The phospholipid code: a key component of dying cell recognition, tumor progression and host–microbe interactions

The Tomato Defensin TPP3 Binds Phosphatidylinositol (4,5)-Bisphosphate via a Conserved Dimeric Cationic Grip Conformation To Mediate Cell Lysis

(2015) Amy A. Baxter et al.   MOLECULAR AND CELLULAR BIOLOGY

A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure

(2015) Georgia K. Atkin-Smith et al.   Nature Communications

A phase I clinical trial of bavituximab and paclitaxel in patients with HER2 negative metastatic breast cancer

(2015) Pavani Chalasani et al.   Cancer Medicine

Targeting the PI3K/Akt/mTOR Pathway – Beyond Rapalogs

(2015)   Oncotarget

Increased Exposure of Phosphatidylethanolamine on the Surface of Tumor Vascular Endothelium

(2015) Jason H. Stafford et al.   NEOPLASIA

Vascular Endothelial-Targeted Therapy Combined with Cytotoxic Chemotherapy Induces Inflammatory Intratumoral Infiltrates and Inhibits Tumor Relapses after Surgery

(2015) Brendan F. Judy et al.   NEOPLASIA

MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands

(2014) S. Toda et al.   BLOOD

Role of Phosphatidylserine Receptors in Enveloped Virus Infection

(2014) K. Morizono et al.   JOURNAL OF VIROLOGY

Bavituximab plus paclitaxel and carboplatin for the treatment of advanced non-small-cell lung cancer

(2014) Raghunadharao Digumarti et al.   LUNG CANCER

Antifungal Plant Defensins: Mechanisms of Action and Production

(2014) Kim Vriens et al.   MOLECULES

Unexpected link between an antibiotic, pannexin channels and apoptosis

(2014) Ivan K. H. Poon et al.   NATURE

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

(2014) K. Segawa et al.   SCIENCE

Phosphatidylserine receptors: Enhancers of enveloped virus entry and infection

(2014) Sven Moller-Tank et al.   VIROLOGY

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Multivalent Adhesion Molecule 7 Clusters Act as Signaling Platform for Host Cellular GTPase Activation and Facilitate Epithelial Barrier Dysfunction

(2014) Jenson Lim et al.   PLoS Pathogens

Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

(2014) Ivan KH Poon et al.   eLife

Functional role of cardiolipin in mitochondrial bioenergetics

(2013) Giuseppe Paradies et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Activation of blood coagulation in cancer: implications for tumour progression

(2013) Luize G. Lima et al.   BIOSCIENCE REPORTS

New method for purifying histidine-rich glycoprotein from human plasma redefines its functional properties

(2013) Kruti K. Patel et al.   IUBMB LIFE

Role of the Phosphatidylserine Receptor TIM-1 in Enveloped-Virus Entry

(2013) S. Moller-Tank et al.   JOURNAL OF VIROLOGY

Development of PI3K inhibitors: lessons learned from early clinical trials

(2013) Jordi Rodon et al.   Nature Reviews Clinical Oncology

A MAM7 Peptide-Based Inhibitor of Staphylococcus aureus Adhesion Does Not Interfere with In Vitro Host Cell Function

(2013) Catherine Alice Hawley et al.   PLoS One

Structural and Functional Studies of a Phosphatidic Acid-Binding Antifungal Plant Defensin MtDef4: Identification of an RGFRRR Motif Governing Fungal Cell Entry

(2013) Uma Shankar Sagaram et al.   PLoS One

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

Membrane-Active Peptides and the Clustering of Anionic Lipids

(2012) P. Wadhwani et al.   BIOPHYSICAL JOURNAL

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The TIM and TAM Families of Phosphatidylserine Receptors Mediate Dengue Virus Entry

(2012) Laurent Meertens et al.   Cell Host & Microbe

Yersinia Entry into Host Cells Requires Rab5-Dependent Dephosphorylation of PI(4,5)P2 and Membrane Scission

(2012) Helen Sarantis et al.   Cell Host & Microbe

Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs

(2012) Jae-Yeol Kim et al.   EMBO JOURNAL

Targeting the PI3K signaling pathway in cancer therapy

(2012) Chandra Bartholomeusz et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Dimerization of Plant Defensin NaD1 Enhances Its Antifungal Activity

(2012) Fung T. Lay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coagulation and cancer: biological and clinical aspects

(2012) A. FALANGA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structural Basis for Interactions of the Phytophthora sojae RxLR Effector Avh5 with Phosphatidylinositol 3-Phosphate and for Host Cell Entry

