Review
Cell Biology
Yitian Zhang, Weihui Zeng, Yumin Xia
Summary: Fibrosis is a common pathological condition associated with abnormal repair after tissue injury, and the TWEAK/Fn14 pathway plays a crucial role in this process.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Benjamin J. Dwyer, Edward J. Jarman, Jully Gogoi-Tiwari, Sofia Ferreira-Gonzalez, Luke Boulter, Rachel V. Guest, Timothy J. Kendall, Dominic Kurian, Alastair M. Kilpatrick, Andrew J. Robson, Eoghan O'Duibhir, Tak Yung Man, Lara Campana, Philip J. Starkey Lewis, Stephen J. Wigmore, John K. Olynyk, Grant A. Ramm, Janina E. E. Tirnitz-Parker, Stuart J. Forbes
Summary: This study highlights the overexpression of TWEAK/Fn14 in human CCA and the upregulation of Fn14 during TAA-induced carcinogenesis. TWEAK modulates the secretion of factors from CCA cells, influencing the polarization of macrophages and promoting cancer-associated fibroblast proliferation in the tumor microenvironment.
JOURNAL OF HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ahmed Aido, Olena Zaitseva, Harald Wajant, Matej Buzgo, Aiva Simaite
Summary: By linking anti-Fn14 antibodies to gold nanoparticles, researchers were able to uncover strong agonistic activity in the antibody molecules presented on the nanoparticles, suggesting a potential for immunotherapeutic applications by exploiting this method.
Article
Oncology
N. Dianah B. Abu Bakar, Rodrigo Carlessi, Jully Gogoi-Tiwari, Julia Kohn-Gaone, Vincent Williams, Marco Falasca, John K. Olynyk, Grant A. Ramm, Janina E. E. Tirnitz-Parker
Summary: The TWEAK/Fn14 signalling pathway plays a crucial role in tissue injury and regeneration, and its involvement in pancreatic injury and cancer is not well understood. This study demonstrates that TWEAK/Fn14 signalling is important in the establishment and progression of chronic pancreatitis, increasing the risk of pancreatic cancer. The findings suggest the TWEAK/Fn14 pathway as a potential therapeutic target.
Article
Multidisciplinary Sciences
David Nagy, Katelin A. Ennis, Ru Wei, Susan C. Su, Christopher A. Hinckley, Rong-Fang Gu, Benbo Gao, Ramiro H. Massol, Chris Ehrenfels, Luke Jandreski, Ankur M. Thomas, Ashley Nelson, Stefka Gyoneva, Mihaly Hajos, Linda C. Burkly
Summary: The TWEAK/Fn14 signaling pathway has been found to acutely dampen synaptic transmission and plasticity in the adult mouse hippocampal slices. Blocking this pathway can improve synaptic function in certain models, indicating its potential therapeutic value in modifying synaptic physiology in the mature brain.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Jonay Poveda, Sara Vazquez-Sanchez, Ana B. Sanz, Alberto Ortiz, Luis M. Ruilope, Gema Ruiz-Hurtado
Summary: The TWEAK-Fn14 axis plays a crucial role in cardiovascular and kidney diseases, potentially contributing to the cardiorenal syndrome.
JOURNAL OF PATHOLOGY
(2021)
Article
Immunology
Beatriz Abos, Elena Perez-Fernandez, Esther Morel, Pedro Perdiguero, Carolina Tafalla
Summary: In rainbow trout, TWEAK 1 plays a role in response to pathogens by modulating the transcription of antimicrobial and pro-inflammatory genes in different leukocyte subsets. Additionally, TWEAK has been established as a B cell differentiation factor in this species.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Wiktoria Ratajczak, Sarah D. Atkinson, Catriona Kelly
Summary: TWEAK, a member of the TNF superfamily, controls various cellular events through different signaling pathways. It has a dual role in protecting healthy tissues and becoming detrimental in chronic inflammatory states. Fn14 and CD163 are the receptors for TWEAK, and the effects of TWEAK vary depending on the receptor it binds to.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Medicine, Research & Experimental
Goekhan Guener, Marlene Assfalg, Kai Zhao, Tobias Dreyer, Shibojyoti Lahiri, Yun Lo, Bianca Ionela Slivinschi, Axel Imhof, Georg Jocher, Laura Strohm, Christian Behrends, Dieter Langosch, Holger Bronger, Christopher Nimsky, Joerg W. Bartsch, Stanley R. Riddell, Harald Steiner, Stefan F. Lichtenthaler
Summary: Fn14 is cleaved by the protease gamma-secretase, leading to secretion of sFn14. Inhibition of gamma-secretase increases full-length Fn14 at the cell surface and enhances TWEAK ligand-stimulated Fn14 signaling. The release of sFn14 can be detected in tumor cells, plasma, and blood from cancer patients, suggesting it as a biomarker for monitoring gamma-secretase activity.
