Review
Plant Sciences
Mutiu Idowu Kazeem, Habeeb Adebodun Bankole, Azeez Ayomide Fatai, Gbemisola Morounke Saibu, Adedoja Dorcas Wusu
Summary: Aloe is a commonly used medicinal plant for treating various conditions, including inflammation, infection, cancer, and diabetes mellitus. However, there is a lack of comprehensive reports on all Aloe species with antidiabetic properties. This review revealed that Aloe vera is the most common Aloe species with antidiabetic potentials.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Review
Medicine, Research & Experimental
Md Mominur Rahman, Puja Sutro Dhar, Sumaia, Fazilatunnesa Anika, Limon Ahmed, Md Rezaul Islam, Nazneen Ahmeda Sultana, Simona Cavalu, Ovidiu Pop, Abdur Rauf
Summary: Diabetes mellitus is a common metabolic syndrome, and people are turning to plant-based medications due to the side effects of chemically generated drugs. This article focuses on anti-diabetic plants, their bioactive constituents, chemical characterization, and the role of plant-based diets in diabetes management.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biology
Ayudiah Rizki Utami, Iman Permana Maksum, Yusi Deawati
Summary: High blood sugar, known as hyperglycemia, can lead to serious complications such as cardiovascular problems, impaired eyesight, and kidney dysfunction. Diabetes mellitus is a metabolic disease that causes hyperglycemia and has high mortality rates. This review discusses the use of the natural compound berberine as an antidiabetic agent and its mechanism of action, as well as its potential anti-inflammatory and antioxidant properties.
Review
Pharmacology & Pharmacy
Bao Sun, Shiqiong Huang, Jiecan Zhou
Summary: Diabetes mellitus increases the risk of viral infections, especially in cases of poor glycemic control. Patients with diabetes who are acutely unwell with suspected or confirmed COVID-19 face complex management and therapy. Antidiabetic agents play a crucial role in DM patients with coronavirus infection, guiding clinical therapeutic choices.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sha Zhu, Qifeng Bai, Lanqing Li, Tingyang Xu
Summary: Drug repositioning plays a significant role in drug development and machine learning methods can accelerate this process. This article focuses on the repurposing potential of type 2 diabetes mellitus drugs for various diseases.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Food Science & Technology
Abdelhakim Bouyahya, Nasreddine El Omari, Naoual Elmenyiy, Fatima-Ezzahrae Guaouguaou, Abdelaali Balahbib, Omar Belmehdi, Najoua Salhi, Hamada Imtara, Hanae Naceiri Mrabti, Mohamed El-Shazly, Youssef Bakri
Summary: This review discusses the antidiabetic properties of Moroccan medicinal plants, highlighting their mechanism of action and potential application as potent antidiabetic agents. Clinical trials of these natural treasures demonstrated impressive results in controlling diabetes and its manifestations, making them promising candidates for future drug development.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tianduanyi Wang, Otto I. Pulkkinen, Tero Aittokallio
Summary: Most drug molecules have the ability to modulate multiple target proteins, which can lead to both therapeutic effects and unwanted side effects. Evaluating the selectivity of a compound is an important factor in drug development and repurposing efforts. Traditional methods for characterizing selectivity fall short in quantifying how selective a compound is against a particular target protein. In this study, we propose an optimization-based selectivity scoring method that allows for the identification of potent and selective compounds against given kinase targets. We demonstrate the effectiveness of this method in finding highly selective compounds in computational experiments using a large-scale kinase inhibitor dataset.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Wendy A. Warr, Marc C. Nicklaus, Christos A. Nicolaou, Matthias Rarey
Summary: Designing new medicines more cheaply and quickly is closely related to exploring chemical space more widely and efficiently. This review focuses on the collection of millions or even billions of enumerated chemical structures, as well as larger chemical spaces that are not fully enumerated. New technologies for searching large libraries and combinatorially in chemical space are discussed, along with space navigation techniques and the impact of autonomous laboratories on synthesis of designed compounds. Challenges and opportunities for the future are summarized.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Review
