Sustainable and Affordable Synthesis of (Deuterated) N-Methyl/Ethyl Amines from Nitroarenes

From hydrogen autotransfer process to deuterium autotransfer process: The N-trideuteromethylation of amines with deuterated methanol to trideuteromethylated amines catalyzed by a Cp*Ir complex bearing a flexible bridging and functional ligand

(2022) Peng Liu et al.   JOURNAL OF CATALYSIS

Simple RuCl3‐catalyzed N‐Methylation of Amines and Transfer Hydrogenation of Nitroarenes using Methanol

(2021) Kishore Natte et al.   ChemCatChem

N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal–Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H2O)]

(2021) Peng Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Recent developments in reductive N-methylation with base-metal catalysts

(2021) Vishakha Goyal et al.   TETRAHEDRON

Manganese-Catalyzed One-Pot Conversion of Nitroarenes into N -Methylarylamines Using Methanol

(2020) Benjamin G. Reed-Berendt et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Selective mono-N-methylation of nitroarenes with methanol catalyzed by atomically dispersed NHC-Ir solid assemblies

(2020) Jiaquan Wang et al.   JOURNAL OF CATALYSIS

Selective N‐Monomethylation of Amines and Nitroarenes using Methanol over an Encapsulated Iridium Nanocatalyst

(2019) Aixiao Fu et al.   Asian Journal of Organic Chemistry

Lutidine-Based Chiral Pincer Manganese Catalysts for Enantioselective Hydrogenation of Ketones

(2019) Linli Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Methylation of Nitroarenes with Methanol

(2019) Lin Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Manganese Catalyzed Hydrogenation of Carbamates and Urea Derivatives

(2019) Uttam Kumar Das et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The 25th Anniversary of the Buchwald–Hartwig Amination: Development, Applications, and Outlook

(2019) Paola A. Forero-Cortés et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Catalytic Deuterium Incorporation within Metabolically Stable β-Amino C–H Bonds of Drug Molecules

(2019) Yejin Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Commercial Pd/C-Catalyzed N-Methylation of Nitroarenes and Amines Using Methanol as Both C1 and H2 Source

(2019) Vishakha Goyal et al.   JOURNAL OF ORGANIC CHEMISTRY

Practical synthesis of C1 deuterated aldehydes enabled by NHC catalysis

(2019) Huihui Geng et al.   Nature Catalysis

N-Monomethylation of Aromatic Amines with Methanol via PNHP-Pincer Ru Catalysts

(2018) Osamu Ogata et al.   ORGANIC LETTERS

Well-Defined Phosphine-Free Iron-Catalyzed N-Ethylation and N-Methylation of Amines with Ethanol and Methanol

(2018) Alexis Lator et al.   ORGANIC LETTERS

FDA approves first deuterated drug

(2017) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

N-Methylation of Amines with Methanol Catalyzed by a Cp*Ir Complex Bearing a Functional 2,2′-Bibenzimidazole Ligand

(2017) Ran Liang et al.   ORGANIC LETTERS

Utilization of CO2 as a C1 Building Block for Catalytic Methylation Reactions

(2017) Yuehui Li et al.   ACS Catalysis

Highly Active and Selective Manganese C=O Bond Hydrogenation Catalysts: The Importance of the Multidentate Ligand, the Ancillary Ligands, and the Oxidation State

(2016) Fabian Kallmeier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Stable Manganese Pincer Catalyst for the Selective Dehydrogenation of Methanol

(2016) María Andérez-Fernández et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective Catalytic Hydrogenations of Nitriles, Ketones, and Aldehydes by Well-Defined Manganese Pincer Complexes

(2016) Saravanakumar Elangovan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective α-Deuteration of Amines and Amino Acids Using D2O

(2016) Basujit Chatterjee et al.   ORGANIC LETTERS

Efficient and selective N-alkylation of amines with alcohols catalysed by manganese pincer complexes

(2016) Saravanakumar Elangovan et al.   Nature Communications

N-Methylation of Amines with Methanol at Room Temperature

(2015) Vasily N. Tsarev et al.   ORGANIC LETTERS

Direct N-Alkylation of Aromatic Amines Using a Microflow Reactor: Enhancement of Selectivity and Reactivity

(2015) Jin-Hyun Jeong et al.   SYNLETT

Efficient Ruthenium-Catalyzed N-Methylation of Amines Using Methanol

(2015) Tuan Thanh Dang et al.   ACS Catalysis

Copper catalysed Ullmann type chemistry: from mechanistic aspects to modern development

(2014) Carlo Sambiagio et al.   CHEMICAL SOCIETY REVIEWS

The Methylation Effect in Medicinal Chemistry

(2011) Eliezer J. Barreiro et al.   CHEMICAL REVIEWS

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

(2011) Tina R White et al.   Nature Chemical Biology