Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease

The Potential of L-Type Calcium Channels as a Drug Target for Neuroprotective Therapy in Parkinson's Disease

(2019) Birgit Liss et al.   Annual Review of Pharmacology and Toxicology

Calcium, Dopamine and Neuronal Calcium Sensor 1: Their Contribution to Parkinson’s Disease

(2019) Cristina Catoni et al.   Frontiers in Molecular Neuroscience

Calcium Sensors in Neuronal Function and Dysfunction

(2019) Robert D. Burgoyne et al.   Cold Spring Harbor Perspectives in Biology

Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus

(2019) Jakob J. Gutzmann et al.   Frontiers in Cellular Neuroscience

Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

(2019) Farah H. Siddiqi et al.   Nature Communications

Mechanisms and regulation of dopamine release

(2019) Changliang Liu et al.   CURRENT OPINION IN NEUROBIOLOGY

NCS-1 Deficiency Affects mRNA Levels of Genes Involved in Regulation of ATP Synthesis and Mitochondrial Stress in Highly Vulnerable Substantia nigra Dopaminergic Neurons

(2019) Carsten Simons et al.   Frontiers in Molecular Neuroscience

The Evolving Understanding of Dopamine Neurons in the Substantia Nigra and Ventral Tegmental Area

(2018) Stephanie C. Gantz et al.   Annual Review of Physiology

NCS-1 is a regulator of calcium signaling in health and disease

(2018) Göran R. Boeckel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Genetic risk factors in Parkinson’s disease

(2018) K. J. Billingsley et al.   CELL AND TISSUE RESEARCH

The role of glucocerebrosidase in Parkinson disease pathogenesis

(2018) Matthew E. Gegg et al.   FEBS Journal

Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress

(2018) Jaime N. Guzman et al.   JOURNAL OF CLINICAL INVESTIGATION

On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson's Disease

(2018) Nicolas Giguère et al.   Frontiers in Neurology

Converging pathways in neurodegeneration, from genetics to mechanisms

(2018) Li Gan et al.   NATURE NEUROSCIENCE

Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes

(2018) Charmaine Lang et al.   Cell Stem Cell

Gi/o protein-coupled receptors in dopamine neurons inhibit the sodium leak channel NALCN

(2018) Fabian Philippart et al.   eLife

T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease

(2018) Yoshikuni Tabata et al.   Stem Cell Reports

Calcium, mitochondrial dysfunction and slowing the progression of Parkinson's disease

(2017) D. James Surmeier et al.   EXPERIMENTAL NEUROLOGY

Lower Affinity of Isradipine for L-Type Ca 2+ Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson's Disease

(2017) Nadine J. Ortner et al.   JOURNAL OF NEUROSCIENCE

Dopamine Inhibition Differentially Controls Excitability of Substantia Nigra Dopamine Neuron Subpopulations through T-Type Calcium Channels

(2017) Rebekah C. Evans et al.   JOURNAL OF NEUROSCIENCE

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

(2017) J.A. Obeso et al.   MOVEMENT DISORDERS

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

A novel design of a Phase III trial of isradipine in early Parkinson disease (STEADY-PD III)

(2017) Kevin M. Biglan et al.   Annals of Clinical and Translational Neurology

Calcium-activated SK channels control firing regularity by modulating sodium channel availability in midbrain dopamine neurons

(2017) Rajeshwari Iyer et al.   Scientific Reports

Endoplasmic reticulum and lysosomal Ca2+ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts

(2016) Bethan S. Kilpatrick et al.   CELL CALCIUM

Interactions between calcium channels and SK channels in midbrain dopamine neurons and their impact on pacemaker regularity: Contrasting roles of N- and L-type channels

(2016) Veronne de Vrind et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The relationship between glucocerebrosidase mutations and Parkinson disease

(2016) Anna Migdalska-Richards et al.   JOURNAL OF NEUROCHEMISTRY

Converging roles of ion channels, calcium, metabolic stress, and activity pattern ofSubstantia nigradopaminergic neurons in health and Parkinson's disease

(2016) Johanna Duda et al.   JOURNAL OF NEUROCHEMISTRY

Current and experimental treatments of Parkinson disease: A guide for neuroscientists

(2016) Wolfgang Oertel et al.   JOURNAL OF NEUROCHEMISTRY

Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons

(2016) F. Philippart et al.   JOURNAL OF NEUROSCIENCE

Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease

(2016) Efrat Lasser-Katz et al.   JOURNAL OF NEUROSCIENCE

The genetics of Parkinson's disease

(2015) Stephen Mullin et al.   BRITISH MEDICAL BULLETIN

Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons

(2015) Consiglia Pacelli et al.   CURRENT BIOLOGY

Gating of dopamine transmission by calcium and axonal N-, Q-, T- and L-type voltage-gated calcium channels differs between striatal domains

(2015) Katherine R. Brimblecombe et al.   JOURNAL OF PHYSIOLOGY-LONDON

Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice

(2015) Christina Poetschke et al.   Scientific Reports

Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons

(2014) Elena Dragicevic et al.   BRAIN

Aging Decreases L-Type Calcium Channel Currents and Pacemaker Firing Fidelity in Substantia Nigra Dopamine Neurons

(2014) S. Y. Branch et al.   JOURNAL OF NEUROSCIENCE

Mutant α-Synuclein Enhances Firing Frequencies in Dopamine Substantia Nigra Neurons by Oxidative Impairment of A-Type Potassium Channels

(2014) Mahalakshmi Subramaniam et al.   JOURNAL OF NEUROSCIENCE

Inhibition of A-Type Potassium Current by the Peptide Toxin SNX-482

(2014) T. Kimm et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase

(2014) Javier Sanchez-Padilla et al.   NATURE NEUROSCIENCE

The role of D2-autoreceptors in regulating dopamine neuron activity and transmission

(2014) C.P. Ford   NEUROSCIENCE

iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis

(2014) David C. Schöndorf et al.   Nature Communications

Parkinson’s disease: animal models and dopaminergic cell vulnerability

(2014) Javier Blesa et al.   Frontiers in Neuroanatomy

A Guide to Neurotoxic Animal Models of Parkinson's Disease

(2013) K. Tieu   Cold Spring Harbor Perspectives in Medicine

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's disease

(2012) Joshua A Goldberg et al.   NATURE NEUROSCIENCE

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

Compartmentalized signalling: Ca2+ compartments, microdomains and the many facets of Ca2+ signalling

(2009) Alex J. Laude et al.   FEBS Journal

Neuronal Calcium Sensor-1 (Ncs1p) Is Up-regulated by Calcineurin to Promote Ca2+Tolerance in Fission Yeast

(2009) Nobuko Hamasaki-Katagiri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Robust Pacemaking in Substantia Nigra Dopaminergic Neurons

(2009) J. N. Guzman et al.   JOURNAL OF NEUROSCIENCE

Unique Properties of Mesoprefrontal Neurons within a Dual Mesocorticolimbic Dopamine System

(2008) Stephan Lammel et al.   NEURON