A review on phytochemical and pharmacological facets of tropical ethnomedicinal plants as reformed DPP-IV inhibitors to regulate incretin activity

Impact of drying methods on natural antioxidants, phenols and flavanones of immature dropped Citrus sinensis L. Osbeck fruits

(2022) Dinesh Kumar et al.   Scientific Reports

Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development

(2022) Safaet Alam et al.   Frontiers in Endocrinology

Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure–Activity Relationship, Kinetics and Interaction Mechanism

(2022) Junkun Pan et al.   Frontiers in Nutrition

Effect of Different Proportions of Phenolics on Antioxidant Potential: Pointers for Bioactive Synergy/Antagonism in Foods and Nutraceuticals

(2022) Tripti Joshi et al.   Proceedings of the National Academy of Sciences, India. Section B

A Review on Annona muricata and Its Anticancer Activity

(2022) Suganya Ilango et al.   Cancers

Insulin Secretory Actions of Ethanol Extract of Eucalyptus citriodora Leaf, including Plasma DPP-IV and GLP-1 Levels in High-Fat-Fed Rats, as Well as Characterization of Biologically Effective Phytoconstituents

(2022) Prawej Ansari et al.   Metabolites

Phytochemicals from Amberboa ramosa as potential DPP-IV inhibitors for the management of Type-II diabetes mellitus: Inferences from in-silico investigations

(2022) Rakesh Kumar Paul et al.   JOURNAL OF MOLECULAR STRUCTURE

Effects of 22 traditional anti-diabetic medicinal plants on DPP-IV enzyme activity and glucose homeostasis in high-fat fed obese diabetic rats

(2021) Prawej Ansari et al.   BIOSCIENCE REPORTS

Pueraria tuberosa: A Review on Traditional Uses, Pharmacology, and Phytochemistry

(2021) Ram Bharti et al.   Frontiers in Pharmacology

Natural products in drug discovery: advances and opportunities

(2021) Atanas G. Atanasov et al.   NATURE REVIEWS DRUG DISCOVERY

A review upon medicinal perspective and designing rationale of DPP-4 inhibitors

(2021) Shubham Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms

(2021) Javad Sharifi-Rad et al.   Oxidative Medicine and Cellular Longevity

Evaluation of freeze crystallization on pomegranate juice quality in comparison with conventional thermal processing

(2021) Patricio Orellana-Palma et al.   Food Bioscience

Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential Isolated from Natural Sources: A Novel Approach for the Management of Diabetes

(2021) Anand-Krishna Singh et al.   Pharmaceuticals

Gravitational assisted three-stage block freeze concentration process for producing enriched concentrated orange juice (Citrus sinensis L.): Multi-elemental profiling and polyphenolic bioactives

(2021) Isabel Cristina da Silva Haas et al.   JOURNAL OF FOOD ENGINEERING

Identification of Potential Dipeptidyl Peptidase (DPP)-IV Inhibitors among Moringa oleifera Phytochemicals by Virtual Screening, Molecular Docking Analysis, ADME/T-Based Prediction, and In Vitro Analyses

(2020) Yang Yang et al.   MOLECULES

Solid lipid nanoparticles enhance the resistance of oat-derived peptides that inhibit dipeptidyl peptidase IV in simulated gastrointestinal fluids

(2020) Lijing Su et al.   Journal of Functional Foods

Phytochemicals in Garlic Extract Inhibit Therapeutic Enzyme DPP-4 and Induce Skeletal Muscle Cell Proliferation: A Possible Mechanism of Action to Benefit the Treatment of Diabetes Mellitus

(2020) Poonam Kalhotra et al.   Biomolecules

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

(2020) Saikat Dewanjee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prunus amygdalus extract exert antidiabetic effect via inhibition of DPP-IV: in-silico and in-vivo approaches

(2020) Vikas Kumar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Flavonoids with Glutathione Antioxidant Synergy: Influence of Free Radicals Inflow

(2020) Igor Ilyasov et al.   Antioxidants

Multi-stage block freeze-concentration of green tea (Camellia sinensis) extract

(2020) D.L. Meneses et al.   JOURNAL OF FOOD ENGINEERING

Inhibitory evaluation of Curculigo latifolia on α-glucosidase, DPP (IV) and in vitro studies in antidiabetic with molecular docking relevance to type 2 diabetes mellitus