Pharmacology & Pharmacy
Saikat Mitra, Rajib Das, Talha Bin Emran, Rafiuddin Khan Labib, Noor-E-Tabassum, Fahadul Islam, Rohit Sharma, Islamudin Ahmad, Firzan Nainu, Kumarappan A. Chidambaram, Fahad A. Alhumaydhi, Deepak Chandran, Raffaele Capasso, Polrat Wilairatana
Summary: Garlic, a widely used plant medicinal product, contains a compound called diallyl disulfide (DADS) that has shown anticancer effects against various types of tumors, including gynecological, hematological, lung, and gastrointestinal cancers. The mechanisms of action of DADS against cancer cells involve regulating epithelial-mesenchymal transition and inhibiting invasion and migration.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Geriatrics & Gerontology
Juan Huang, Nanqu Huang, Di Cui, Jingshan Shi, Yu Qiu
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease, and type 2 diabetes mellitus (T2DM) increases the risk of AD. The use of clinical antidiabetic medication in AD has gained attention, but most show potential only in basic research and not in clinical research. This review discusses the opportunities and challenges of antidiabetic medication used in AD, particularly for patients with AD caused by elevated blood glucose or/and insulin resistance.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Ellie Esfandiari Nazzaro, Fahad Y. Sabei, Walter K. Vogel, Mohamad Nazari, Katelyn S. Nicholson, Philip R. Gafken, Olena Taratula, Oleh Taratula, Monika A. Davare, Mark Leid
Summary: Ewing's sarcoma is a rare and aggressive cancer of bone and soft tissue characterized by specific chromosomal translocations. Current cytotoxic chemotherapies effectively treat localized disease but can lead to treatment-related morbidities, and the survival rate for patients with relapsed or metastatic disease remains low. A new compound, ML111, was identified through high-throughput screening and showed promising inhibitory effects on Ewing's sarcoma cells in vitro and in vivo, suggesting its potential as a new drug lead for further preclinical studies.
Article
Biochemistry & Molecular Biology
Charles Arineitwe, Ogunyemi Oderinlo, Matshawandile Tukulula, Setshaba Khanye, Andile Khathi, Ntethelelo Sibiya
Summary: Diabetes mellitus (DM) and its complications have a significant impact on healthcare systems worldwide. In this study, four novel thiazolidinedione (TZD)-derivatives were synthesized and evaluated for their anti-diabetic properties. The derivatives showed strong binding to peroxisome proliferator-activated receptor-gamma (PPAR-gamma), similar to rosiglitazone. TZDD2 increased glucose uptake in liver cells compared to control. The derivatives exhibited inhibition activity in various enzymatic assays, including alpha-amylase, alpha-glucosidase, aldose reductase, and dipeptidyl peptidase-4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Ricardo Moreira Borges, Fernanda das Neves Costa, Fernanda O. Chagas, Andrew Magno Teixeira, Jaewon Yoon, Marcio Barczyszyn Weiss, Camila Manoel Crnkovic, Alan Cesar Pilon, Bruno C. Garrido, Luz Adriana Betancur, Abel M. Forero, Leonardo Castellanos, Freddy A. Ramos, Monica T. Pupo, Stefan Kuhn
Summary: DAFdiscovery is a pipeline designed to accelerate the annotation and discovery of bioactive compounds by combining mass spectrometry, nuclear magnetic resonance, and bioactivity data and using statistical total correlation spectroscopy and statistical heterospectroscopy calculations. It provides a simple-to-use method for analyzing data from different sources in various situations.
PHYTOCHEMICAL ANALYSIS
(2023)
Review
Pharmacology & Pharmacy
Kondeti R. Shanmugam, Bhasha Shanmugam, Ganjikunta Subbaiah, Sahukari Ravi, Kesireddy S. Reddy
Summary: Diabetes is a major public health problem worldwide, and alternative medicine is needed for treatment. Many herbal plants and their bioactive compounds show anti-diabetic effects, indicating therapeutic potential.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Food Science & Technology
Muhammad Shahid, Shazrul Fazry, Ahmad Azfaralariff, Ahmed Abdul Kareem Najm, Douglas Law, Mukram M. Mackeen
Summary: This study aimed to identify the bioactive compounds and evaluate the antidiabetic and cytotoxic potential of G. atroviridis fruit extract. The extract showed promising inhibitory potential against α-amylase and α-glucosidase enzymes and low cytotoxicity on L6 cells. Furthermore, 18 potent antidiabetic bioactive compounds were identified.