EMBO MOLECULAR MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Wenting Liu, Lu Gao, Xiaojuan Hou, Shiyao Feng, Haixin Yan, Hongyu Pan, Shichao Zhang, Xue Yang, Jinghua Jiang, Fei Ye, Qiudong Zhao, Lixin Wei, Zhipeng Han
Summary: The malignant transformation of hepatic progenitor cells (HPCs) in the inflammatory microenvironment is the root cause of hepatocarcinogenesis. This study identifies the subgroup of HPCs through single-cell RNA sequencing and investigates their phenotype in a primary HCC model. It is found that tumors are formed from HPCs in peritumor tissue, and macrophage-derived TWEAK/Fn14 promotes the expression of ID1 in HPCs, leading to aberrant differentiation of HPCs.
Article
Gastroenterology & Hepatology
Celia Short, Allen Zhong, Jiabo Xu, Elaa Mahdi, Alison Glazier, Nicolas Malkoff, Nicolas Noriega, Theresa Yeo, Kinji Asahina, Kasper S. Wang
Summary: This study found that Prom1-expressing hepatic progenitor cells (HPCs) expand in biliary atresia (BA), giving rise to cholangiocytes within biliary ductular reactions. The TWEAK/FN14 signaling pathway mediates HPC proliferation, leading to fibrogenesis in BA.
Article
Oncology
Jonay Poveda, Laura Gonzalez-Lafuente, Sara Vazquez-Sanchez, Elisa Mercado-Garcia, Elena Rodriguez-Sanchez, Ines Garcia-Consuegra, Ana Belen Sanz, Julian Segura, Maria Fernandez-Velasco, Fernando Liano, Luis M. Ruilope, Gema Ruiz-Hurtado
Summary: This study establishes the relevance of the TWEAK-Fn14 pathway in cardiac dysfunction linked to CRS3, both as a predictor of mortality in patients with AKI and as a Ca2+ mishandling inducer in cardiomyocytes, and highlights the cardioprotective benefits of TWEAK targeting in CRS3.
JOURNAL OF PATHOLOGY
(2023)
Review
Biology
Yaoguo Li, Tiaoyi Xiao, Jun Zou
Summary: This review summarizes recent advances in the study of fish TNF biology and focuses on the molecular properties and immunological functions of the TNF and TNFR superfamily. The research found that fish have a diversified TNF family, partly due to whole genome duplication events.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Henri Chedotal, Dilip Narayanan, Katrine Povlsen, Charlotte H. Gotfredsen, Roberta Brambilla, Michael Gajhede, Anders Bach, Mads H. Clausen
Summary: Tumor necrosis factor (TNF) is a pleiotropic cytokine involved in immune system homeostasis and various diseases. Biologics targeting TNF have limitations, and therefore, small molecules and alternative strategies for modulating TNF signaling are being explored.
DRUG DISCOVERY TODAY
(2023)
Article
Dermatology
Jing-Jing Gu, Cheng-Cheng Deng, Qing-Lan Feng, Jun Liu, Ding-Heng Zhu, Qing Cheng, Zhili Rong, Bin Yang
Summary: Keloids are characterized by excessive deposition of extracellular matrix (ECM), but the mechanisms regulating ECM deposition in keloids are not well understood. This study found that the expression of TWEAK and its receptor Fn14 was significantly decreased in keloids, and TWEAK/Fn14 signaling suppressed the expression of ECM-related genes in keloid fibroblasts. The IRF1 gene was essential for this suppression, and its expression was induced by the TWEAK/Fn14 downstream transcription factor p65. These findings suggest that the relief of TWEAK/Fn14/IRF1-mediated ECM deposition repression contributes to keloid pathogenesis, and provide potential targets for keloid treatment in the future.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Clinical Neurology
Laurie Baert, Mahdia Benkhoucha, Natalia Popa, Mashal C. Ahmed, Benoit Manfroi, Jean Boutonnat, Nathalie Sturm, Gilda Raguenez, Marine Tessier, Olivier Casez, Romain Marignier, Mitra Ahmadi, Alexis Broisat, Catherine Ghezzi, Cyril Rivat, Corinne Sonrier, Michael Hahne, Dominique Baeten, Romain R. Vives, Hugues Lortat-Jacob, Patrice N. Marche, Pascal Schneider, Hans P. Lassmann, Jose Boucraut, Patrice H. Lalive, Bertrand Huard
ANNALS OF NEUROLOGY
(2019)
Article
Multidisciplinary Sciences
Adam H. Barczewski, Michael J. Ragusa, Dale F. Mierke, Maria Pellegrini
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
