Molecular heterogeneity in the substantia nigra: A roadmap for understanding PD motor pathophysiology

An action potential initiation mechanism in distal axons for the control of dopamine release

(2022) Changliang Liu et al.   SCIENCE

An atlas of transcriptionally defined cell populations in the rat ventral tegmental area

(2022) Robert A. Phillips et al.   Cell Reports

Subthalamic nucleus exclusively evokes dopamine release in the tail of the striatum

(2022) Kathryn L. Todd et al.   JOURNAL OF NEUROCHEMISTRY

Striatal Blood–Brain Barrier Opening in Parkinson's Disease Dementia: A Pilot Exploratory Study

(2022) José A. Pineda‐Pardo et al.   MOVEMENT DISORDERS

Synaptic-like axo-axonal transmission from striatal cholinergic interneurons onto dopaminergic fibers

(2022) Paul F. Kramer et al.   NEURON

Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction

(2022) Zhenhua Liu et al.   Nature Communications

Angiotensin type-1 receptor and ACE2 autoantibodies in Parkinson´s disease

(2022) Carmen M. Labandeira et al.   npj Parkinsons Disease

Motor Onset Topography and Progression in Parkinson's Disease: the Upper Limb Is First

(2021) Mariana H.G. Monje et al.   MOVEMENT DISORDERS

Blood-brain barrier opening with focused ultrasound in Parkinson’s disease dementia

(2021) Carmen Gasca-Salas et al.   Nature Communications

VGLUT2 is a determinant of dopamine neuron resilience in a rotenone model of dopamine neurodegeneration

(2021) Silas A. Buck et al.   JOURNAL OF NEUROSCIENCE

Striatal dopamine mediates hallucination-like perception in mice

(2021) K. Schmack et al.   SCIENCE

Neonatal 6‐OHDA lesion of the SNc induces striatal compensatory sprouting from surviving SNc dopaminergic neurons without VTA contribution

(2021) William Tanguay et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Disruption of mitochondrial complex I induces progressive parkinsonism

(2021) Patricia González-Rodríguez et al.   NATURE

Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins

(2021) Milagros Pereira Luppi et al.   Cell Reports

Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson’s disease

(2021) Tony Oosterveen et al.   Stem Cell Reports

Onset pattern of nigrostriatal denervation in early Parkinson’s disease

(2021) José A Pineda-Pardo et al.   BRAIN

Classification of Midbrain Dopamine Neurons Using Single-Cell Gene Expression Profiling Approaches

(2020) Jean-Francois Poulin et al.   TRENDS IN NEUROSCIENCES

Initiation of pharmacological therapy in Parkinson's disease: when, why, and how

(2020) Rob M A de Bie et al.   LANCET NEUROLOGY

A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

(2020) Benjamin W Okaty et al.   eLife

Pluripotent Stem Cell Therapies for Parkinson Disease: Present Challenges and Future Opportunities

(2020) Tae Wan Kim et al.   Frontiers in Cell and Developmental Biology

Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons

(2020) Rebekah C. Evans et al.   Cell Reports

The Potential of L-Type Calcium Channels as a Drug Target for Neuroprotective Therapy in Parkinson's Disease

(2019) Birgit Liss et al.   Annual Review of Pharmacology and Toxicology

Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development

(2019) Katarína Tiklová et al.   Nature Communications

Specialized coding of sensory, motor and cognitive variables in VTA dopamine neurons

(2019) Ben Engelhard et al.   NATURE

Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity

(2019) Joshua D. Welch et al.   CELL

Neuromelanin, aging, and neuronal vulnerability in Parkinson's disease

(2019) Miquel Vila   MOVEMENT DISORDERS

Striatal circuits for reward learning and decision-making

(2019) Julia Cox et al.   NATURE REVIEWS NEUROSCIENCE

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning

(2019) Junbing Wu et al.   Cell Reports

Calbindin-D28K Limits Dopamine Release in Ventral but Not Dorsal Striatum by Regulating Ca2+ Availability and Dopamine Transporter Function

(2019) Katherine R. Brimblecombe et al.   ACS Chemical Neuroscience

Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons

(2019) Markus Riessland et al.   Cell Stem Cell

Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease

(2019) Julia Benkert et al.   Nature Communications

Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei

(2019) Jing Ren et al.   eLife

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

(2019) Mike A Nalls et al.   LANCET NEUROLOGY

A Spatiomolecular Map of the Striatum

(2019) Antje Märtin et al.   Cell Reports

Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease

(2018) Paul W. Hook et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons

(2018) Thomas Steinkellner et al.   JOURNAL OF CLINICAL INVESTIGATION

Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties

(2018) Benjamin T. Saunders et al.   NATURE NEUROSCIENCE

On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson's Disease

(2018) Nicolas Giguère et al.   Frontiers in Neurology

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Recruitment of calbindin into nigral dopamine neurons protects against MPTP-Induced parkinsonism

(2018) Ken-ichi Inoue et al.   MOVEMENT DISORDERS

Dopamine neuron activity before action initiation gates and invigorates future movements

(2018) Joaquim Alves da Silva et al.   NATURE

Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches

(2018) Jean-Francois Poulin et al.   NATURE NEUROSCIENCE

Dopamine neurons projecting to the posterior striatum reinforce avoidance of threatening stimuli