Article
Biochemistry & Molecular Biology
Prerana B. B. Jadhav, Shailaja B. B. Jadhav, Mehrukh Zehravi, Mohammad S. S. Mubarak, Fahadul Islam, Philippe Jeandet, Sharuk L. L. Khan, Nazmul Hossain, Salma Rashid, Long Chiau Ming, Md. Moklesur Rahman Sarker, Mohd Fahami Nur Azlina
Summary: The aim of this study was to synthesize carbohydrazide derivatives as DPP-IV inhibitors and evaluate their antidiabetic activity. Molecular docking, ADMET analysis, and drug-likeness guidelines were used for simulations. The synthesized compounds showed excellent hypoglycemic potential both in vitro and in vivo, and could be used as leads in developing novel antidiabetic agents.
Article
Biochemistry & Molecular Biology
Pallavi Kishor Vawhal, Shailaja B. Jadhav, Sumit Kaushik, Kahnu Charan Panigrahi, Chandan Nayak, Humaira Urmee, Sharuk L. Khan, Falak A. Siddiqui, Fahadul Islam, Aziz Eftekhari, Abdullah R. Alzahrani, Mohd Fahami Nur Azlina, Md. Moklesur Rahman Sarker, Ibrahim Abdel Aziz Ibrahim
Summary: Recent research has shown that DPP-IV inhibitors can effectively treat type 2 diabetes. This study aimed to develop coumarin-based sulphonamides as potential DPP-IV inhibitors. Among the synthesized compounds, 6i and 6j exhibited the most potent DPP-IV inhibition.
Article
Food Science & Technology
Jianping Nie, Wei Liao, Zijie Zhang, Minjiao Zhang, Yuxi Wen, Esra Capanoglu, Md Moklesur Rahman Sarker, Ruiyu Zhu, Chao Zhao
Summary: This review introduces a 3D co-culture intestinal organoid system developed from stem cells, which can simulate human tissues and be used for studying glucose metabolism diseases and drug screening. The gut has been identified as an important site for studying the interactions among glucose metabolism, gut microbial metabolism, and gut microbiota. The construction methods and progress of 3D intestinal organoid systems compared to traditional 2D culture methods are also summarized in the manuscript.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Mehmet Firat Baran, Cumali Keskin, Ayse Baran, Abdulkerim Hatipoglu, Mahmut Yildiztekin, Selcuk Kucukaydin, Kadri Kurt, Hulya Hosgoren, Md. Moklesur Rahman Sarker, Albert Sufianov, Ozal Beylerli, Rovshan Khalilov, Aziz Eftekhari
Summary: This study focuses on the synthesis and characterization of silver nanoparticles (AgNPs) using Allium cepa peel and evaluates their antimicrobial, antioxidant, and anticholinesterase activities. The biosynthesized nanoparticles were characterized using various techniques, and their crystal size and zeta potential were determined. AC-AgNPs showed strong growth inhibitory activities against specific microorganisms, exhibited antioxidant properties, and demonstrated inhibitory effects on key enzymes. Overall, this eco-friendly and cost-effective method has potential applications in biomedicine and industry.