William K. W. Ho, Lucy Freem, Debiao Zhao, Kevin J. Painter, Thomas E. Woolley, Eamonn A. Gaffney, Michael J. McGrew, Athanasia Tzika, Michel C. Milinkovitch, Pascal Schneider, Armin Drusko, Franziska Matthaeus, James D. Glover, Kirsty L. Wells, Jeanette A. Johansson, Megan G. Davey, Helen M. Sang, Michael Clinton, Denis J. Headon
Article
Biochemistry & Molecular Biology
Alexa Sadier, Monika Twarogowska, Klara Steklikova, Luke Hayden, Anne Lambert, Pascal Schneider, Vincent Laudet, Maria Hovorakova, Vincent Calvez, Sophie Pantalacci
Article
Oncology
Kim L. Clar, Clemens Hinterleitner, Pascal Schneider, Helmut R. Salih, Stefanie Maurer
Article
Cell Biology
Jorge del-Pozo, Neil MacIntyre, Ali Azar, Denis Headon, Pascal Schneider, Michael Cheeseman
DISEASE MODELS & MECHANISMS
(2019)
Review
Biochemistry & Molecular Biology
Jose-Ignacio Rodriguez-Barbosa, Pascal Schneider, Luis Graca, Leo Buehler, Jose-Antonio Perez-Simon, Maria-Luisa del Rio
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Martin Binder, Leah C. Biggs, Mark S. Kronenberg, Pascal Schneider, Irma Thesleff, Anamaria Balic
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Charles R. Midgett, Rachel A. Swindell, Maria Pellegrini, F. Jon Kull
SCIENTIFIC REPORTS
(2020)
Review
Dentistry, Oral Surgery & Medicine
J. D. Oliver, E. C. Turner, L. R. Halpern, S. Jia, P. Schneider, R. N. D'Souza
JOURNAL OF DENTAL RESEARCH
(2020)
Review
Immunology
Mahya Eslami, Pascal Schneider
Summary: This paper discusses the different forms of BAFF, including membrane-bound BAFF, soluble BAFF 3-mer, and soluble BAFF 60-mer, as well as their structure, function, and inhibition profiles. Research suggests that the 60-mer form of BAFF may have a transient and local effect in the human body, with the presence of 60-mer attributes in cord blood possibly being linked to the development of fetal or neonatal B cells.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Article
Cell Biology
Jorge del-Pozo, Denis J. Headon, James D. Glover, Ali Azar, Sonia Schuepbach-Mallepell, Mahmood F. Bhutta, Jon Riddell, Scott Maxwell, Elspeth Milne, Pascal Schneider, Michael Cheeseman
Summary: The growth and function of sebaceous glands and eyelid Meibomian glands depend on the ectodysplasin signalling pathway, which has been found in mice, rats, dogs, and humans. Mutation of genes in this pathway leads to hypohidrotic ectodermal dysplasia, characterized by impaired development of teeth, hair, and cutaneous glands. Additionally, the Zymbal's gland, a large auditory sebaceous gland in the rodent ear canal, has been found to be hypoplastic in mice and rats with a deficiency in the ectodysplasin pathway. Treatment with agonist anti-EDAR antibodies has been shown to rescue the Zymbal's glands in mice. These findings suggest that sebum deficiency is the main factor in the development of bacterial infections, such as otitis externa, and the Eda(Ta) mouse may serve as a useful microbial challenge model for this condition in humans.
DISEASE MODELS & MECHANISMS
(2022)
Article
Biochemistry & Molecular Biology
Alexandra E. Panaitiu, Tamar Basiashvili, Dale F. Mierke, Maria Pellegrini
Summary: Cellular FLICE-like inhibitory protein (cFLIP) plays pivotal roles in various cellular processes and disease states. This study elucidates the structure of a domain of cFLIP and identifies its interactions with FADD and calmodulin, which regulate the function of cFLIP in specific contexts.
Article
Multidisciplinary Sciences
Alexandra T. Linder, Michael Schmidt, Julia Hitschfel, Markus Abeln, Pascal Schneider, Rita Gerardy-Schahn, Anja K. Muenster-Kuehnel, Lars Nitschke
Summary: This study investigates the role of sialoglycans on B cells in cell migration, complement system control, and cellular signaling regulation. The results demonstrate that sialoglycans are crucial for the survival of B cells by counteracting multiple death-inducing pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Holm Schneider, Christine Schweikl, Florian Faschingbauer, Smail Hadj-Rabia, Pascal Schneider
Summary: X-linked hypohidrotic ectodermal dysplasia (XLHED) is a rare developmental disorder that affects sweat glands, teeth, and hair. Treatment with recombinant EDA1 protein can help improve sweat gland development and sweating ability, as well as promote tooth growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)