(2020) Nur Athirah Zabidi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Identification of Dipeptidyl Peptidase-4 and α-Amylase Inhibitors from Melicope glabra (Blume) T. G. Hartley (Rutaceae) Using Liquid Chromatography Tandem Mass Spectrometry, In Vitro and In Silico Methods

(2020) Alexandra Quek et al.   MOLECULES

Flavonoids for preserving pancreatic beta cell survival and function: A mechanistic review

(2019) Ahmad Ghorbani et al.   BIOMEDICINE & PHARMACOTHERAPY

Molecular Docking: Shifting Paradigms in Drug Discovery

(2019) Luca Pinzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glucagon-like peptide 1 (GLP-1)

(2019) T.D. Müller et al.   Molecular Metabolism

Hormones and oxidative stress: an overview

(2019) Gagan B. N. Chainy et al.   FREE RADICAL RESEARCH

The integrative biology of type 2 diabetes

(2019) Michael Roden et al.   NATURE

Citrus bioflavonoids dipeptidyl peptidase-4 inhibition compared with gliptin antidiabetic medications

(2018) Ankit Gupta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Safety and tolerability of dapagliflozin, saxagliptin and metformin in combination: Post-hoc analysis of concomitant add-on versus sequential add-on to metformin and of triple versus dual therapy with metformin

(2018) Stefano Del Prato et al.   DIABETES OBESITY & METABOLISM

The safety of gliptins : updated data in 2018

(2018) André Jacques Scheen   Expert Opinion On Drug Safety

Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases

(2018) Palanivel Ganesan et al.   International Journal of Nanomedicine

Protection of silver nanoparticles using Eysenhardtia polystachya in peroxide-induced pancreatic β-Cell damage and their antidiabetic properties in zebrafish

(2018) Abraham Heriberto Garcia Campoy et al.   International Journal of Nanomedicine

Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation

(2018) Abu Sayem et al.   MOLECULES

Structure–Activity Relationship and Molecular Docking of Natural Product Library Reveal Chrysin as a Novel Dipeptidyl Peptidase-4 (DPP-4) Inhibitor: An Integrated In Silico and In Vitro Study

(2018) Poonam Kalhotra et al.   MOLECULES

Cyanidin-3-O-glucoside inhibits different enzymes involved in central nervous system pathologies and type-2 diabetes

(2018) Guillermo Cásedas et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Oat globulin peptides regulate antidiabetic drug targets and glucose transporters in Caco-2 cells

(2018) Feng Wang et al.   Journal of Functional Foods

Hypoglycemic effect and mechanism of isoquercitrin as an inhibitor of dipeptidyl peptidase-4 in type 2 diabetic mice

(2018) Lei Zhang et al.   RSC Advances

Antidiabetic phytoconstituents and their mode of action on metabolic pathways

(2018) Sudhanshu Kumar Bharti et al.   Therapeutic Advances in Endocrinology and Metabolism

The PI3K/AKT pathway in obesity and type 2 diabetes

(2018) Xingjun Huang et al.   International Journal of Biological Sciences

DPP-IV Inhibitory Potentials of Flavonol Glycosides Isolated from the Seeds of Lens culinaris: In Vitro and Molecular Docking Analyses

(2018) Bo-Ram Kim et al.   MOLECULES

Dipeptidyl peptidase IV Inhibitory activity of Terminalia arjuna attributes to its cardioprotective effects in experimental diabetes: In silico, in vitro and in vivo analyses

(2018) Ipseeta Ray Mohanty et al.   PHYTOMEDICINE

Biogenic synthesis of Marsilea quadrifolia gold nanoparticles: a study of improved glucose utilization efficiency on 3T3-L1 adipocytes

(2017) Anindita Chowdhury et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Anti-diabetic Potential of Silver Nanoparticles Synthesized with Argyreia nervosa Leaf Extract High Synergistic Antibacterial Activity with Standard Antibiotics Against Foodborne Bacteria

(2017) Ganesh Dattatraya Saratale et al.   JOURNAL OF CLUSTER SCIENCE

Antidiabetic effects of Morus alba fruit polysaccharides on high-fat diet- and streptozotocin-induced type 2 diabetes in rats

(2017) Yukun Jiao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protective effect of cirsimaritin against streptozotocin-induced apoptosis in pancreatic beta cells

(2017) Dahae Lee et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

The Antidiabetic Mechanisms of Polyphenols Related to Increased Glucagon-Like Peptide-1 (GLP1) and Insulin Signaling

