Failure of Perivascular Drainage of β-amyloid in Cerebral Amyloid Angiopathy

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models

(2013) Michal Arbel-Ornath et al.   ACTA NEUROPATHOLOGICA

Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain

(2013) Cheryl A. Hawkes et al.   AGING CELL

Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β

(2013) Simon J. Henderson et al.   BRAIN

 2 Integrin-Mediated Crawling on Endothelial ICAM-1 and ICAM-2 Is a Prerequisite for Transcellular Neutrophil Diapedesis across the Inflamed Blood-Brain Barrier

(2013) R. Gorina et al.   JOURNAL OF IMMUNOLOGY

Review: Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy

(2013) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Innate immunity receptor CD36 promotes cerebral amyloid angiopathy

(2013) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Real-Time In Vivo Imaging Reveals the Ability of Monocytes to Clear Vascular Amyloid Beta

(2013) Jean-Philippe Michaud et al.   Cell Reports

Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction

(2012) Jessica L. Teeling et al.   ACTA NEUROPATHOLOGICA

Heart Disease and Stroke Statistics—2013 Update

(2012) Alan S. Go et al.   CIRCULATION

Scavenger Receptor A Deficiency Accelerates Cerebrovascular Amyloidosis in an Animal Model

(2012) Veronica Lifshitz et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

(2012) Cheryl A. Hawkes et al.   PLoS One

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

(2011) Cheryl A. Hawkes et al.   ACTA NEUROPATHOLOGICA

Transcranial Doppler ultrasound blood flow velocity and pulsatility index as systemic indicators for Alzheimer’s disease

(2011) Alex E. Roher et al.   Alzheimers & Dementia

Real-Time Imaging of Perivascular Transport of Nanoparticles During Convection-Enhanced Delivery in the Rat Cortex

(2011) Conor P. Foley et al.   ANNALS OF BIOMEDICAL ENGINEERING

Fluid mechanics in the perivascular space

(2011) Peng Wang et al.   JOURNAL OF THEORETICAL BIOLOGY

Bapineuzumab

(2010) Geoffrey A Kerchner et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Review: Cerebral microvascular pathology in ageing and neurodegeneration

(2010) W. R. Brown et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain

(2010) F. Fernandez-Klett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model

(2010) K. Thanopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy

(2009) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Immunotherapy, Vascular Pathology, and Microhemorrhages in Transgenic Mice

(2009) Donna Wilcock et al.   CNS & Neurological Disorders-Drug Targets

CNS pericytes: Concepts, misconceptions, and a way out

(2009) Martin Krueger et al.   GLIA

Trafficking of Glucose, Lactate, and Amyloid-β from the Inferior Colliculus through Perivascular Routes

(2009) Kelly K Ball et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Macrophage-Mediated Degradation of  -Amyloid via an Apolipoprotein E Isoform-Dependent Mechanism

(2009) L. Zhao et al.   JOURNAL OF NEUROSCIENCE

Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic A  Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice

(2009) W. J. Meilandt et al.   JOURNAL OF NEUROSCIENCE

APOE  4 and bapineuzumab: Infusing pharmacogenomics into Alzheimer disease therapeutics

(2009) D. Kaufer et al.   NEUROLOGY

ApoE 4 reduces the expression of Aβ degrading enzyme IDE by activating the NMDA receptor in hippocampal neurons

(2009) Jing Du et al.   NEUROSCIENCE LETTERS

Lymphatic drainage of the brain and the pathophysiology of neurological disease

(2008) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain

(2008) D. Boche et al.   BRAIN

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer' Disease: The Role of the Immune System in Clearance of Aβ from the Brain

(2008) Delphine Boche et al.   BRAIN PATHOLOGY

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ-Degrading Enzymes in Alzheimer's Disease

(2008) James Scott Miners et al.   BRAIN PATHOLOGY

Structural Changes in Alzheimers Disease Brain Microvessels

(2008) Alexander Christov et al.   Current Alzheimer Research

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Interaction between β-amyloid protein and heparan sulfate proteoglycans from the cerebral capillary basement membrane in Alzheimer’s disease

(2008) Hajime Shimizu et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Cerebral Small Vessel Disease-Induced Apolipoprotein E Leakage Is Associated With Alzheimer Disease and the Accumulation of Amyloid β-Protein in Perivascular Astrocytes

(2008) Sabrina Utter et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Alzheimer’s disease — The ways of prevention

(2008) M. Kivipelto et al.   Journal of Nutrition Health & Aging

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

APOE genotype-specific differences in the innate immune response

(2007) Michael P. Vitek et al.   NEUROBIOLOGY OF AGING