(2018) William Menegas et al.   NATURE NEUROSCIENCE

A Cortical Pathogenic Theory of Parkinson’s Disease

(2018) Guglielmo Foffani et al.   NEURON

Genetic deletion of vesicular glutamate transporter in dopamine neurons increases vulnerability to MPTP-induced neurotoxicity in mice

(2018) Hui Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons

(2018) Nao Chuhma et al.   eLife

Dopamine Inhibition Differentially Controls Excitability of Substantia Nigra Dopamine Neuron Subpopulations through T-Type Calcium Channels

(2017) Rebekah C. Evans et al.   JOURNAL OF NEUROSCIENCE

Parkinson's Disease Is Not Simply a Prion Disorder

(2017) D. James Surmeier et al.   JOURNAL OF NEUROSCIENCE

Prying into the Prion Hypothesis for Parkinson's Disease

(2017) Patrik Brundin et al.   JOURNAL OF NEUROSCIENCE

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

(2017) Diana Chang et al.   NATURE GENETICS

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

Opposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in mice

(2017) William Menegas et al.   eLife

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

(2016) Gioele La Manno et al.   CELL

The substantia nigra and ventral tegmental dopaminergic neurons from development to degeneration

(2016) YuHong Fu et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Alpha-synuclein aggregates are excluded from calbindin-D28k-positive neurons in dementia with Lewy bodies and a unilateral rotenone mouse model

(2016) Alexandre N. Rcom-H'cheo-Gauthier et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Rapid signalling in distinct dopaminergic axons during locomotion and reward

(2016) M. W. Howe et al.   NATURE

The mouse cortico-striatal projectome

(2016) Houri Hintiryan et al.   NATURE NEUROSCIENCE

Disentangling neural cell diversity using single-cell transcriptomics

(2016) Jean-Francois Poulin et al.   NATURE NEUROSCIENCE

Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism

(2016) Paul D. Dodson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling

(2016) Susanne Nichterwitz et al.   Nature Communications

Glutamate neurons are intermixed with midbrain dopamine neurons in nonhuman primates and humans

(2016) David H. Root et al.   Scientific Reports

Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq

(2016) Ozgun Gokce et al.   Cell Reports

A comprehensive excitatory input map of the striatum reveals novel functional organization

(2016) Barbara J Hunnicutt et al.   eLife

Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits

(2015) Talia N. Lerner et al.   CELL

Identification of neurodegenerative factors using translatome–regulatory network analysis

(2015) Lars Brichta et al.   NATURE NEUROSCIENCE

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass

(2015) William Menegas et al.   eLife

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation

(2014) Guoxiang Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Protective and toxic roles of dopamine in Parkinson's disease

(2014) Juan Segura-Aguilar et al.   JOURNAL OF NEUROCHEMISTRY

Calbindin content and differential vulnerability of midbrain efferent dopaminergic neurons in macaques

(2014) Iria G. Dopeso-Reyes et al.   Frontiers in Neuroanatomy

Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update

(2014) Lars Brichta et al.   Frontiers in Neuroanatomy

Sox6 and Otx2 Control the Specification of Substantia Nigra and Ventral Tegmental Area Dopamine Neurons

(2014) Lia Panman et al.   Cell Reports

Defining Midbrain Dopaminergic Neuron Diversity by Single-Cell Gene Expression Profiling

(2014) Jean-Francois Poulin et al.   Cell Reports

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Parkin Disease

(2013) Karen M. Doherty et al.   JAMA Neurology

The prion hypothesis in Parkinson's disease: Braak to the future

(2013) Naomi P Visanji et al.   Acta Neuropathologica Communications

Calcium, Bioenergetics, and Neuronal Vulnerability in Parkinson's Disease

(2012) D. James Surmeier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Neuroprotective Effect of Overexpression of Calbindin-D28k in an Animal Model of Parkinson’s Disease

(2012) Hong-Hua Yuan et al.   MOLECULAR NEUROBIOLOGY

Neuronal vulnerability, pathogenesis, and Parkinson's disease

(2012) David Sulzer et al.   MOVEMENT DISORDERS

Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons

(2012) Sarah Threlfell et al.   NEURON

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease

(2012) Soosung Kang et al.   Nature Communications

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons

(2010) Chee Yeun Chung et al.   BRAIN

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

Missing pieces in the Parkinson's disease puzzle

(2010) Jose A Obeso et al.   NATURE MEDICINE

Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP

(2010) Michela Di Salvio et al.   NATURE NEUROSCIENCE

Vesicular Glutamate Transport Promotes Dopamine Storage and Glutamate Corelease In Vivo

(2010) Thomas S. Hnasko et al.   NEURON

Robust Pacemaking in Substantia Nigra Dopaminergic Neurons

(2009) J. N. Guzman et al.   JOURNAL OF NEUROSCIENCE

Two types of dopamine neuron distinctly convey positive and negative motivational signals

(2009) Masayuki Matsumoto et al.   NATURE

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

The black stuff and Konstantin Nikolaevich Tretiakoff

(2008) Andrew J. Lees et al.   MOVEMENT DISORDERS