repeat Proteins

(2007) Svava K. Wetzel et al.   JOURNAL OF MOLECULAR BIOLOGY