Brain borders at the central stage of neuroimmunology

A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

(2022) Andrew C. Yang et al.   NATURE

Antibody Therapies in Autoimmune Encephalitis

(2022) I. Smets et al.   Neurotherapeutics

A single-cell atlas of the normal and malformed human brain vasculature

(2022) Ethan A. Winkler et al.   SCIENCE

Specification of CNS macrophage subsets occurs postnatally in defined niches

(2022) Takahiro Masuda et al.   NATURE

Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities

(2022) Abrar Choudhury et al.   NATURE GENETICS

New insights into the genetic etiology of Alzheimer’s disease and related dementias

(2022) Céline Bellenguez et al.   NATURE GENETICS

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

(2022) Jose A. Mazzitelli et al.   NATURE NEUROSCIENCE

Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis

(2022) Fadi E. Pulous et al.   NATURE NEUROSCIENCE

Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice

(2022) Matthew Simon et al.   Alzheimers Research & Therapy

Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited

(2022) Nanna MacAulay et al.   Fluids and Barriers of the CNS

Conserved meningeal lymphatic drainage circuits in mice and humans

(2022) Laurent Jacob et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct roles of the meningeal layers in CNS autoimmunity

(2022) Arianna Merlini et al.   NATURE NEUROSCIENCE

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

(2022) Antoine Drieu et al.   NATURE

Functional characterization of the dural sinuses as a neuroimmune interface

(2021) Justin Rustenhoven et al.   CELL

A cellular and spatial map of the choroid plexus across brain ventricles and ages

(2021) Neil Dani et al.   CELL

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

(2021) Sandro Da Mesquita et al.   NATURE

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

(2021) Ana Rita Pombo Antunes et al.   NATURE NEUROSCIENCE

A clinically applicable integrative molecular classification of meningiomas

(2021) Farshad Nassiri et al.   NATURE

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

(2021) Douglas P. Wightman et al.   NATURE GENETICS

Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges

(2021) David Schafflick et al.   NATURE NEUROSCIENCE

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

(2021) Andrea Cugurra et al.   SCIENCE

Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders

(2021) Simone Brioschi et al.   SCIENCE

Molecular trans-dural efflux to skull bone marrow in humans with cerebrospinal fluid disorders

(2021) Geir Ringstad et al.   BRAIN

Cerebrospinal fluid egress to human parasagittal dura and the impact of sleep deprivation

(2021) Per Kristian Eide et al.   BRAIN RESEARCH

Insular cortex neurons encode and retrieve specific immune responses

(2021) Tamar Koren et al.   CELL

The growth and expansion of meningeal lymphatic networks are affected in craniosynostosis

(2021) Phillip S. Ang et al.   DEVELOPMENT

Early developing B cells undergo negative selection by central nervous system-specific antigens in the meninges

(2021) Yan Wang et al.   IMMUNITY

B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity

(2021) Baihao Zhang et al.   NATURE

GABAergic neuronal IL-4R mediates T cell effect on memory

(2021) Jasmin Herz et al.   NEURON

A privileged brain

(2021) Justin Rustenhoven   SCIENCE

AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation

(2021) Faten A. Sayed et al.   Science Translational Medicine

Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients With Early Alzheimer Disease

(2021) Stephen Salloway et al.   JAMA Neurology

Magnetic resonance imaging of cerebrospinal fluid outflow after low-rate lateral ventricle infusion in mice

(2021) Yann Decker et al.   JCI Insight

Meningeal lymphatic vessels regulate brain tumor drainage and immunity

(2020) Xueting Hu et al.   CELL RESEARCH

VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

(2020) Eric Song et al.   NATURE

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

(2020) David Gate et al.   NATURE

Microglia mediate forgetting via complement-dependent synaptic elimination

(2020) Chao Wang et al.   SCIENCE

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

(2020) David Schafflick et al.   Nature Communications

Cerebrospinal fluid tracer efflux to parasagittal dura in humans

(2020) Geir Ringstad et al.   Nature Communications

Cxcl10+ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation

(2020) Amir Giladi et al.   NATURE IMMUNOLOGY

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

(2020) Yuanyuan Zhang et al.   Cellular & Molecular Immunology

Clinical Efficacy of Routinely Administered Belimumab on Proteinuria and Neuropsychiatric Lupus

(2020) Marlene Plüß et al.   Frontiers in Medicine

Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension

(2020) Monica M. Santisteban et al.   HYPERTENSION

Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons

(2020) Kalil Alves de Lima et al.   NATURE IMMUNOLOGY

Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface

(2020) Frederick B. Shipley et al.   NEURON

Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential

(2020) Siyi Huang et al.   CELL

Live Imaging of Intracranial Lymphatics in the Zebrafish

(2020) Daniel Castranova et al.   CIRCULATION RESEARCH

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells

(2019) Martin Hsu et al.   Nature Communications

Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein

(2019) Wenyan Zou et al.   Translational Neurodegeneration

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Dural lymphatics regulate clearance of extracellular tau from the CNS