(2017) J. Domínguez Avila et al.   MOLECULES

Nanoformulation of Leonotis leonurus to improve its bioavailability as a potential antidiabetic drug

(2017) Frank Odei-Addo et al.   3 Biotech

Nanoformulation of Leonotis leonurus to improve its bioavailability as a potential antidiabetic drug

(2017) Frank Odei-Addo et al.   3 Biotech

Hybrid docking-QSAR studies of DPP-IV inhibition activities of a series of aminomethyl-piperidones

(2016) Zohreh Amini et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Peptides Derived from Soy and Lupin Protein as Dipeptidyl-Peptidase IV Inhibitors: In Vitro Biochemical Screening and in Silico Molecular Modeling Study

(2016) Carmen Lammi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Characterization of peptides from common bean protein isolates and their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress

(2016) Luis Mojica et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Strategies for the Discovery and Development of Anti-Diabetic Drugs from the Natural Products of Traditional Medicines

(2016) Ji-Ming Ye et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Plant-Derived Compounds Targeting Pancreatic Beta Cells for the Treatment of Diabetes

(2015) Yoon Sin Oh   Evidence-based Complementary and Alternative Medicine

Purification and identification of dipeptidyl peptidase (DPP) IV inhibitory peptides from the macroalga Palmaria palmata

(2015) Pádraigín A. Harnedy et al.   FOOD CHEMISTRY

Recent progress in natural products as DPP-4 inhibitors

(2015) Yuanyuan Gao et al.   Future Medicinal Chemistry

Dipeptidyl Peptidase IV Inhibitory Peptides Derived from Oat (Avena sativa L.), Buckwheat (Fagopyrum esculentum), and Highland Barley (Hordeum vulgare trifurcatum (L.) Trofim) Proteins

(2015) Feng Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Molecular Docking and Structure-Based Drug Design Strategies

(2015) Leonardo Ferreira et al.   MOLECULES

Antidiabetic properties of dietary flavonoids: a cellular mechanism review

(2015) Ramachandran Vinayagam et al.   Nutrition & Metabolism

Mechanism-based antidiabetic activity of Fructo- and isomalto-oligosaccharides: Validation by in vivo, in silico and in vitro interaction potential

(2015) Sudhanshu Kumar Bharti et al.   PROCESS BIOCHEMISTRY

Pyrrole alkaloids from the fruits of Morus alba

(2014) Seon Beom Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bioactive Compounds from Culinary Herbs Inhibit a Molecular Target for Type 2 Diabetes Management, Dipeptidyl Peptidase IV

(2014) Allyson M. Bower et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Plants Fagonia cretica L. and Hedera nepalensis K. Koch contain natural compounds with potent dipeptidyl peptidase-4 (DPP-4) inhibitory activity

(2014) Samreen Saleem et al.   JOURNAL OF ETHNOPHARMACOLOGY

Comparative prophylactic effects of α-eleostearic acid rich nano and conventional emulsions in induced diabetic rats

(2014) Debjyoti Paul et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes

(2014) Tesfaye Biftu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dietary stimulators of GLUT4 expression and translocation in skeletal muscle: A mini-review

(2014) Nicholas P. Gannon et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effects of Green Tea Extract on Insulin Resistance and Glucagon-Like Peptide 1 in Patients with Type 2 Diabetes and Lipid Abnormalities: A Randomized, Double-Blinded, and Placebo-Controlled Trial

(2014) Chia-Yu Liu et al.   PLoS One

Purification, characterization and anti-diabetic activity of a polysaccharide from mulberry leaf

(2014) Yao Zhang et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Antagonistic effect of alkaloids and saponins on bioactivity in the quinine tree (Rauvolfia caffra sond.): further evidence to support biotechnology in traditional medicinal plants

(2013) Trizah K Milugo et al.   BMC Complementary and Alternative Medicine

Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

(2013) Jonathan E. Campbell et al.   Cell Metabolism

Dietary flavonoids intake and risk of type 2 diabetes: A meta-analysis of prospective cohort studies

(2013) Yu-Jian Liu et al.   CLINICAL NUTRITION

Berry and Citrus Phenolic Compounds Inhibit Dipeptidyl Peptidase IV: Implications in Diabetes Management

(2013) Junfeng Fan et al.   Evidence-based Complementary and Alternative Medicine

Inhibition of dipeptidyl peptidase activity by flavonol glycosides of guava (Psidium guajava L.): A key to the beneficial effects of guava in type II diabetes mellitus