(2012) Furong Sun et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plant defensins: Common fold, multiple functions

(2012) Nicole L. van der Weerden et al.   Fungal Biology Reviews

Membrane-active host defense peptides – Challenges and perspectives for the development of novel anticancer drugs

(2011) Sabrina Riedl et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Matrix vesicles: structure, composition, formation and function in calcification

(2011) Roy et al.   Frontiers in Bioscience-Landmark

Hepatitis C Virus Stimulates the Phosphatidylinositol 4-Kinase III Alpha-Dependent Phosphatidylinositol 4-Phosphate Production That Is Essential for Its Replication

(2011) K. L. Berger et al.   JOURNAL OF VIROLOGY

Flippin' lipids

(2011) Marcus R Clark   NATURE IMMUNOLOGY

Outer membrane adhesion factor multivalent adhesion molecule 7 initiates host cell binding during infection by Gram-negative pathogens

(2011) A. M. Krachler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus

(2011) A. S. Kondratowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Distribution and Function of Phosphatidylserine in Cellular Membranes

(2010) Peter A. Leventis et al.   Annual Review of Biophysics

Histidine-rich glycoprotein is a novel plasma pattern recognition molecule that recruits IgG to facilitate necrotic cell clearance via Fc RI on phagocytes

(2010) I. K. H. Poon et al.   BLOOD

External Lipid PI3P Mediates Entry of Eukaryotic Pathogen Effectors into Plant and Animal Host Cells

(2010) Shiv D. Kale et al.   CELL

Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication

(2010) Nai-Yun Hsu et al.   CELL

Helicobacter pylori Exploits Host Membrane Phosphatidylserine for Delivery, Localization, and Pathophysiological Action of the CagA Oncoprotein

(2010) Naoko Murata-Kamiya et al.   Cell Host & Microbe

Bacterial membrane lipids in the action of antimicrobial agents

(2010) Richard M. Epand et al.   JOURNAL OF PEPTIDE SCIENCE

Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells

(2010) S Bafna et al.   ONCOGENE

A Vibrio Effector Protein Is an Inositol Phosphatase and Disrupts Host Cell Membrane Integrity

(2010) C. A. Broberg et al.   SCIENCE

Phosphoinositides Direct Equine Infectious Anemia Virus Gag Trafficking and Release

(2010) Fiona Fernandes et al.   TRAFFIC

RIP Kinases at the Crossroads of Cell Death and Survival

(2009) Wim Declercq et al.   CELL

Molecular mechanisms of late apoptotic/necrotic cell clearance

(2009) I K H Poon et al.   CELL DEATH AND DIFFERENTIATION

The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease

(2009) Bengt Fadeel et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Targeting the PI3K signaling pathway in cancer

(2009) Kwok-Kin Wong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Simultaneous tissue factor expression and phosphatidylserine exposure account for the highly procoagulant pattern of melanoma cell lines

(2009) Clarice Kirszberg et al.   MELANOMA RESEARCH

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness

(2009) Sarah A Scott et al.   Nature Chemical Biology

Review article: Coagulation cascade and therapeutics update: Relevance to nephrology. Part 1: Overview of coagulation, thrombophilias and history of anticoagulants

(2009) REBECCA L C ADAMS et al.   NEPHROLOGY

Solution NMR Characterizations of Oligomerization and Dynamics of Equine Infectious Anemia Virus Matrix Protein and Its Interaction with PIP2†

(2008) Kang Chen et al.   BIOCHEMISTRY

Enteropathogenic Escherichia coli Subverts Phosphatidylinositol 4,5-Bisphosphate and Phosphatidylinositol 3,4,5-Trisphosphate upon Epithelial Cell Infection

(2008) Hagit Sason et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting inside-out phosphatidylserine as a therapeutic strategy for viral diseases

(2008) M Melina Soares et al.   NATURE MEDICINE

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selective cancer cell cytotoxicity of enantiomeric 9-mer peptides derived from beetle defensins depends on negatively charged phosphatidylserine on the cell surface

(2008) Takashi Iwasaki et al.   PEPTIDES

Vaccinia Virus Uses Macropinocytosis and Apoptotic Mimicry to Enter Host Cells

(2008) J. Mercer et al.   SCIENCE

Salmonella-Containing Vacuoles: Directing Traffic and Nesting to Grow

(2008) Malina A. Bakowski et al.   TRAFFIC