Empagliflozin enhances neuroplasticity in rotenone-induced parkinsonism: Role of BDNF, CREB and Npas4

Empagliflozin Enhances Autophagy, Mitochondrial Biogenesis, and Antioxidant Defense and Ameliorates Renal Ischemia/Reperfusion in Nondiabetic Rats

(2022) Moein Ala et al.   Oxidative Medicine and Cellular Longevity

Empagliflozin attenuates neurodegeneration through antioxidant, anti-inflammatory, and modulation of α-synuclein and Parkin levels in rotenone-induced Parkinson’s disease in rats

(2022) Sanaa Ahmed et al.   SAUDI PHARMACEUTICAL JOURNAL

Empagliflozin Inhibits Hepatic Gluconeogenesis and Increases Glycogen Synthesis by AMPK/CREB/GSK3β Signalling Pathway

(2022) Xiaochen Yu et al.   Frontiers in Physiology

The Human Hippocampus in Parkinson’s Disease: An Integrative Stereological and Proteomic Study

(2021) Sandra Villar-Conde et al.   Journal of Parkinsons Disease

NRF2 Activation and Downstream Effects: Focus on Parkinson’s Disease and Brain Angiotensin

(2021) Juan A. Parga et al.   Antioxidants

Empagliflozin attenuates transient cerebral ischemia/reperfusion injury in hyperglycemic rats via repressing oxidative–inflammatory–apoptotic pathway

(2020) Entesar F. Amin et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

SGLT2 inhibitors: mechanisms of cardiovascular benefit beyond glycaemic control

(2020) Martin R. Cowie et al.   Nature Reviews Cardiology

Essential Functions of the Transcription Factor Npas4 in Neural Circuit Development, Plasticity, and Diseases

(2020) Jian Fu et al.   Frontiers in Neuroscience

Targeting oxidative stress, proinflammatory cytokines, apoptosis and toll like receptor 4 by empagliflozin to ameliorate bleomycin-induced lung fibrosis

(2019) Ahmed M. Kabel et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Serum concentration and clinical significance of brain-derived neurotrophic factor in patients with Parkinson’s disease or essential tremor

(2018) Yixian Huang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Modafinil alleviates levodopa-induced excessive nighttime sleepiness and restores monoaminergic systems in a nocturnal animal model of Parkinson's disease

(2018) Rina Ando et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Differential expression of the immediate early genes c-Fos , Arc , Egr-1 , and Npas4 during long-term memory formation in the context preexposure facilitation effect (CPFE)

(2018) Nicholas A. Heroux et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Targeting GSK3 signaling as a potential therapy of neurodegenerative diseases and aging

(2018) Przemysław Duda et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

NPAS4 recruits CCK basket cell synapses and enhances cannabinoid-sensitive inhibition in the mouse hippocampus

(2018) Andrea L Hartzell et al.   eLife

NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

(2018) Farzane Sivandzade et al.   Redox Biology

Neuroprotective effect of nebivolol against cisplatin-associated depressive-like behavior in rats

(2017) Noha F. Abdelkader et al.   JOURNAL OF NEUROCHEMISTRY

Cognitive impairment and BDNF serum levels

(2017) Joanna Siuda et al.   Neurologia i Neurochirurgia Polska

SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice

(2017) Liang Xu et al.   EBioMedicine

Carvedilol promotes mitochondrial biogenesis by regulating the PGC-1/TFAM pathway in human umbilical vein endothelial cells (HUVECs)

(2016) Kai Yao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons inpink1−/−zebrafish

(2016) Smijin Soman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration

(2016) Anne M.H. Woitecki et al.   JOURNAL OF NEUROSCIENCE

The Interaction of Mitochondrial Biogenesis and Fission/Fusion Mediated by PGC-1α Regulates Rotenone-Induced Dopaminergic Neurotoxicity

(2016) Kaige Peng et al.   MOLECULAR NEUROBIOLOGY

G protein-coupled receptor kinases as regulators of dopamine receptor functions

(2016) Eugenia V. Gurevich et al.   PHARMACOLOGICAL RESEARCH

Calcium/calmodulin-dependent protein kinase IV: A multifunctional enzyme and potential therapeutic target

(2016) Huma Naz et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

CREB expression mediates amyloid β-induced basal BDNF downregulation

(2015) Elyse Rosa et al.   NEUROBIOLOGY OF AGING

An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene–environment interactions

(2015) Michaela E. Johnson et al.   NEUROTOXICOLOGY

Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice

(2014) Bowen Lin et al.   Cardiovascular Diabetology

Direct and indirect pathways of basal ganglia: a critical reappraisal

(2014) Paolo Calabresi et al.   NATURE NEUROSCIENCE

Punctum on two different transcription factors regulated by PGC-1α: Nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2

(2013) Sara Baldelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Time course of dopamine neuron loss and glial response in the 6-OHDA striatal mouse model of Parkinson's disease

(2013) Simon R.W. Stott et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

(2013) Jing Qiu et al.   Nature Communications

Glycogen synthase kinase-3β activation mediates rotenone-induced cytotoxicity with the involvement of microtubule destabilization

(2012) Haruyuki Hongo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson’s disease models

(2012) Nian Xiong et al.   CRITICAL REVIEWS IN TOXICOLOGY

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

(2012) Meijuan Zhang et al.   PROGRESS IN NEUROBIOLOGY

Harnessing neuroplasticity for clinical applications

(2011) S. C. Cramer et al.   BRAIN

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Adenosine A2a receptor antagonists attenuate striatal adaptations following dopamine depletion

(2011) Jayms D. Peterson et al.   NEUROBIOLOGY OF DISEASE

Tyrosine hydroxylase and regulation of dopamine synthesis

(2010) S. Colette Daubner et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

PGC-1 , A Potential Therapeutic Target for Early Intervention in Parkinson's Disease

(2010) B. Zheng et al.   Science Translational Medicine

Mutual Dependence of Foxo3a and PGC-1α in the Induction of Oxidative Stress Genes

(2009) Yolanda Olmos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology

(2009) Robert E. Drolet et al.   NEUROBIOLOGY OF DISEASE

Transcription Factors in Long-Term Memory and Synaptic Plasticity

(2009) Cristina M. Alberini   PHYSIOLOGICAL REVIEWS

Involvment of Cytosolic and Mitochondrial GSK-3β in Mitochondrial Dysfunction and Neuronal Cell Death of MPTP/MPP+-Treated Neurons

(2009) Agnès Petit-Paitel et al.   PLoS One

Nuclear Calcium Signaling Controls Expression of a Large Gene Pool: Identification of a Gene Program for Acquired Neuroprotection Induced by Synaptic Activity

(2009) Sheng-Jia Zhang et al.   PLoS Genetics

BDNF activates CaMKIV and PKA in parallel to block MAG-mediated inhibition of neurite outgrowth

(2008) Timothy K. Spencer et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity

(2008) W. Shen et al.   SCIENCE