(2013) Thomas Eidenberger et al.   FITOTERAPIA

Anti-diabetic effect of ramulus mori polysaccharides, isolated from Morus alba L., on STZ-diabetic mice through blocking inflammatory response and attenuating oxidative stress

(2013) Chao Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Extracts from Leonurus sibiricus L. increase insulin secretion and proliferation of rat INS-1E insulinoma cells

(2013) S. Schmidt et al.   JOURNAL OF ETHNOPHARMACOLOGY

Natural product isolation – how to get from biological material to pure compounds

(2013) Franz Bucar et al.   NATURAL PRODUCT REPORTS

A molecular connection ofPterocarpus marsupium, Eugenia jambolanaandGymnema sylvestrewith dipeptidyl peptidase-4 in the treatment of diabetes

(2013) Jayasankar Kosaraju et al.   PHARMACEUTICAL BIOLOGY

Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials

(2012) Lee Hooper et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dietary flavonoid intakes and risk of type 2 diabetes in US men and women

(2012) Nicole M Wedick et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Molecular Docking: A Powerful Approach for Structure-Based Drug Discovery

(2012) Xuan-Yu Meng et al.   Current Computer-Aided Drug Design

Chronic Ingestion of Flavan-3-ols and Isoflavones Improves Insulin Sensitivity and Lipoprotein Status and Attenuates Estimated 10-Year CVD Risk in Medicated Postmenopausal Women With Type 2 Diabetes: A 1-year, double-blind, randomized, controlled trial

(2012) P. J. Curtis et al.   DIABETES CARE

A nanostructured liquid crystalline formulation of 20(S)-protopanaxadiol with improved oral absorption

(2012) Xin Jin et al.   FITOTERAPIA

Antidiabetic activity and molecular docking of fructooligosaccharides produced by Aureobasidium pullulans in poloxamer-407-induced T2DM rats

(2012) Sudhanshu Kumar Bharti et al.   FOOD CHEMISTRY

In vitro inhibition of dipeptidyl peptidase IV by peptides derived from the hydrolysis of amaranth (Amaranthus hypochondriacus L.) proteins

(2012) Aída J. Velarde-Salcedo et al.   FOOD CHEMISTRY

Supercritical Carbon Dioxide Extraction of Flavonoids from Pomelo (Citrus grandis (L.) Osbeck) Peel and Their Antioxidant Activity

(2012) Jin-Zhe He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Charting, Navigating, and Populating Natural Product Chemical Space for Drug Discovery

(2012) Hugo Lachance et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antihyperglycemic, hypolipidemic and antioxidant activities of ethanolic extract of Commiphora mukul gum resin in fructose-fed male Wistar rats

(2012) B. Ramesh et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Antihyperglycemic and antioxidant effects of a flavanone, naringenin, in streptozotocin–nicotinamide-induced experimental diabetic rats

(2012) T. Annadurai et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Antihyperglycemic activity with DPP-IV inhibition of alkaloids from seed extract of Castanospermum australe: Investigation by experimental validation and molecular docking

(2012) Sudhanshu Kumar Bharti et al.   PHYTOMEDICINE

Anti-diabetic effect of a traditional Chinese medicine formula

(2012) Hsiu-Ju Wang et al.   Food & Function

Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice

(2011) Punit Bansal et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

A review of gliptins in 2011

(2011) André J Scheen   EXPERT OPINION ON PHARMACOTHERAPY

Flavonoid-Rich Cocoa Consumption Affects Multiple Cardiovascular Risk Factors in a Meta-Analysis of Short-Term Studies

(2011) Mark G. Shrime et al.   JOURNAL OF NUTRITION

Comparison of current docking tools for the simulation of inhibitor binding by the transmembrane domain of the sarco/endoplasmic reticulum calcium ATPase

(2010) Michael Lape et al.   BIOPHYSICAL CHEMISTRY

Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review

(2010) C. F. Deacon   DIABETES OBESITY & METABOLISM

Ameliorative role of conjugated linolenic acid isomers against oxidative DNA damage induced by sodium arsenite in rat model

(2010) S.S. Saha et al.   FOOD AND CHEMICAL TOXICOLOGY

Solubility limits of cholesterol, lanosterol, ergosterol, stigmasterol, and β-sitosterol in electroformed lipid vesicles

(2010) Mark M. Stevens et al.   Soft Matter

Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine

(2009) Ihab M. Al-masri et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY