From hydrogen autotransfer process to deuterium autotransfer process: The N-trideuteromethylation of amines with deuterated methanol to trideuteromethylated amines catalyzed by a Cp*Ir complex bearing a flexible bridging and functional ligand

Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules

(2022) Sara Kopf et al.   CHEMICAL REVIEWS

Scalable and selective deuteration of (hetero)arenes

(2022) Wu Li et al.   Nature Chemistry

Borrowing Hydrogen for Organic Synthesis

(2021) Benjamin G. Reed-Berendt et al.   ACS Central Science

Ru-Catalyzed Selective Catalytic Methylation and Methylenation Reaction Employing Methanol as the C1 Source

(2021) Nandita Biswas et al.   JOURNAL OF ORGANIC CHEMISTRY

From selective transfer hydrogenation to selective hydrogen auto-transfer process: An efficient method for the synthesis of alkenyl ketones via iridium-catalyzed α-alkylation of ketones with alkenyl alcohols

(2021) Xiangchao Xu et al.   JOURNAL OF CATALYSIS

Transfer Hydrogenation of Ketones and Imines with Methanol under Base-Free Conditions Catalyzed by an Anionic Metal–Ligand Bifunctional Iridium Catalyst

(2020) Rongzhou Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Dicarboxylic Acids from Aqueous Solutions of Diols Accompanied by the Evolution of Hydrogen Catalyzed by an Iridium Complex Bearing a Bipyridonate Ligand

(2020) Genki Toyooka et al.   ChemSusChem

N-Methylation of Amines with Methanol in Aqueous Solution Catalyzed by a Water-Soluble Metal–Ligand Bifunctional Dinuclear Iridium Catalyst

(2020) Chong Meng et al.   JOURNAL OF ORGANIC CHEMISTRY

Selective mono-N-methylation of nitroarenes with methanol catalyzed by atomically dispersed NHC-Ir solid assemblies

(2020) Jiaquan Wang et al.   JOURNAL OF CATALYSIS

Semiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols

(2020) Zhaofei Zhang et al.   Nature Communications

Hydrogen Production from Methanol‐Water Mixture over Immobilized Iridium Complex Catalysts in Vapor‐Phase Flow Reaction

(2020) Sho Yamaguchi et al.   ChemSusChem

Applications of deuterium in medicinal chemistry

(2019) Tracey Pirali et al.   JOURNAL OF MEDICINAL CHEMISTRY

Palladacycle-Phosphine Catalyzed Methylation of Amines and Ketones Using Methanol

(2019) Ramesh Mamidala et al.   JOURNAL OF ORGANIC CHEMISTRY

Commercial Pd/C-Catalyzed N-Methylation of Nitroarenes and Amines Using Methanol as Both C1 and H2 Source

(2019) Vishakha Goyal et al.   JOURNAL OF ORGANIC CHEMISTRY

Practical synthesis of C1 deuterated aldehydes enabled by NHC catalysis

(2019) Huihui Geng et al.   Nature Catalysis

Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C−H Functionalisation for Hydrogen Isotope Exchange

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in One-Pot Synthesis through Borrowing Hydrogen Catalysis

(2018) Avelino Corma et al.   CHEMICAL REVIEWS

Transfer Hydrogenation of Aldehydes and Ketones with Isopropanol under Neutral Conditions Catalyzed by a Metal–Ligand Bifunctional Catalyst [Cp*Ir(2,2′-bpyO)(H2O)]

(2018) Rongzhou Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

N-Monomethylation of Aromatic Amines with Methanol via PNHP-Pincer Ru Catalysts

(2018) Osamu Ogata et al.   ORGANIC LETTERS

Iron-Catalyzed Methylation Using the Borrowing Hydrogen Approach

(2018) Kurt Polidano et al.   ACS Catalysis

Selective mono N-methylation of anilines with methanol catalyzed by rhenium complexes: An experimental and theoretical study

(2018) Duo Wei et al.   JOURNAL OF CATALYSIS

Well-Defined Phosphine-Free Iron-Catalyzed N-Ethylation and N-Methylation of Amines with Ethanol and Methanol

(2018) Alexis Lator et al.   ORGANIC LETTERS

Methylation of Amines and Ketones with Methanol Catalyzed by an Iridium Complex Bearing a 2-Hydroxypyridylmethylene Fragment

(2018) Danfeng Deng et al.   ORGANOMETALLICS

Efficient and Versatile Catalytic Systems for the N-Methylation of Primary Amines with Methanol Catalyzed by N-Heterocyclic Carbene Complexes of Iridium

(2018) Ken-ichi Fujita et al.   SYNTHESIS-STUTTGART

3d-Metal Catalyzed N- and C-Alkylation Reactions via Borrowing Hydrogen or Hydrogen Autotransfer

(2018) Torsten Irrgang et al.   CHEMICAL REVIEWS

Selective N-Formylation and N-Methylation of Amines Using Methanol as a Sustainable C1 Source

(2018) Geunho Choi et al.   ACS Sustainable Chemistry & Engineering

N-Methylation of Amines with Methanol Catalyzed by a Cp*Ir Complex Bearing a Functional 2,2′-Bibenzimidazole Ligand

(2017) Ran Liang et al.   ORGANIC LETTERS

Dehydrogenative Oxidation of Alcohols in Aqueous Media Catalyzed by a Water-Soluble Dicationic Iridium Complex Bearing a Functional N-Heterocyclic Carbene Ligand without Using Base