(2019) Tirth K. Patel et al.   Molecular Neurodegeneration

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

(2019) Hannah Van Hove et al.   NATURE NEUROSCIENCE

Interleukin-1 reduces food intake and body weight in rat by acting in the arcuate hypothalamus

(2019) Léa Chaskiel et al.   BRAIN BEHAVIOR AND IMMUNITY

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

(2019) Ji Hoon Ahn et al.   NATURE

Single-cell analysis reveals T cell infiltration in old neurogenic niches

(2019) Ben W. Dulken et al.   NATURE

Panicle-Shaped Sympathetic Architecture in the Spleen Parenchyma Modulates Antibacterial Innate Immunity

(2019) Xiaofan Ding et al.   Cell Reports

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

(2019) Roeben Nocon Munji et al.   NATURE NEUROSCIENCE

Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory

(2019) Miguel Ribeiro et al.   Science Immunology

IL-17a promotes sociability in mouse models of neurodevelopmental disorders

(2019) Michael Douglas Reed et al.   NATURE

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury

(2018) Matthew V. Russo et al.   NATURE IMMUNOLOGY

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

(2018) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

The Choroid Plexus Functions as a Niche for T-Cell Stimulation Within the Central Nervous System

(2018) Itai Strominger et al.   Frontiers in Immunology

Leukaemia hijacks a neural mechanism to invade the central nervous system

(2018) Hisayuki Yao et al.   NATURE

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

(2018) Fanny Herisson et al.   NATURE NEUROSCIENCE

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

(2018) Antoine Louveau et al.   NATURE NEUROSCIENCE

TREM2 — a key player in microglial biology and Alzheimer disease

(2018) Tyler K. Ulland et al.   Nature Reviews Neurology

CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage

(2018) Jordi Pedragosa et al.   Acta Neuropathologica Communications

Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain

(2018) Qiaoli Ma et al.   ACTA NEUROPATHOLOGICA

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections

(2018) Ruiyao Cai et al.   NATURE NEUROSCIENCE

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

(2018) Samira Parhizkar et al.   NATURE NEUROSCIENCE

CNS infection and immune privilege

(2018) John V. Forrester et al.   NATURE REVIEWS NEUROSCIENCE

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Development and plasticity of meningeal lymphatic vessels

(2017) Salli Antila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

(2017) Aleksandra M. Wojtas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

(2017) Qiaoli Ma et al.   Nature Communications

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

(2017) Martina Absinta et al.   eLife

Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension

(2016) Giuseppe Faraco et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury

(2016) Sachin P. Gadani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

(2016) Christian Schläger et al.   NATURE

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

(2016) Anthony J. Filiano et al.   NATURE

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

(2016) G. B. Choi et al.   SCIENCE

Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier

(2015) Steffen E. Storck et al.   JOURNAL OF CLINICAL INVESTIGATION

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

(2015) Zhen Zhao et al.   NATURE NEUROSCIENCE

Revisiting the Mechanisms of CNS Immune Privilege

(2015) Antoine Louveau et al.   TRENDS IN IMMUNOLOGY

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Glioma

(2015) Michael Weller et al.   Nature Reviews Disease Primers

Failure of Perivascular Drainage of β-amyloid in Cerebral Amyloid Angiopathy

(2014) Cheryl A. Hawkes et al.   BRAIN PATHOLOGY

Synapse elimination and learning rules co-regulated by MHC class I H2-Db

(2014) Hanmi Lee et al.   NATURE

IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair

(2013) Gilad Kunis et al.   BRAIN

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

Transcranial amelioration of inflammation and cell death after brain injury

(2013) Theodore L. Roth et al.   NATURE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

We have got you ‘covered’: how the meninges control brain development

(2011) Julie A Siegenthaler et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Plasticity of the murine spleen T-cell cholinergic receptors and their role in in vitro differentiation of naïve CD4 T cells toward the Th1, Th2 and Th17 lineages

(2011) J Qian et al.   GENES AND IMMUNITY

Calcitonin Gene-Related Peptide Is an Important Regulator of Cutaneous Immunity: Effect on Dendritic Cell and T Cell Functions

(2011) N. Mikami et al.   JOURNAL OF IMMUNOLOGY

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Retinoic Acid from the Meninges Regulates Cortical Neuron Generation

(2009) Julie A. Siegenthaler et al.   CELL

Surgical excision of CNS-draining lymph nodes reduces relapse severity in chronic-relapsing experimental autoimmune encephalomyelitis

(2008) Marloes van Zwam et al.   JOURNAL OF PATHOLOGY

Getting specific: monoclonal antibodies in multiple sclerosis

(2008) Andreas Lutterotti et al.   LANCET NEUROLOGY