Article
Pharmacology & Pharmacy
Shopnil Akash, Arafat Hossain, Nobendu Mukerjee, Md. Moklesur Rahman Sarker, Mohammad Firoz Khan, Md. Jamal Hossain, Mohammad A. Rashid, Ajoy Kumer, Arabinda Ghosh, Darwin A. Leon-Figueroa, Joshuan J. Barboza, Bijaya Kumar Padhi, Ranjit Sah
Summary: During the second phase of SARS-CoV-2, a black fungus infection called Mucormycosis emerged among hospitalized COVID-19 patients, increasing the death rate. In addition, other pathogenic diseases like Monkeypox and Marburg virus have also impacted global health. Due to their severe pathogenic capabilities and rapid spread, policymakers are concerned about these pathogens. However, there are currently no standard therapies available to manage and treat these conditions.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Microbiology
Suaidah Ramli, Yuan Seng Wu, Kalaivani Batumalaie, Rhanye Mac Guad, Ker Woon Choy, Ashok Kumar, Subash C. B. Gopinath, Md. Moklesur Rahman Sarker, Vetriselvan Subramaniyan, Mahendran Sekar, Neeraj Kumar Fuloria, Shivkanya Fuloria, Suresh V. Chinni, Gobinath Ramachawolran
Summary: This review focuses on the therapeutic efficacy and molecular mechanisms of Withania somnifera (WS) extracts and their phytochemicals against SARS-CoV-2 infection. It also discusses the use of molecular docking in developing potential inhibitors from WS to target the virus and host cell receptors. Additionally, the review explores the use of nanoformulations or nanocarriers in enhancing WS delivery for improved bioavailability and treatment efficacy.
Article
Food Science & Technology
Jinlin Fan, Zheng Xiao, Wanwei Qiu, Chao Zhao, Chao Yi, Dongmei Lin, Zhanxi Lin
Summary: This study used GC-QTOF-MS metabolomics and multivariate statistical analysis to investigate the dynamic changes of metabolites during the fermentation of JUNCAO wine. It identified key metabolic pathways and differential metabolites, providing a comprehensive overview of metabolite changes during fermentation.
Article
Behavioral Sciences
Yajun Huang, Na Li, Chengfeng Yang, Yan Lin, Yuxi Wen, Lingjun Zheng, Chao Zhao
Summary: Research on the relationship between gut microbiota and animal neurophysiology and behavior has grown rapidly recently. Swarming insects, like honeybees, are suitable models for investigating the molecular mechanisms that control insect behavior. The honeybee gut bacteria model is established quickly and has a higher flux, making it useful for understanding intestinal diseases and finding molecular therapeutic targets. This review focused on the contributions of the honeybee model in learning cognition and microbiome research, particularly on the correlation between gut microbiota and brain development.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Food Science & Technology
Aijun Tong, Dengwei Wang, Xiaoyan Liu, Zhiqun Li, Runfan Zhao, Bin Liu, Chao Zhao
Summary: This study evaluated the hypoglycemic effects of low molecular weight polysaccharides fractions from Laminaria japonica (LJOO) on mice with T2DM. The results showed that LJOO decreased FBG and insulin concentrations, altered the gut microbiota composition, increased the population of beneficial bacteria, and decreased the population of harmful bacteria. Additionally, LJOO stimulated the growth of SCFA-producing bacteria, resulting in increased SCFAs levels.
Article
Food Science & Technology
Jianzhou Li, Xiaohua Chen, Ziyan Xie, Lin Liang, Anping Li, Chao Zhao, Yuxi Wen, Zaixiang Lou
Summary: This study screened lactic acid bacteria (LAB) with strong antagonistic ability against Pseudomonas aeruginosa (P. aeruginosa) and evaluated the regulatory mechanism of LAB against P. aeruginosa. The results showed that the selected LAB strains inhibited the growth, biofilm formation, and pyocyanin expression of P. aeruginosa, and promoted the expression of autoinducer-2. Lactipantibacillus plantarum (Lp. plantarum) LPyang affected the metabolic processes of P. aeruginosa by influencing metabolic substances, such as LysoPC, oxidized glutathione, betaine, etc. These findings provide new insights into the antagonistic activity of Lp. plantarum LPyang against P. aeruginosa.
Review
Food Science & Technology
Zhengxin Chen, Weihao Wu, Yuxi Wen, Lizhu Zhang, Yanglin Wu, Muhammad Salman Farid, Hesham R. El-Seedi, Esra Capanoglu, Chao Zhao
Summary: Pigment is a significant food additive that greatly impacts the sensory aspect of food. Natural sources of healthy and non-toxic edible pigments are gaining attention. Algae serves as an important natural pigment source, containing chlorophyll, phycoerythrin, carotene, and other natural pigments. Apart from coloring, pigments also have powerful physiological activities like antioxidants, anti-inflammatory, anti-obesity, and lipid-lowering properties. This review focuses on three pigments found in seaweed, presenting their main structural properties and functions, bridging the gap in pigment reviews with seaweed as the main focus. The research in this review provides a basis for the development of new health foods and offers new directions for the use of seaweed chlorophyll in the food and pharmaceutical industries.
FOOD PRODUCTION PROCESSING AND NUTRITION
(2023)
Article
Agriculture, Multidisciplinary
Minjiao Zhang, Suyue Lu, Yihan Chen, Xue Wu, Zexu Zhao, Chao Zhao
Summary: Lacto-N-fucopentaoses (LNFPs) are important components of human milk oligosaccharides (HMOs) and have various functional activities. Chemical and enzymatic synthesis are two commonly used methods to produce LNFPs, with enzymatic synthesis offering advantages such as mild reaction conditions and high yield. However, few studies have explored the use of in vivo fermentation for LNFPs production, despite its cost advantage. This paper aims to review the synthesis methods, functional activities, and emerging trends in the development of LNFPs.
JOURNAL OF AGRICULTURE AND FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiaoqing Li, Lu Xu, Xinan Peng, Huiting Zhang, Meng Kang, Yiqi Jiang, Haibo Shi, Haiyan Chen, Chao Zhao, Yigang Yu, Ruiting Ma, Xueli Li, Yong Cao
Summary: The anti-inflammatory effect of ellagic acid (EA) was studied in a mouse model of chronic colonic inflammation. EA administration alleviated colonic inflammation phenotypes, reshaped gut microbiota composition, and activated tight junction and PPAR signaling pathways.
Article
Biochemistry & Molecular Biology
Ruiyu Zhu, Shuo Shan, Su Zhou, Zhen Chen, Yuanfeng Wu, Wei Liao, Chao Zhao, Qiang Chu
Summary: In this study, Saccharomyces cerevisiae KD was used to efficiently degrade patulin and alleviate the biotoxicity caused by patulin. The results showed that Saccharomyces cerevisiae KD could effectively degrade patulin, reduce oxidative stress and intestinal damage. Furthermore, Saccharomyces cerevisiae KD could regulate gene expression levels to control the ROS level and GSH content, thus decreasing intestinal damage.
Article
Environmental Sciences
Arifa Sultana, Sabiha Rahman Mim, Ananya Saha, Fahmida Yesmin, Md. Rafat Tahsin, Nasiba Binte Bahar, Kazi Rubiya Fatema, Saimon Shahriar, Kazi Milenur Rahman Prattay, Fazle Rabbi, Fabiha Noushin, Mithun Samodder, Qurratul Ain Sadia, Jannatul Ferdous, Md. Ariful Haque Mamun, Mohammad Ikram Uddin, Tahmina Akter, Md. Mustafizur Rahman, Md. Moklesur Rahman Sarker, Md. Ruhul Kuddus, Fahima Aktar, Jakir Ahmed Chowdhury, Abu Asad Chowdhury, Shaila Kabir, Sultan Mehtap Bueyueker, Md. Sohanur Rahman, Md. Habibur Rahman, Md. Shah Amran
Summary: Mass vaccination programs have been effective in reducing the severity of the pandemic, but there have been reports of adverse effects in Turkey and Bangladesh. This study aimed to evaluate the adverse effects of different vaccines in both countries and the population's willingness to continue vaccination despite the side effects. An online survey was conducted from July to December 2021, and the questionnaire was shared with vaccinated individuals in Turkey and Bangladesh. The study found that a significant percentage of respondents experienced side effects, with pain at the injection site being the most common. However, there were no significant adverse events reported after receiving the COVID-19 vaccines in both countries. The vaccines showed similar patterns of efficacy and safety during the study period.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