(2017) Ken-ichi Fujita et al.   ACS Catalysis

Sustainable and Selective Monomethylation of Anilines by Methanol with Solid Molecular NHC-Ir Catalysts

(2017) Jiangbo Chen et al.   ACS Sustainable Chemistry & Engineering

Designing NHC–Copper(I) Dipyridylamine Complexes for Blue Light-Emitting Electrochemical Cells

(2016) Margaux Elie et al.   ACS Applied Materials & Interfaces

Nickel-Catalyzed Methylation of Aryl Halides with Deuterated Methyl Iodide

(2016) Lu Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed, Site-Selective Direct Allylation of Aryl C–H Bonds by Silver-Mediated C–H Activation: A Synthetic and Mechanistic Investigation

(2016) Sarah Yunmi Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-catalysed tritiation of pharmaceuticals

(2016) Renyuan Pony Yu et al.   NATURE

Deuterated drugs draw heavier backing

(2016) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Acceptorless Dehydrogenative Coupling of o-Aminobenzamides with the Activation of Methanol as a C1 Source for the Construction of Quinazolinones

(2016) Feng Li et al.   ORGANIC LETTERS

Acceptorless Dehydrogenative Cyclization of o-Aminobenzyl Alcohols with Ketones to Quinolines in Water Catalyzed by Water-Soluble Metal–Ligand Bifunctional Catalyst [Cp*(6,6′-(OH)2bpy)(H2O)][OTf]2

(2016) Rongzhou Wang et al.   ORGANIC LETTERS

Efficient and selective N-alkylation of amines with alcohols catalysed by manganese pincer complexes

(2016) Saravanakumar Elangovan et al.   Nature Communications

Hydrogen Production from a Methanol-Water Solution Catalyzed by an Anionic Iridium Complex Bearing a Functional Bipyridonate Ligand under Weakly Basic Conditions

(2015) Ken-ichi Fujita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Radionuclides in drug development

(2015) Philipp Uhl et al.   DRUG DISCOVERY TODAY

Methanol Dehydrogenation by Iridium N-Heterocyclic Carbene Complexes

(2015) Jesús Campos et al.   INORGANIC CHEMISTRY

Synthesis of a-Alkylated Ketones via Tandem Acceptorless Dehydrogenation/a-Alkylation from Secondary and Primary Alcohols Catalyzed by Metal–Ligand Bifunctional Iridium Complex [Cp*Ir(2,2′-bpyO)(H2O)]

(2015) Rongzhou Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Efficient Ruthenium-Catalyzed N-Methylation of Amines Using Methanol

(2015) Tuan Thanh Dang et al.   ACS Catalysis

TheN-Alkylation of Sulfonamides with Alcohols in Water Catalyzed by the Water-Soluble Iridium Complex {Cp*Ir[6,6′-(OH)2bpy](H2O)}[OTf]2

(2014) Panpan Qu et al.   ADVANCED SYNTHESIS & CATALYSIS

α-Alkylation of Ketones with Primary Alcohols Catalyzed by a Cp*Ir Complex Bearing a Functional Bipyridonate Ligand

(2014) Feng Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

The Iridium-Catalyzed Synthesis of Symmetrically and Unsymmetrically Alkylated Diamines under Mild Reaction Conditions

(2012) Stefan Michlik et al.   ADVANCED SYNTHESIS & CATALYSIS

On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition-Metal Complexes

(2012) Eric M. Simmons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cooperative Catalysis by Iridium Complexes with a Bipyridonate Ligand: Versatile Dehydrogenative Oxidation of Alcohols and Reversible Dehydrogenation-Hydrogenation between 2-Propanol and Acetone

(2012) Ryoko Kawahara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Use of Radiolabeled Compounds in Drug Metabolism and Pharmacokinetic Studies

(2012) Emre M. Isin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Dehydrogenative Oxidation of Alcohols in Aqueous Media Using Water-Soluble and Reusable Cp*Ir Catalysts Bearing a Functional Bipyridine Ligand

(2012) Ryoko Kawahara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

General and efficient method for direct N-monomethylation of aromatic primary amines with methanol

(2012) Feng Li et al.   RSC Advances

The Catalytic Amination of Alcohols

(2011) Sebastian Bähn et al.   ChemCatChem

Dehydrogenative Oxidation of Primary and Secondary Alcohols Catalyzed by a Cp*Ir Complex Having a Functional C,N-Chelate Ligand

(2011) Ken-ichi Fujita et al.   ORGANIC LETTERS

Discovery, Applications, and Catalytic Mechanisms of Shvo’s Catalyst

(2010) Brian L. Conley et al.   CHEMICAL REVIEWS

Hydrogen Autotransfer in theN-Alkylation of Amines and Related Compounds using Alcohols and Amines as Electrophiles

(2009) Gabriela Guillena et al.   CHEMICAL REVIEWS

Dehydrogenation as a Substrate-Activating Strategy in Homogeneous Transition-Metal Catalysis

(2009) Graham E. Dobereiner et al.   CHEMICAL REVIEWS

Synthesis of 19-trideuteratedent-testosterone and the GABAAreceptor potentiatorsent-androsterone andent-etiocholanolone

(2008) Shirisha Komarapuri et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS