Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson’s disease

Classification of Midbrain Dopamine Neurons Using Single-Cell Gene Expression Profiling Approaches

(2020) Jean-Francois Poulin et al.   TRENDS IN NEUROSCIENCES

Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development

(2019) Katarína Tiklová et al.   Nature Communications

BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic NeuronsIn Vivoand in Human Induced Pluripotent and Neural Stem Cells

(2018) Vukasin M. Jovanovic et al.   JOURNAL OF NEUROSCIENCE

Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation

(2017) Sara Nolbrant et al.   Nature Protocols

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

Neural Subtype Specification from Human Pluripotent Stem Cells

(2016) Yunlong Tao et al.   Cell Stem Cell

Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons

(2015) Consiglia Pacelli et al.   CURRENT BIOLOGY

Molecular heterogeneity of midbrain dopaminergic neurons - Moving toward single cell resolution

(2015) Angela Anderegg et al.   FEBS LETTERS

MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell Death

(2015) Amrita Datta Chaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors

(2015) Navid Nouri et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1+/− mice

(2015) Jingzhong Zhang et al.   NEUROBIOLOGY OF DISEASE

From Intrinsic Firing Properties to Selective Neuronal Vulnerability in Neurodegenerative Diseases

(2015) Francesco Roselli et al.   NEURON

Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease

(2014) Shane Grealish et al.   Cell Stem Cell

Sox6 and Otx2 Control the Specification of Substantia Nigra and Ventral Tegmental Area Dopamine Neurons

(2014) Lia Panman et al.   Cell Reports

Defining Midbrain Dopaminergic Neuron Diversity by Single-Cell Gene Expression Profiling

(2014) Jean-Francois Poulin et al.   Cell Reports

Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development

(2013) J. Yang et al.   DEVELOPMENT

Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity

(2013) Esteban O Mazzoni et al.   NATURE NEUROSCIENCE

A Modular Gain-of-Function Approach to Generate Cortical Interneuron Subtypes from ES Cells

(2013) Edmund Au et al.   NEURON

Transcription Factor-Induced Lineage Programming of Noradrenaline and Motor Neurons from Embryonic Stem Cells

(2013) Jamie Mong et al.   STEM CELLS

Detailed Expression Analysis of Regulatory Genes in the Early Developing Human Neural Tube

(2013) Ulrika Marklund et al.   STEM CELLS AND DEVELOPMENT

GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area

(2012) Stefanie Reyes et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions

(2012) Agnete Kirkeby et al.   Cell Reports

A cytoarchitectonic and chemoarchitectonic analysis of the dopamine cell groups in the substantia nigra, ventral tegmental area, and retrorubral field in the mouse

(2011) YuHong Fu et al.   Brain Structure & Function

Transcription Factor-Induced Lineage Selection of Stem-Cell-Derived Neural Progenitor Cells

(2011) Lia Panman et al.   Cell Stem Cell

A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection

(2011) Francesca L'Episcopo et al.   Molecular Neurodegeneration

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei

(2011) Sandra Blaess et al.   Neural Development

Dkk1 Regulates Ventral Midbrain Dopaminergic Differentiation and Morphogenesis

(2011) Diogo Ribeiro et al.   PLoS One

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

(2011) Michael J. Devine et al.   Nature Communications

Analysis of Dickkopf3 interactions with Wnt signaling receptors

(2010) Rei E. I. Nakamura et al.   GROWTH FACTORS

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

(2010) Vishal M Gohil et al.   NATURE BIOTECHNOLOGY

Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP

(2010) Michela Di Salvio et al.   NATURE NEUROSCIENCE

Wnt1-lmx1a Forms a Novel Autoregulatory Loop and Controls Midbrain Dopaminergic Differentiation Synergistically with the SHH-FoxA2 Pathway

(2009) Sangmi Chung et al.   Cell Stem Cell

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells

(2009) S. Friling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE